The feasibility of monitoring NF-κB associated cytokines: TNF-α, IL-1α, IL-6, and IL-8 in whole saliva for the malignant transformation of oral lichen planus

2005 ◽  
Vol 44 (2) ◽  
pp. 77-82 ◽  
Author(s):  
Nelson L. Rhodus ◽  
Bin Cheng ◽  
Sandra Myers ◽  
Lindsay Miller ◽  
Vu Ho ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Tnf Α ◽  
Whole Saliva ◽  
Oral Lichen

scholarly journals Salivary levels of tumor necrosis factor-α in oral lichen planus

2004 ◽  
Vol 13 (2) ◽  
pp. 131-133 ◽  
Author(s):  
Sonja Pezelj-Ribaric ◽  
Ivana Brekalo Prso ◽  
Maja Abram ◽  
Irena Glazar ◽  
Gordana Brumini ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Lichen Planus ◽  
Tumor Necrosis ◽  
Oral Lichen Planus ◽  
Necrosis Factor Alpha ◽  
Clinical Forms ◽  
Tnf Α ◽  
Whole Saliva ◽  
Oral Lichen ◽  
Necrosis Factor

OBJECTIVE: Oral lichen planus (OLP) is chronic inflammatory disease of the oral mucosa, presenting in various clinical forms. The etiology of OLP is still unknown but mounting evidence points to the immunologic basis of this disorder.Aim: Our study was undertaken to quantify the salivary levels of pro-inflammatory tumor necrosis factor-alpha (TNF-α) in the reticular and the erosive/atrophic forms of OLP, compared with age-matched healthy control volunteers.Subjects and methods: Whole saliva from 40 patients with active lesions of OLP, as well as from 20 healthy persons, was investigated for the presence of TNF-α by enzyme immunoassay.Results: Salivary TNF-α levels were significantlly increased in patients with OLP in comparison with healthy subjects. The presence of TNF-α showed positive correlation to clinical forms of OLP, being significantly higher in the erosive/atrophic type than in the reticular type of disease.Conclusion: Saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity. In patients with OLP, TNF-α levels in saliva are elevated, correlating with the severity of illness. Salivary TNF-α analysis may be a useful diagnostic tool and a potential prognostic marker in OLP.

scholarly journals A Rare Case of Malignant Transformation of Oral Lichen Planus of the Mandible

2016 ◽  
Vol 4 (12) ◽  
pp. e1070
Author(s):  
Joanne Soo ◽  
George Kokosis ◽  
Michael Ogilvie ◽  
Xiaoyin “Sara Jiang ◽  
David B. Powers ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Rare Case ◽  
Oral Lichen Planus ◽  
Oral Lichen

scholarly journals Malignant transformation of oral lichen planus in lingual location: report of a case

2004 ◽  
Vol 40 (1) ◽  
pp. 1-4 ◽  
Author(s):  
José Manuel Gándara-Rey ◽  
Márcio Diniz Freitas ◽  
Pilar Gándara Vila ◽  
Andrés Blanco Carrión ◽  
José Manuel Suárez Peñaranda ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

Malignant transformation of ulcerative oral lichen planus

2021 ◽  
Vol 20 (3) ◽  
pp. 134
Author(s):  
V.A. Molochkov ◽  
Yu.V. Molochkova ◽  
A.N. Khlebnikova ◽  
A.A. Rylkova
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Oral Lichen

Narrow-band imaging: a useful tool for early recognition of oral lichen planus malignant transformation?

2019 ◽  
Vol 29 (5) ◽  
pp. 500-506 ◽  
Author(s):  
Emanuele Cozzani ◽  
Roberto Russo ◽  
Francesco Mazzola ◽  
Sabrina Garofolo ◽  
Marco Camerino ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Early Recognition ◽  
Oral Lichen

scholarly journals Is Topical Application of Hyaluronic Acid in Oral Lichen Planus Effective? A Randomized Controlled Crossover Study

2020 ◽  
Vol 10 (22) ◽  
pp. 7988
Author(s):  
Corinna Bruckmann ◽  
Rudolf Seemann ◽  
Klemens Rappersberger ◽  
Xiaohui Rausch-Fan ◽  
Hady Haririan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Severity ◽  
Clinical Parameters ◽  
Whole Saliva ◽  
Before And After ◽  
Crossover Phase ◽  
Lost To Follow Up ◽  
Oral Lichen

Hyaluronic acid (HA) has anti-inflammatory and anti-edematous effects and, thus, could be promising in the treatment of oral lichen planus (OLP). The aim of the study was to evaluate the effects of topical hyaluronic acid, compared to placebo, on salivary levels of calprotectin, interleukin-6 (IL-6), and bacteria, as well as clinical and subjective parameters. Fourteen patients with confirmed OLP were included. After random selection, patients started with either 0.2% hyaluronic acid or a placebo gel for 6 weeks. Following a wash-out period, the groups changed the application. Whole saliva, clinical parameters, and questionnaires were evaluated before and after the intervention, as well as after the crossover phase. Salivary calprotectin, IL-6, and inflammation-related bacteria were determined by ELISA and PCR, respectively. There were no significant differences in clinical or subjective outcome parameters, salivary levels of IL-6, calprotectin, or bacteria after the application of hyaluronic acid, compared to placebo. However, only nine patients completed the study, as five out of seven patients starting with placebo were lost to follow-up. Significant effects of HA on inflammatory mediators and clinical parameters in OLP patients could not be proven, although a trend in clinical severity improvement could be observed.

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