scholarly journals Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma

2015 ◽  
Vol 55 (8) ◽  
pp. 1243-1250
Author(s):  
Jennifer D. Cohen ◽  
Matthew Labenski ◽  
Nicholas J. Mastrandrea ◽  
Ryan D. Canatsey ◽  
Terrence J. Monks ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Renal Cell ◽  
Post Translational Modifications

scholarly journals ERK Crosstalks with 4EBP1 to Activate Cyclin D1 Translation during Quinol-Thioether–Induced Tuberous Sclerosis Renal Cell Carcinoma

2011 ◽  
Vol 124 (1) ◽  
pp. 75-87 ◽  
Author(s):  
Jennifer D. Cohen ◽  
Jaime M. C. Gard ◽  
Raymond B. Nagle ◽  
Justin D. Dietrich ◽  
Terrence J. Monks ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Tuberous Sclerosis ◽  
Renal Cell

scholarly journals Molecular Characterization and Putative Pathogenic Pathways of Tuberous Sclerosis Complex–Associated Renal Cell Carcinoma

2018 ◽  
Vol 11 (4) ◽  
pp. 962-970 ◽  
Author(s):  
Jeong Hwan Park ◽  
Cheol Lee ◽  
Mee Soo Chang ◽  
Kwangsoo Kim ◽  
Seongmin Choi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Molecular Characterization ◽  
Tuberous Sclerosis Complex ◽  
Renal Cell

Renal Angiomyolipoma: Report of three cases with Regional Lymph Node Involvement and/or with Renal Cell Carcinoma

1995 ◽  
Vol 81 (6) ◽  
pp. 469-474 ◽  
Author(s):  
György Csanaky ◽  
Zoltán Szereday ◽  
Tamás Magyarlaki ◽  
Gábor Méhes ◽  
Tamás Herbert ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Malignant Transformation ◽  
Renal Cell ◽  
Dna Ploidy ◽  
Lymph Node Involvement ◽  
Node Involvement

Aims and background Angiomyolipomas (AMLs) are benign hamartoid tumors which frequently occur in tuberous sclerosis (TS). They may be manifest at different organ sites such as kidneys, lymph nodes, liver and lung and may be associated with renal cell carcinoma (RCC). The nature of multiple organ involvement in AML (metastasis versus multicentric synchronous tumors), the malignant transformation and the relation of AML to RCC have not been sufficiently clarified. Study design Three cases of renal AMLs in patients with tuberous sclerosis associated with lymphangioleiomyomatosis of the paraaortic lymph nodes and/or with RCC are reported. The concise clinical history of the patients as well as the findings of histology, immunohistochemistry and quantitative DNA analysis are presented. Results The multicentric form of AML and coincidence of renal AML and RCC were observed in 2 patients. AML and RCC were found within the same focus in one of the cases. RCCs were either aneuploid or “near diploid”, whereas one of the multicentric AMLs showed a discordant DNA ploidy pattern, namely aneuploidy in the kidney and diploidy in the lymph nodes. Conclusions The presented cases (all of them underwent periaortic lymphadenectomy) suggest that lymph node involvement in renal AML may be more frequent than expected (1-2% of all AMLs) on the basis of the few reported cases. The discordant DNA ploidy (renal versus lymph node lesions) observed in one of the cases with multicentric AML implies synchronous tumor growth at different sites rather than metastatic disease. The intimate coexistance of RCC and AML (RCC revealed by immunohistochemistry within a larger mass of renal AML) may indicate that malignant transformation of an AML should only be accepted, if such a coincidence is unequivocally excluded.

Sirolimus therapy for fibromatosis and multifocal renal cell carcinoma in a child with tuberous sclerosis complex

2010 ◽  
pp. n/a-n/a ◽  
Author(s):  
Joseph G. Pressey ◽  
Jordan M. Wright ◽  
James I. Geller ◽  
David B. Joseph ◽  
Christine S. Pressey ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Renal Cell

scholarly journals Bilateral Renal Cell Carcinoma in a Patient with Tuberous Sclerosis

1996 ◽  
Vol 3 (2) ◽  
pp. 150-151 ◽  
Author(s):  
Teruyoshi Aoyarna ◽  
Keita Fujikawa ◽  
Koji Yoshimura ◽  
Miharu Sasaki ◽  
Tadahiro Ltoh
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Renal Cell ◽  
Bilateral Renal Cell Carcinoma

scholarly journals A Case of Tuberous Sclerosis Complex with Lymphangioleiomyomatosis and Renal Cell Carcinoma

2020 ◽  
Vol Volume 13 ◽  
pp. 12421-12426
Author(s):  
Yun Wu ◽  
Hongru Li ◽  
Xiaoli Yu ◽  
Ming Lin ◽  
Yusheng Chen
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Renal Cell

scholarly journals Renal cell carcinoma with leiomyomatous stroma in tuberous sclerosis complex: a distinct entity

2020 ◽  
Author(s):  
Marjorie Gournay ◽  
Frédéric Dugay ◽  
Marc-Antoine Belaud-Rotureau ◽  
Benoit Peyronnet ◽  
Romain Mathieu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Renal Cell ◽  
Distinct Entity

scholarly journals A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma

2005 ◽  
Vol 14 (13) ◽  
pp. 1839-1850 ◽  
Author(s):  
Catherine Wilson ◽  
Shelley Idziaszczyk ◽  
Lee Parry ◽  
Carol Guy ◽  
David F.R. Griffiths ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Mouse Model ◽  
Cell Carcinoma ◽  
Tuberous Sclerosis ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Natal Mortality
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