scholarly journals Spoligotype‐based population structure of Mycobacterium tuberculosis in the Jimma Zone, southwest Ethiopia

2018 ◽  
Vol 8 (6) ◽  
Author(s):  
Gemeda Abebe ◽  
Ketema Abdissa ◽  
Kedir Abdella ◽  
Mulualem Tadesse ◽  
Adane Worku ◽  
...  
2016 ◽  
pp. 91-110
Author(s):  
Tefera Belachew ◽  
David Lindstrom ◽  
Craig Hadley ◽  
Abebe Gebremariam ◽  
Wondwosen Kasahun ◽  
...  

2011 ◽  
Vol 10 (1) ◽  
Author(s):  
Tefera Belachew ◽  
Craig Hadley ◽  
David Lindstrom ◽  
Abebe Gebremariam ◽  
Carl Lachat ◽  
...  

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Anna Engström ◽  
Uladzimir Antonenka ◽  
Abdylat Kadyrov ◽  
Gulmira Kalmambetova ◽  
Katharina Kranzer ◽  
...  

Abstract Background Drug-resistant tuberculosis (TB) is a major public health concern threathing the success of TB control efforts, and this is particularily problematic in Central Asia. Here, we present the first analysis of the population structure of Mycobacterium tuberculosis complex isolates in the Central Asian republics Uzbekistan, Tajikistan, and Kyrgyzstan. Methods The study set consisted of 607 isolates with 235 from Uzbekistan, 206 from Tajikistan, and 166 from Kyrgyzstan. 24-loci MIRU-VNTR (Mycobacterial Interspersed Repetitive Units - Variable Number of Tandem Repeats) typing and spoligotyping were combined for genotyping. In addition, phenotypic drug suceptibility was performed. Results The population structure mainly comprises strains of the Beijing lineage (411/607). 349 of the 411 Beijing isolates formed clusters, compared to only 33 of the 196 isolates from other clades. Beijing 94–32 (n = 145) and 100–32 (n = 70) formed the largest clusters. Beijing isolates were more frequently multidrug-resistant, pre-extensively resistant (pre-XDR)- or XDR-TB than other genotypes. Conclusions Beijing clusters 94–32 and 100–32 are the dominant MTB genotypes in Central Asia. The relative size of 100–32 compared to previous studies in Kazakhstan and its unequal geographic distribution support the hypothesis of its more recent emergence in Central Asia. The data also demonstrate that clonal spread of resistant TB strains, particularly of the Beijing lineage, is a root of the so far uncontroled MDR-TB epidemic in Central Asia.


2020 ◽  
Vol Volume 12 ◽  
pp. 45-55
Author(s):  
Muluneh Getachew Garedew ◽  
Shimeles Ololo Sinkie ◽  
Dejene Melese Handalo ◽  
Waju Beyene Salgedo ◽  
Kidus Yitebarek Kehali ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93848 ◽  
Author(s):  
Teresa Realpe ◽  
Nidia Correa ◽  
Juan Carlos Rozo ◽  
Beatriz Elena Ferro ◽  
Verónica Gomez ◽  
...  

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