scholarly journals Identification and characterization of a carnitine transporter in Acinetobacter baumannii

2018 ◽  
Vol 8 (6) ◽  
Author(s):  
Jennifer Breisch ◽  
Izabela Waclawska ◽  
Beate Averhoff
Keyword(s):  
Acinetobacter Baumannii ◽  
Carnitine Transporter ◽  
Identification And Characterization

scholarly journals First Identification and Characterization of an AdeABC-Like Efflux Pump inAcinetobacterGenomospecies 13TU

2011 ◽  
Vol 55 (3) ◽  
pp. 1285-1286 ◽  
Author(s):  
Ignasi Roca ◽  
Paula Espinal ◽  
Sara Martí ◽  
Jordi Vila
Keyword(s):  
Multidrug Resistance ◽  
Acinetobacter Baumannii ◽  
Clinical Isolate ◽  
Nosocomial Infections ◽  
Efflux Pump ◽  
Hospital Setting ◽  
Multidrug Resistant ◽  
Identification Techniques ◽  
Identification And Characterization

ABSTRACTNon-Acinetobacter baumanniispp. are emerging among clinicalAcinetobacterisolates causing nosocomial infections, and some (such as genomospecies 13TU) appear to be multidrug resistant. The prevalence of non-Acinetobacter baumanniispp. in the hospital setting is likely understated due to poor identification techniques. We report the first identification of an AdeABC-type efflux pump in anAcinetobactergenomospecies 13TU clinical isolate, its contribution to multidrug resistance, and the coexistence of three Ade-type efflux pumps in this strain.

Identification and characterization of an indigo-producing oxygenase involved in indole 3-acetic acid utilization by Acinetobacter baumannii

2012 ◽  
Vol 101 (4) ◽  
pp. 881-890 ◽  
Author(s):  
Guang-Huey Lin ◽  
Hao-Ping Chen ◽  
Jui-Hsin Huang ◽  
Tze-Tze Liu ◽  
Tze-Kang Lin ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Acinetobacter Baumannii ◽  
Identification And Characterization ◽  
Indole 3 Acetic Acid

scholarly journals Identification and Characterization of a Glycosyltransferase Involved in Acinetobacter baumannii Lipopolysaccharide Core Biosynthesis

2010 ◽  
Vol 78 (5) ◽  
pp. 2017-2023 ◽  
Author(s):  
Nicole R. Luke ◽  
Shauna L. Sauberan ◽  
Thomas A. Russo ◽  
Janet M. Beanan ◽  
Ruth Olson ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Acinetobacter Baumannii ◽  
Lipid A ◽  
Genetic Approach ◽  
Core Oligosaccharide ◽  
Normal Human ◽  
Identification And Characterization

ABSTRACT Although Acinetobacter baumannii has emerged as a significant cause of nosocomial infections worldwide, there have been few investigations describing the factors important for A. baumannii persistence and pathogenesis. This paper describes the first reported identification of a glycosyltransferase, LpsB, involved in lipopolysaccharide (LPS) biosynthesis in A. baumannii. Mutational, structural, and complementation analyses indicated that LpsB is a core oligosaccharide glycosyl transferase. Using a genetic approach, lpsB was compared with the lpsB homologues of several A. baumannii strains. These analyses indicated that LpsB is highly conserved among A. baumannii isolates. Furthermore, we developed a monoclonal antibody, monoclonal antibody 13C11, which reacts to an LPS core epitope expressed by approximately one-third of the A. baumannii clinical isolates evaluated to date. Previous studies describing the heterogeneity of A. baumannii LPS were limited primarily to structural analyses; therefore, studies evaluating the correlation between these surface glycolipids and pathogenesis were warranted. Our data from an evaluation of LpsB mutant 307::TN17, which expresses a deeply truncated LPS glycoform consisting of only two 3-deoxy-d-manno-octulosonic acid residues and lipid A, suggest that A. baumannii LPS is important for resistance to normal human serum and confers a competitive advantage for survival in vivo. These results have important implications for the role of LPS in A. baumannii infections.

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