scholarly journals Nucleolin binds specifically to an AP-1 DNA sequence and represses AP1-dependent transactivation of the matrix metalloproteinase-13 gene

2007 ◽  
Vol 47 (1) ◽  
pp. 34-46 ◽  
Author(s):  
Shaija Samuel ◽  
Jean-Claude Twizere ◽  
Katherine K. Beifuss ◽  
Lori R. Bernstein
Keyword(s):  
Matrix Metalloproteinase ◽  
Dna Sequence ◽  
Matrix Metalloproteinase 13 ◽  
The Matrix

scholarly journals Matrix metalloproteinase 13 is transcriptionally modulated in the spinal cords of salamanders during spinal cord regeneration.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Spinal Cord ◽  
Matrix Metalloproteinase ◽  
Transcriptional Response ◽  
Spinal Cord Regeneration ◽  
Significant Differential Expression ◽  
Matrix Metalloproteinase 13 ◽  
Complete Transection ◽  
Ability To Regenerate ◽  
The Matrix ◽  
The Central Nervous System

In nature, there are extraordinary creatures that have the ability to regenerate the spinal cord following a severing injury; these include the axolotl salamander (1, 2, 3, 4). To being to attempt to understand the mechanisms by which this transpires, we studied the transcriptional response to spinal cord trauma in a creature capable of spinal cord regeneration using microarray data (5, 6) from a severing injury model in the axolotl. We observed significant differential expression of the matrix metalloproteinase 13, MMP13, during regeneration of the spinal cord following complete transection. MMP13 is likely one actor in a complex multi-step process by which the central nervous system regenerates itself.

Overexpression of Runx2 directed by the matrix metalloproteinase-13 promoter containing the AP-1 and Runx/RD/Cbfa sites alters bone remodeling in vivo

2006 ◽  
Vol 99 (2) ◽  
pp. 545-557 ◽  
Author(s):  
Nagarajan Selvamurugan ◽  
Stephen C. Jefcoat ◽  
Sukyee Kwok ◽  
Rodney Kowalewski ◽  
Joseph A. Tamasi ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Bone Remodeling ◽  
Matrix Metalloproteinase 13 ◽  
The Matrix

scholarly journals Role of Gene Polymorphisms of Matrix Metalloproteinases-2, -3 and -13 in the Development of Coronary Artery Atherosclerosis in Patients with Primary Polyosteoarthrosis

2020 ◽  
Vol 10 (2) ◽  
pp. 155-160
Author(s):  
O. O. Portyannikova ◽  
E. N. Romanova ◽  
A. V. Govorin ◽  
S. M. Tsvinger
Keyword(s):  
Matrix Metalloproteinase ◽  
Odds Ratio ◽  
Coronary Atherosclerosis ◽  
Coronary Vessels ◽  
Atherosclerotic Lesions ◽  
Matrix Metalloproteinase 13 ◽  
Coronary Artery Atherosclerosis ◽  
Heterozygous Variant ◽  
The Matrix

The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis.Materials and methods. The polymorphisms of the Thе pоlymоrphisms оf thе matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) and their connection with development of atherosclerosis in patients with osteoarthritis were determined.Results. In the process of studying the polymorphism (rs2252070 T/C) of the MMP — 13 gene, it was revealed that the carriage of the homozygous T allele of the MMP-13 gene polymorphism is 1,8 times higher in the group of patients without verified coronary atherosclerosis in comparison with a group of patients with verified coronary atherosclerosis. This fact shows that this genotypic variant is protective in relation to the development of atherosclerotic lesions of the coronary vessels. The heterozygous variant of the T/C genotype was more common in the group of patients with verified coronay atherosclerosis — 59%. The calculation of the odds ratio shows that the possibility of developing coronary atherosclerosis in patients with this genotype is 2,7 times higher than in patients with a homozygous grnotypic variant.Conclusion. It is shown that the heterozygous variant of rs2252070 T/C matrix metalloproteinase 13 increases the chance of developing coronary atherosclerosis in patients with osteoarthritis.

scholarly journals Role of Gene Polymorphisms of Matrix Metalloproteinases-2, -3 and -13 in the Development of Coronary Artery Atherosclerosis in Patients with Primary Polyosteoarthrosis

2020 ◽  
Vol 10 (2) ◽  
pp. 155-160
Author(s):  
O. O. Portyannikova ◽  
E. N. Romanova ◽  
A. V. Govorin ◽  
S. M. Tsvinger
Keyword(s):  
Matrix Metalloproteinase ◽  
Odds Ratio ◽  
Coronary Atherosclerosis ◽  
Coronary Vessels ◽  
Atherosclerotic Lesions ◽  
Matrix Metalloproteinase 13 ◽  
Coronary Artery Atherosclerosis ◽  
Heterozygous Variant ◽  
The Matrix

The aim of the research. To assess the influence of polymorphisms of the matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) on the development of coronary atherosclerosis in patients with primary osteoarthritis.Materials and methods. The polymorphisms of the Thе pоlymоrphisms оf thе matrix metalloproteinase genes — 2 (rs2285053), — 3 (rs3025058), and — 13 (rs2252070) and their connection with development of atherosclerosis in patients with osteoarthritis were determined.Results. In the process of studying the polymorphism (rs2252070 T/C) of the MMP — 13 gene, it was revealed that the carriage of the homozygous T allele of the MMP-13 gene polymorphism is 1,8 times higher in the group of patients without verified coronary atherosclerosis in comparison with a group of patients with verified coronary atherosclerosis. This fact shows that this genotypic variant is protective in relation to the development of atherosclerotic lesions of the coronary vessels. The heterozygous variant of the T/C genotype was more common in the group of patients with verified coronay atherosclerosis — 59%. The calculation of the odds ratio shows that the possibility of developing coronary atherosclerosis in patients with this genotype is 2,7 times higher than in patients with a homozygous grnotypic variant.Conclusion. It is shown that the heterozygous variant of rs2252070 T/C matrix metalloproteinase 13 increases the chance of developing coronary atherosclerosis in patients with osteoarthritis.

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