Establishment and characterization of metastatic gastric cancer cell lines from murine gastric adenocarcinoma lacking Smad4, p53, and E-cadherin

2014 ◽  
Vol 54 (11) ◽  
pp. 1521-1527 ◽  
Author(s):  
Jun Won Park ◽  
Dong Min Park ◽  
Beom K. Choi ◽  
Byoung S. Kwon ◽  
Je Kyung Seong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Adenocarcinoma ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Metastatic Gastric Cancer ◽  
Cancer Cell Lines ◽  
Gastric Cancer Cell Lines ◽  
E Cadherin

scholarly journals Cyclooxygenase-2 Mediated Regulation of E-Cadherin Occurs in Conventional But Not Early-Onset Gastric Cancer Cell Lines

2009 ◽  
Vol 31 (6) ◽  
pp. 475-485
Author(s):  
R. Sitarz ◽  
R. J. Leguit ◽  
W. W. J. de Leng ◽  
F. H. M. Morsink ◽  
W. P. Polkowski ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Early Onset ◽  
Gastric Cancer Cell ◽  
Cancer Cell Lines ◽  
Gastric Cancers ◽  
Gastric Cancer Cell Lines ◽  
Cox 2 ◽  
E Cadherin

Background: COX-2 and E-cadherin, involved in invasion and metastasis, are molecules critical for gastric carcinogenesis. A relationship between them is documented in non-small cell lung and prostate cancer. We present novel evidence of a relationship between COX-2 and E-cadherin expression in gastric cancer.Methods: Using qPCR and Western blots analysis on celecoxib and PGE2 treated and untreated gastric cancer cell lines derived from tumours of the intestinal type (MKN45, MKN28, AGS3, MKN7) and immunohistochemistry of 178 gastric cancers on tissue microarrays (TMA), we examined the COX-2/E-cadherin relationship.Results: Down-regulation of COX-2 by celecoxib led to up-regulation of E-cadherin mRNA and protein levels in conventional gastric cancer cell lines, whereas expression was down regulated in the early-onset gastric cancer (EOGC) cell line. Immunohistochemistry on TMAs of 178 gastric cancers showed no correlation between COX-2 and E-cadherin expression in the conventional or early gastric cancer groups.Conclusions: The results suggest that COX-2 has an impact on transcriptional regulation of E-cadherin in gastric cancer and our findings further highlight the intriguing nature of EOGCs which appear to have a molecular phenotype distinct from conventional gastric cancer. In addition, our findings also suggest that reduction of COX-2 using nonsteroidal anti-inflammatory drugs in gastric cancer chemoprevention may only be relevant for older patients.

scholarly journals Functional and transcriptomic characterization of cisplatin-resistant AGS and MKN-28 gastric cancer cell lines

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0228331
Author(s):  
Barbara Mora-Lagos ◽  
Irene Cartas-Espinel ◽  
Ismael Riquelme ◽  
Alyssa C. Parker ◽  
Stephen R. Piccolo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Lines ◽  
Gastric Cancer Cell Lines

scholarly journals Establishment and conventional cytogenetic characterization of three gastric cancer cell lines

2009 ◽  
Vol 195 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Mariana Ferreira Leal ◽  
José Luiz Martins do Nascimento ◽  
Carla Elvira Araújo da Silva ◽  
Maria Fernanda Vita Lamarão ◽  
Danielle Queiroz Calcagno ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Lines ◽  
Gastric Cancer Cell Lines ◽  
Cytogenetic Characterization

scholarly journals Genotypic and Phenotypic Characterization of Side Population of Gastric Cancer Cell Lines

2011 ◽  
Vol 178 (4) ◽  
pp. 1792-1804 ◽  
Author(s):  
Rosa Schmuck ◽  
Viktoria Warneke ◽  
Hans-Michael Behrens ◽  
Eva Simon ◽  
Wilko Weichert ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Side Population ◽  
Cancer Cell Lines ◽  
Phenotypic Characterization ◽  
Gastric Cancer Cell Lines

scholarly journals Characterization of sphere-forming cells with stem-like properties from the gastric cancer cell lines MKN45 and SGC7901

2014 ◽  
Vol 10 (6) ◽  
pp. 2937-2941 ◽  
Author(s):  
XUMING WANG ◽  
FENG ZOU ◽  
HAO DENG ◽  
ZHENGQI FU ◽  
YAN LI ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Lines ◽  
Gastric Cancer Cell Lines

Characterization of four new gastric cancer cell lines

1993 ◽  
Vol 63 (1) ◽  
pp. 335-343 ◽  
Author(s):  
H. Peter Vollmers ◽  
Konrad Stulle ◽  
Jobst Dämmrich ◽  
Martin Pfaff ◽  
Th. Papadopoulos ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Lines ◽  
Gastric Cancer Cell Lines

scholarly journals Expression of microsomal prostaglandin E synthase-1 in intestinal type gastric adenocarcinoma and in gastric cancer cell lines

2003 ◽  
Vol 107 (4) ◽  
pp. 551-556 ◽  
Author(s):  
Bastiaan P. van Rees ◽  
Anna Sivula ◽  
Staffan Thorén ◽  
Hiroshi Yokozaki ◽  
Per-Johan Jakobsson ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Adenocarcinoma ◽  
Cell Lines ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Lines ◽  
Intestinal Type ◽  
Prostaglandin E ◽  
Prostaglandin E Synthase ◽  
Gastric Cancer Cell Lines
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