scholarly journals Evaluating antibacterial and anticancer activity of crude extracts of bacterial endophytes from Crinum macowanii Baker bulbs

2019 ◽  
Vol 8 (12) ◽  
Author(s):  
Tendani E. Sebola ◽  
Nkemdinma C. Uche‐Okereafor ◽  
Kudzanai I. Tapfuma ◽  
Lukhanyo Mekuto ◽  
Ezekiel Green ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Bacterial Endophytes ◽  
Crude Extracts ◽  
Antibacterial And Anticancer Activity

Researches on the Synthesis and Biological Activity of 1,2,4-tiadizoles-3,5-disubstituted using Ditiazolium Salts as Precursors

2008 ◽  
Vol 59 (1) ◽  
pp. 101-105
Author(s):  
Irina Zarafu ◽  
Lucia Veronica Ivan ◽  
Iuliana Harasim
Keyword(s):  
Biological Activity ◽  
Comparative Study ◽  
Anticancer Activity ◽  
Reaction Process ◽  
Physical Analysis ◽  
Ultrasound Exposure ◽  
Medium Activity ◽  
Antibacterial And Anticancer Activity

3,5-disubstituted-1,2,4-tiadiazoles with substituted-styril and heterocycle-vinyl were obtained by extending the method which implies the use of 3,5-disubstituted-1,2,4-ditiazolium salts as precursors [1-4]. A comparative study of the reaction process in the case of perchlorates, diacide phosphates, tribromides and 3,5-distyrile-dithiazolium triiodides, taken as etalon, was perfomed. Good yields were obtained when using perchlorates, phosphates and triiodides. The reaction was made by heating the reaction mixture and by ultrasound exposure. The structure of the compounds was confirmed by chemical and physical analysis and the data obtained were identical to those of 3,5-disubstituted-1,2,4-tiadiazoles obtained by another methods [5,6]. The biological (antibacterial and anticancer) activity of the synthesized compounds was tested and the results indicated a medium activity.

Synthesis, Spectral Characterization, Antibacterial and Anticancer Activity of some Titanium Complexes

2018 ◽  
Vol 18 (5) ◽  
pp. 739-746 ◽  
Author(s):  
Raj Kaushal ◽  
Nitesh Kumar ◽  
Archana Thakur ◽  
Kiran Nehra ◽  
Pamita Awasthi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Spectral Characterization ◽  
Mechanistic Study ◽  
Titanium Complexes ◽  
G0 Phase ◽  
Antibacterial And Anticancer Activity ◽  
Dose Dependent

Abstract: Background: After the discovery of cisplatin, first non platinum anticancer drugs having excellent efficacy were budotitane and TiCl2(cp)2 but action mechanism is not clear. Therefore, we hereby reporting synthesis and biological activities novel titanium complexes to explore their mode of action. Objectives: Synthesis, spectral characterization, antibacterial and anticancer activity of some titanium complexes. Antibacterial studies on various bacterial strains and anticancer studies on HeLa, C6, CHO cancerous cell lines have been performed. Further, the cell death mechanistic study was done on CHO cell lines. Method: Titanium complexes with and without labile groups have been synthesized by reacting of TiCl4 with nitrogen containing ligands viz. 1,2-diaminocyclohexane, 1,10-Phenanthroline, adamantylamine, 2,2'-bipyridine, 4,4'-dimethyl-2,2'-bipyridine in predetermined molar ratios. Antibacterial and anticancer studies were performed by agar well diffusion method and MTT assay respectively. Cell cycle analysis is done by using flow cytometry. Results: Complex 2 i.e TiCl2(Phen)2 showed better activity than other complexes as an antibacterial as well as anticancer agent. Phase contrast imaging indicates that observed morphological changes of cells was dose dependent. Cell death mechanistic study have shown the increase in sub G0 phase population as well as formation of blebbing and fragmentation of chromatin material which is an indicative measure of apoptosis. Conclusion: Complex 2 proved to be more effective bactericide and cytotoxic agent. Cell cycle analysis showed cell arrest in G0 phase. Apoptosis percentage was found to increase in a dose dependent manner. So, prepared titanium complexes can be put to use as an important chemotherapeutic agents.

A novel herbometallic nanodrug has the potential for antibacterial and anticancer activity through oxidative damage

Nanomedicine ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. 1173-1189 ◽  
Author(s):  
Bhuban Ruidas ◽  
Sutapa Som Chaudhury ◽  
Kunal Pal ◽  
Prashanta Kumar Sarkar ◽  
Chitrangada Das Mukhopadhyay
Keyword(s):  
Oxidative Damage ◽  
Anticancer Activity ◽  
Antibacterial And Anticancer Activity

Origanum vulgare mediated biosynthesis of silver nanoparticles for its antibacterial and anticancer activity

2013 ◽  
Vol 108 ◽  
pp. 80-84 ◽  
Author(s):  
Renu Sankar ◽  
Arunachalam Karthik ◽  
Annamalai Prabu ◽  
Selvaraju Karthik ◽  
Kanchi Subramanian Shivashangari ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Anticancer Activity ◽  
Origanum Vulgare ◽  
Antibacterial And Anticancer Activity
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