Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells

2016 ◽  
Vol 56 (2) ◽  
pp. 735-750 ◽  
Author(s):  
Lucía Flores-Peredo ◽  
Gabriela Rodríguez ◽  
Angel Zarain-Herzberg
Keyword(s):  
Colon Cancer ◽  
Endoplasmic Reticulum ◽  
Cell Differentiation ◽  
Cancer Cells ◽  
Calcium Atpase ◽  
Colon Cancer Cells ◽  
Endoplasmic Reticulum Calcium

scholarly journals Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment

Oncotarget ◽  
2016 ◽  
Vol 7 (27) ◽  
pp. 41432-41444 ◽  
Author(s):  
Aditi Banerjee ◽  
Hafiz Ahmed ◽  
Peixin Yang ◽  
Steven J. Czinn ◽  
Thomas G. Blanchard
Keyword(s):  
Colon Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Colon Cancer Cells

scholarly journals PRMT1 inhibition induces differentiation of colon cancer cells

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alexander Plotnikov ◽  
Noga Kozer ◽  
Galit Cohen ◽  
Silvia Carvalho ◽  
Shirly Duberstein ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Differentiation ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Human Colon ◽  
Colon Cancer Cell ◽  
Colon Cancer Cells ◽  
Differentiation Therapy ◽  
Human Colon Cancer ◽  
Ht 29

AbstractDifferentiation therapy has been recently revisited as a prospective approach in cancer therapy by targeting the aberrant growth, and repairing the differentiation and cell death programs of cancer cells. However, differentiation therapy of solid tumors is a challenging issue and progress in this field is limited. We performed High Throughput Screening (HTS) using a novel dual multiplex assay to discover compounds, which induce differentiation of human colon cancer cells. Here we show that the protein arginine methyl transferase (PRMT) type 1 inhibitor, MS023, is a potent inducer of colon cancer cell differentiation with a large therapeutic window. Differentiation changes in the highly aggressive human colon cancer cell line (HT-29) were proved by proteomic and genomic approaches. Growth of HT-29 xenograft in nude mice was significantly delayed upon MS023 treatment and immunohistochemistry of tumor indicated differentiation changes. These findings may lead to development of clinically effective anti-cancer drugs based on the mechanism of cancer cell differentiation.

Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells

2017 ◽  
Vol 56 (6) ◽  
pp. 1603-1619 ◽  
Author(s):  
Pinar Obakan-Yerlikaya ◽  
Elif Damla Arisan ◽  
Ajda Coker-Gurkan ◽  
Kaan Adacan ◽  
Utku Ozbey ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Fine Tuning ◽  
Colon Cancer Cells ◽  
Induced Apoptosis
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