Genome-wide analysis of DNA copy number alterations in early and advanced gastric cancers

2016 ◽  
Vol 56 (2) ◽  
pp. 527-537 ◽  
Author(s):  
Noriyuki Arakawa ◽  
Tamotsu Sugai ◽  
Wataru Habano ◽  
Makoto Eizuka ◽  
Ryo Sugimoto ◽  
...  
Keyword(s):  
Copy Number ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Genome Wide Analysis ◽  
Gastric Cancers ◽  
Genome Wide ◽  
Dna Copy Number Alterations

Genome‐wide analysis of DNA copy number alterations and gene expression in gastric cancer

2008 ◽  
Vol 216 (4) ◽  
pp. 471-482 ◽  
Author(s):  
Y Tsukamoto ◽  
T Uchida ◽  
S Karnan ◽  
T Noguchi ◽  
LT Nguyen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Copy Number ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Dna Copy Number Alterations

Genome-Wide High-Resolution Screening in Dupuytren's Disease Reveals Common Regions of DNA Copy Number Alterations

2010 ◽  
Vol 35 (7) ◽  
pp. 1172-1183.e7 ◽  
Author(s):  
Barbara B. Shih ◽  
May Tassabehji ◽  
James S. Watson ◽  
Angus D. McGrouther ◽  
Ardeshir Bayat
Keyword(s):  
High Resolution ◽  
Copy Number ◽  
Dupuytren’S Disease ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Dupuytren's Disease ◽  
Genome Wide ◽  
Dna Copy Number Alterations

scholarly journals Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival

2020 ◽  
Vol 4 (2) ◽  
pp. 026106
Author(s):  
Sri Priya Ponnapalli ◽  
Matthew W. Bradley ◽  
Karen Devine ◽  
Jay Bowen ◽  
Sara E. Coppens ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Copy Number ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Genome Wide ◽  
Dna Copy Number Alterations

Sex-dependent differences in DNA copy number alterations in hepatocellular carcinoma

2012 ◽  
Vol 32 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Bing-ji WEN ◽  
Wen-ming CONG ◽  
Ai-zhong WANG ◽  
Song-qin HE ◽  
Hong-mei JIANG ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Copy Number ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Dna Copy Number Alterations

scholarly journals From Benign Inflammatory Dermatosis to Cutaneous Lymphoma. DNA Copy Number Imbalances in Mycosis Fungoides versus Large Plaque Parapsoriasis

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 502
Author(s):  
Georgiana Gug ◽  
Caius Solovan
Keyword(s):  
Mycosis Fungoides ◽  
Copy Number ◽  
Snp Array ◽  
Chromosome 1 ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Large Plaque ◽  
Inflammatory Dermatosis ◽  
Fresh Frozen ◽  
Dna Copy Number Alterations

Background and Objectives: Mycosis fungoides (MF) and large plaque parapsoriasis (LPP) evolution provide intriguing data and are the cause of numerous debates. The diagnosis of MF and LPP is associated with confusion and imprecise definition. Copy number alterations (CNAs) may play an essential role in the genesis of cancer out of genes expression dysregulation. Objectives: Due to the heterogeneity of MF and LPP and the scarcity of the cases, there are an exceedingly small number of studies that have identified molecular changes in these pathologies. We aim to identify and compare DNA copy number alterations and gene expression changes between MF and LPP to highlight the similarities and the differences between these pathologies. Materials and Methods: The patients were prospectively selected from University Clinic of Dermatology and Venereology Timișoara, Romania. From fresh frozen skin biopsies, we extracted DNA using single nucleotide polymorphism (SNP) data. The use of SNP array for copy number profiling is a promising approach for genome-wide analysis. Results: After reviewing each group, we observed that the histograms generated for chromosome 1–22 were remarkably similar and had a lot of CNAs in common, but also significant differences were seen. Conclusions: This study took a step forward in finding out the differences and similarities between MF and LPP, for a more specific and implicitly correct approach of the case. The similarity between these two pathologies in terms of CNAs is striking, emphasizing once again the difficulty of approaching and differentiating them.

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