Essential role of Her3 in two signaling transduction patterns: Her2/Her3 and MET/Her3 in proliferation of human gastric cancer

2014 ◽  
Vol 54 (12) ◽  
pp. 1700-1709 ◽  
Author(s):  
Chen Yun ◽  
Li Gang ◽  
Gu Rongmin ◽  
Wen Xu ◽  
Ming Xuezhi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Essential Role ◽  
Human Gastric Cancer ◽  
Signaling Transduction

6650 Myc-dependent regulation and prgonostic role of Myc stabilizing protein, CIP2A, in human gastric cancer

2009 ◽  
Vol 7 (2) ◽  
pp. 403 ◽  
Author(s):  
A. Khanna ◽  
C. Böckelman ◽  
J. Westermarck ◽  
A. Ristimäki
Keyword(s):  
Gastric Cancer ◽  
Human Gastric Cancer

scholarly journals BAG3 contributes to HGF-mediated cell proliferation, migration, and invasion via the Egr1 pathway in gastric cancer

2018 ◽  
Vol 105 (1) ◽  
pp. 63-75
Author(s):  
Jae Chang Lee ◽  
Sung Ae Koh ◽  
Kyung Hee Lee ◽  
Jae-Ryong Kim
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cell Invasion ◽  
Molecular Mechanisms ◽  
Migration And Invasion ◽  
Human Gastric Cancer ◽  
Protein Levels ◽  
Dependent Pathway

Introduction: Bcl2-associated athanogene 3 (BAG3) is elevated in several types of cancers. However, the role of BAG3 in progression of gastric cancer is unknown. Therefore, the present study aims to find out the role of BAG3 in hepatocyte growth factor (HGF)–mediated tumor progression and the molecular mechanisms by which HGF regulates BAG3 expression. Methods: BAG3 mRNA and protein were measured using reverse transcription polymerase chain reaction and Western blot in the 2 human gastric cancer cell lines, NUGC3 and MKN28, treated with or without HGF. The effects of BAG3 knockdown on cell proliferation, cell invasion, and apoptosis were analyzed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the in vitro 2-chamber invasion assay, and flow cytometry in BAG3 short hairpin RNA (shRNA)–transfected cells and control cells. The signaling pathways involved in BAG3 that are regulated by HGF were analyzed. The chromatin immunoprecipitation assay was used to determine binding of Egr1 to the BAG3 promoter. Results: BAG3 mRNA and protein levels were increased following treatment with HGF. HGF-mediated BAG3 upregulation increased cell proliferation and cell invasion; however, it decreased apoptosis. HGF-mediated BAG3 upregulation is regulated by an ERK and Egr1-dependent pathway. BAG3 may have an important role in HGF-mediated cell proliferation and metastasis in gastric cancer through an ERK and Egr1-dependent pathway. Conclusion: This pathway may provide novel therapeutic targets and provide information for further identification of other targets of therapeutic significance in gastric cancer.

scholarly journals Role of PCDH10 and its hypermethylation in human gastric cancer

2012 ◽  
Vol 1823 (2) ◽  
pp. 298-305 ◽  
Author(s):  
Zesong Li ◽  
James C.S. Chim ◽  
Mo Yang ◽  
Jieyu Ye ◽  
Benjamin C.Y. Wong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Human Gastric Cancer

scholarly journals Essential role of gastric gland mucin in preventing gastric cancer in mice

2012 ◽  
Vol 122 (3) ◽  
pp. 923-934 ◽  
Author(s):  
Fumitoshi Karasawa ◽  
Akira Shiota ◽  
Yukinobu Goso ◽  
Motohiro Kobayashi ◽  
Yoshiko Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Essential Role ◽  
Gastric Gland

Novel regulator role of CIL-102 in the epigenetic modification of TNFR1/TRAIL to induce cell apoptosis in human gastric cancer

2021 ◽  
Vol 147 ◽  
pp. 111856
Author(s):  
Chih-Chuan Teng ◽  
Shui-Yi Tung ◽  
Ko-Chao Lee ◽  
Kam-Fai Lee ◽  
Wen-Shih Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Apoptosis ◽  
Epigenetic Modification ◽  
Human Gastric Cancer ◽  
Induce Cell Apoptosis

scholarly journals The essential role of TNIK gene amplification in gastric cancer growth

Oncogenesis ◽  
2014 ◽  
Vol 3 (2) ◽  
pp. e89-e89 ◽  
Author(s):  
D-H Yu ◽  
X Zhang ◽  
H Wang ◽  
L Zhang ◽  
H Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Amplification ◽  
Essential Role ◽  
Cancer Growth
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