Relevance of the Polymeric Prodrug and Its Drug Loading Efficiency: Comparison between Computer Simulation and Experiment

2019 ◽  
Vol 28 (5) ◽  
pp. 1900026 ◽  
Author(s):  
Xueli Luo ◽  
Shenchun Wang ◽  
Sishi Xu ◽  
Meidong Lang
Keyword(s):  
Computer Simulation ◽  
Drug Loading ◽  
Loading Efficiency ◽  
Polymeric Prodrug ◽  
Simulation And Experiment ◽  
Drug Loading Efficiency ◽  
Efficiency Comparison

Improving drug loading efficiency and delivery performance of micro- and nanoparticle preparations through optimising formulation variables

2013 ◽  
Vol 10 (10/11) ◽  
pp. 996 ◽  
Author(s):  
Chiao Hsi Chiang ◽  
Hossein Hosseinkhani ◽  
Wen Sheng Cheng ◽  
g Wei Chen ◽  
Chun Hsiang Wang ◽  
...  
Keyword(s):  
Drug Loading ◽  
Delivery Performance ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Formulation Variables

Novel dual VES phospholipid self-assembled liposomes with an extremely high drug loading efficiency

2017 ◽  
Vol 156 ◽  
pp. 29-37 ◽  
Author(s):  
Yongpeng Hou ◽  
Chen Yao ◽  
Longbing Ling ◽  
Yawei Du ◽  
Ruiyu He ◽  
...  
Keyword(s):  
Drug Loading ◽  
High Drug ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Self Assembled ◽  
High Drug Loading

Synthesize and survey the drug loading efficiency of the porous nano silica modified by gelatin

2019 ◽  
Vol 10 (3) ◽  
pp. 035017 ◽  
Author(s):  
Uyen Vy Vo ◽  
Van Cuong Nguyen ◽  
Xuan Vu Duong Vo ◽  
Minh Khang Tan Vo ◽  
Hoang Ai Le Pham ◽  
...  
Keyword(s):  
Drug Loading ◽  
Nano Silica ◽  
Loading Efficiency ◽  
Drug Loading Efficiency

scholarly journals PEG-PCL Nanocapsules Containing Curcumin: Validation of HPLC Method for Analyzing Drug-loading Efficiency, Stability Testing and Cytotoxicity on NIH-3T3 Cell Line

2020 ◽  
Vol 63 ◽  
Author(s):  
Loanda Aparecida Cabral Rudnik ◽  
Amanda Martinez Lyra ◽  
Fernanda Malaquias Barboza ◽  
Traudi Klein ◽  
Carla Cristine Kanunfre ◽  
...  
Keyword(s):  
Cell Line ◽  
Drug Loading ◽  
Hplc Method ◽  
Stability Testing ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Nih 3T3

Determination of drug loading efficiency of nano capsules formed by the O/W emulsification of block copolymer

2020 ◽  
Vol 26 ◽  
pp. 720-723
Author(s):  
Christina Vincent ◽  
Kiran M.D ◽  
Jitha S. Jayan ◽  
Appukuttan Saritha
Keyword(s):  
Block Copolymer ◽  
Drug Loading ◽  
Loading Efficiency ◽  
Drug Loading Efficiency

Preparation and Properties of PLA Microspheres Containing ENRO by an S/O/W Emulsion Technique

2011 ◽  
Vol 335-336 ◽  
pp. 1439-1442 ◽  
Author(s):  
Yu Yan Zhou ◽  
Gui Yu Li ◽  
Hong Xia Wang ◽  
Lei Tao ◽  
Jian Ping Liang
Keyword(s):  
High Performance ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Poly Lactic Acid ◽  
Modified Technique ◽  
Loading Efficiency ◽  
Oil In Water ◽  
Drug Loading Efficiency

In the present paper, monodisperse poly(lactic acid) (PLA) microspheres (MS) containing the enrofloxacin (ENRO), were manufactured by using a modified solid in oil in water (S/O/W) emulsion solvent evaporation method. In order to prepare PLA microspheres with a higher drug loading efficiency by this modified technique, the test of stability and productivity of the primary emulsion was preliminary examined by change species or concentration of the oil-soluble surfactant and the ratio of water and organic solvent. Firstly, enrofloxacin polylactic acid microspheres (ENRO-PLA-MS) were producted, then the morphology and particle size distribution were estimated by scanning electron microscopy (SEM), its encapsulation efficiency and drug loading efficiency were assessed by High performance liquid chromatography (HPLC). In vivo conditions were simulated by an stable release buffer to obtain a detailed release and polymer degradation profile. Consequently, the ENRO-PLA-MS had a denser structure with a smooth, pore-free surface, the preparation of microspheres was simple, the prepared microspheres had excellent controlled drug release characteristics in vitro.

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