Effect of Poly(ethylene glycol) on the Ultrastructure and Physicochemical Properties of the Poly(3-hydroxybutyrate)

2017 ◽  
Vol 375 (1) ◽  
pp. 1600189 ◽  
Author(s):  
Vsevolod A. Zhuikov ◽  
A. P. Bonartsev ◽  
I. I. Zharkova ◽  
G. S. Bykova ◽  
N. Y. Taraskin ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Physicochemical Properties ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Insulin/poly(ethylene glycol)-block-poly(l-lysine) Complexes: Physicochemical Properties and Protein Encapsulation

2015 ◽  
Vol 119 (22) ◽  
pp. 6813-6819 ◽  
Author(s):  
Natassa Pippa ◽  
Radostina Kalinova ◽  
Ivaylo Dimitrov ◽  
Stergios Pispas ◽  
Costas Demetzos
Keyword(s):  
Ethylene Glycol ◽  
Physicochemical Properties ◽  
Protein Encapsulation ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals A simple approach to hybrid inorganic–organic step-growth hydrogels with scalable control of physicochemical properties and biodegradability

2015 ◽  
Vol 6 (12) ◽  
pp. 2183-2187 ◽  
Author(s):  
F. Alves ◽  
I. Nischang
Keyword(s):  
Ethylene Glycol ◽  
Physicochemical Properties ◽  
Polyhedral Oligomeric Silsesquioxane ◽  
Simple Approach ◽  
Poly Ethylene Glycol ◽  
Step Growth ◽  
Poly Ethylene ◽  
Oligomeric Silsesquioxane

We prepared new and scalable, hybrid inorganic–organic step-growth hydrogels with polyhedral oligomeric silsesquioxane (POSS) network knot construction elements and hydrolytically degradable poly(ethylene glycol) (PEG) di-ester macromonomers by in situ radical-mediated thiol–ene photopolymerization.

scholarly journals Physicochemical, Pharmacokinetic, and Toxicity Evaluation of Methoxy Poly(ethylene glycol)-b-Poly(d,l-Lactide) Polymeric Micelles Encapsulating Alpinumisoflavone Extracted from Unripe Cudrania tricuspidata Fruit

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 366 ◽  
Author(s):  
Min Jeong Jo ◽  
Yang Hee Jo ◽  
Yu Jin Lee ◽  
Chun-Woong Park ◽  
Jin-Seok Kim ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Physicochemical Properties ◽  
Polymeric Micelles ◽  
Pharmacokinetic Studies ◽  
Severe Toxicity ◽  
Poly Ethylene Glycol ◽  
Cudrania Tricuspidata ◽  
Poly Ethylene

Alpinumisoflavone, a major compound in unripe Cudrania tricuspidata fruit is reported to exhibit numerous beneficial pharmacological activities, such as osteoprotective, antibacterial, estrogenic, anti-metastatic, atheroprotective, antioxidant, and anticancer effects. Despite its medicinal value, alpinumisoflavone is poorly soluble in water, which makes it difficult to formulate and administer intravenously (i.v.). To overcome these limitations, we used methoxy poly(ethylene glycol)-b-poly(d,l-lactide) (mPEG-b-PLA) polymeric micelles to solubilize alpinumisoflavone and increase its bioavailability, and evaluated their toxicity in vivo. Alpinumisoflavone-loaded polymeric micelles were prepared using thin-film hydration method, and their physicochemical properties were characterized for drug release, particle size, drug-loading (DL, %), and encapsulation efficiency (EE, %). The in vitro drug release profile was determined and the release rate of alpinumisoflavone from mPEG-b-PLA micelles was slower than that from drug solution, and sustained. Pharmacokinetic studies showed decreased total clearance and volume of distribution of alpinumisoflavone, whereas area under the curve (AUC) and bioavailability were significantly increased by incorporation in mPEG-b-PLA micelles. In vivo toxicity assay revealed that alpinumisoflavone-loaded mPEG-b-PLA micelles had no severe toxicity. In conclusion, we prepared an intravenous (i.v.) injectable alpinumisoflavone formulation, which was solubilized using mPEG-b-PLA micelles, and determined their physicochemical properties, pharmacokinetics, and toxicity profiles.

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