scholarly journals Associations between expression levels of nucleotide excision repair proteins in lymphoblastoid cells and risk of squamous cell carcinoma of the head and neck

2018 ◽  
Vol 57 (6) ◽  
pp. 784-793 ◽  
Author(s):  
Peng Han ◽  
Hongliang Liu ◽  
Qiong Shi ◽  
Zhensheng Liu ◽  
Jesse D. Troy ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Nucleotide Excision Repair ◽  
Squamous Cell ◽  
Excision Repair ◽  
Lymphoblastoid Cells ◽  
Expression Levels ◽  
Nucleotide Excision

scholarly journals XPD c.934G>A polymorphism of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation

Oncotarget ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 16190-16201 ◽  
Author(s):  
Leisa Lopes-Aguiar ◽  
Ericka Francislaine Dias Costa ◽  
Guilherme Augusto Silva Nogueira ◽  
Tathiane Regine Penna Lima ◽  
Marília Berlofa Visacri ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Nucleotide Excision Repair ◽  
Squamous Cell ◽  
Excision Repair ◽  
Neck Squamous Cell Carcinoma ◽  
Repair Pathway ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Pathway

scholarly journals Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck

Cancer ◽  
2002 ◽  
Vol 94 (2) ◽  
pp. 393-397 ◽  
Author(s):  
Lie Cheng ◽  
Erich M. Sturgis ◽  
Susan A. Eicher ◽  
Margaret R. Spitz ◽  
Qingyi Wei
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Nucleotide Excision Repair ◽  
Squamous Cell ◽  
Excision Repair ◽  
Nucleotide Excision ◽  
Repair Genes

XPD and ERCC1 polymorphisms of the nucleotide excision repair pathway in outcome of larynx squamous cell carcinoma patients.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e17523-e17523
Author(s):  
Carla Tyene Nakata ◽  
Ericka Francislaine Dias Costa ◽  
Bruno De Araujo Lima Franca ◽  
Leisa Lopes Aguiar ◽  
Fernanda Proa Ferreira ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nucleotide Excision Repair ◽  
Squamous Cell ◽  
Excision Repair ◽  
Repair Pathway ◽  
Nucleotide Excision ◽  
Nucleotide Excision Repair Pathway ◽  
Larynx Squamous Cell Carcinoma

Nucleotide Excision Repair Proteins and Risk of Head and Neck Squamous Cell Carcinomas in a Chinese Population

2020 ◽  
Author(s):  
Pengyu Ren ◽  
Xiaorong Niu ◽  
Ruimin Zhao ◽  
Zichen Chen ◽  
Hao Dai ◽  
...  
Keyword(s):  
Head And Neck ◽  
Nucleotide Excision Repair ◽  
Squamous Cell ◽  
Chinese Population ◽  
Excision Repair ◽  
Squamous Cell Carcinomas ◽  
Expression Levels ◽  
Increased Risk ◽  
Nucleotide Excision ◽  
Drinking Status

Abstract Background Nucleotide excision repair (NER) is pivotal in the development of smoking-related malignancies. We hypothesize that expression levels of NER proteins are associated with risk of the head and neck squamous cell carcinomas (HNSCCs) in a Chinese population. Methods To test this hypothesis, we conducted a case-control study of 337 HNSCC patients and 285 cancer-free controls by measuring the expression levels of nine core NER proteins in cultured peripheral lymphocytes. Results Compared with the controls, cases had statistically significantly lower expression levels of XPA (P=0.001). After dividing the subjects by controls’ medians of expression levels, we found an association between an increased risk of HNSCCs and low XPA expression levels [adjusted ORs and 95% CIs:1.42 and 1.03-1.96; Ptrend=0.031]. We identified a multiplicative interaction between smoking as well as drinking status and XPA expression levels (P = 0.005 and 0.044, respectively). Finally, the sensitivity of the expanded model with protein expression levels, in addition to demographic variables, on HNSCCs risk was significantly improved, especially among ever smokers and ever drinkers. Conclusions Reduced XPA expression levels were associated with an increased risk of HNSCCs in a Chinese population.

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