The high-risk benign tumor: Evidence from the two-stage skin cancer model and relevance for human cancer

2007 ◽  
Vol 46 (8) ◽  
pp. 605-610 ◽  
Author(s):  
Adam Glick ◽  
Andrew Ryscavage ◽  
Rolando Perez-Lorenzo ◽  
Henry Hennings ◽  
Stuart Yuspa ◽  
...  
Keyword(s):  
High Risk ◽  
Skin Cancer ◽  
Benign Tumor ◽  
Human Cancer ◽  
Cancer Model ◽  
Two Stage

scholarly journals Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model

Oncogene ◽  
2002 ◽  
Vol 21 (24) ◽  
pp. 3836-3846 ◽  
Author(s):  
Yunfent Zhao ◽  
Terry D Oberley ◽  
Luksana Chaiswing ◽  
Shu-mei Lin ◽  
Charles J Epstein ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Skin Cancer ◽  
Manganese Superoxide Dismutase ◽  
Tumor Promoter ◽  
Cell Turnover ◽  
Cancer Model ◽  
Manganese Superoxide

High-risk HPV-positive human cancer cell lines show different sensitivity to cisplatin-induced apoptosis correlated with the p21Waf1/Cip1 level

1996 ◽  
Vol 108 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Kohsei Funaoka ◽  
Masanobu Shindoh ◽  
Toshiharu Yamashita ◽  
Kei Fujinaga ◽  
Akira Amemiya ◽  
...  
Keyword(s):  
High Risk ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Induced Apoptosis ◽  
High Risk Hpv

scholarly journals Prognostic Gene Signature for Squamous Cell Carcinoma with a Higher Risk for Treatment Failure and Accelerated MEK-ERK Pathway Activity

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5182
Author(s):  
Bohai Feng ◽  
Kai Wang ◽  
Esther Herpel ◽  
Michaela Plath ◽  
Wilko Weichert ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cox Regression ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
The Cancer Genome Atlas ◽  
Mek Inhibitors ◽  
Prognostic Gene

Squamous cell carcinoma (SCC) is the most prevalent histological type of human cancer, including head and neck squamous cell carcinoma (HNSCC). However, reliable prognostic gene signatures for SCC and underlying genetic and/or epigenetic principles are still unclear. We identified 37 prognostic candidate genes by best cutoff computation based on survival in a pan-SCC cohort (n = 1334) of The Cancer Genome Atlas (TCGA), whose expression stratified not only the pan-SCC cohort but also independent HNSCC validation cohorts into three distinct prognostic subgroups. The most relevant prognostic genes were prioritized by a Least Absolute Shrinkage and Selection Operator Cox regression model and were used to identify subgroups with high or low risks for unfavorable survival. An integrative analysis of multi-omics data identified FN1, SEMA3A, CDH2, FBN1, COL5A1, and ADAM12 as key nodes in a regulatory network related to the prognostic phenotype. An in-silico drug screen predicted two MEK inhibitors (Trametinib and Selumetinib) as effective compounds for high-risk SCC based on the Cancer Cell Line Encyclopedia, which is supported by a higher p-MEK1/2 immunohistochemical staining of high-risk HNSCC. In conclusion, our data identified a molecular classifier for high-risk HNSCC as well as other SCC patients, who might benefit from treatment with MEK inhibitors.

scholarly journals Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma

2020 ◽  
Vol 12 (562) ◽  
pp. eaba4434
Author(s):  
Karin Hansson ◽  
Katarzyna Radke ◽  
Kristina Aaltonen ◽  
Jani Saarela ◽  
Adriana Mañas ◽  
...  
Keyword(s):  
High Risk ◽  
Human Cancer ◽  
Neuroblastoma Cell ◽  
Human Tumor ◽  
Loss Of Function ◽  
Human Cancer Cell Lines ◽  
Dismal Prognosis ◽  
Tumor Types ◽  
Genome Scale

Neuroblastoma is a childhood malignancy with often dismal prognosis; relapse is common despite intense treatment. Here, we used human tumor organoids representing multiple MYCN-amplified high-risk neuroblastomas to perform a high-throughput drug screen with approved or emerging oncology drugs. Tumor-selective effects were calculated using drug sensitivity scores. Several drugs with previously unreported anti-neuroblastoma effects were identified by stringent selection criteria. ARRY-520, an inhibitor of kinesin spindle protein (KSP), was among those causing reduced viability. High expression of the KSP-encoding gene KIF11 was associated with poor outcome in neuroblastoma. Genome-scale loss-of-function screens in hundreds of human cancer cell lines across 22 tumor types revealed that KIF11 is particularly important for neuroblastoma cell viability. KSP inhibition in neuroblastoma patient-derived xenograft (PDX) cells resulted in the formation of abnormal monoastral spindles, mitotic arrest, up-regulation of mitosis-associated genes, and apoptosis. In vivo, KSP inhibition caused regression of MYCN-amplified neuroblastoma PDX tumors. Furthermore, treatment of mice harboring orthotopic neuroblastoma PDX tumors resulted in increased survival. Our results suggested that KSP inhibition could be a promising treatment strategy in children with high-risk neuroblastoma.

scholarly journals Accuracy of mobile digital teledermoscopy for skin self-examinations in adults at high risk of skin cancer: an open-label, randomised controlled trial

2020 ◽  
Vol 2 (3) ◽  
pp. e129-e137 ◽  
Author(s):  
Monika Janda ◽  
Caitlin Horsham ◽  
Dimitrios Vagenas ◽  
Lois J Loescher ◽  
Nicole Gillespie ◽  
...  
Keyword(s):  
High Risk ◽  
Randomised Controlled Trial ◽  
Skin Cancer ◽  
Controlled Trial ◽  
Open Label ◽  
Randomised Controlled
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