In Vitro and In Vivo Evaluation of a Multifunctional Hyaluronic acid Based Hydrogel System for Local Application on the Retina

2011 ◽  
Vol 309-310 (1) ◽  
pp. 229-235 ◽  
Author(s):  
A. T. Neffe ◽  
K. A. Kobuch ◽  
M. Maier ◽  
N. Feucht ◽  
C. P. Lohmann ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Local Application ◽  
In Vivo Evaluation ◽  
Hydrogel System

CD44 targeting biocompatible and biodegradable hyaluronic acid cross-linked zein nanogels for curcumin delivery to cancer cells: In vitro and in vivo evaluation

2018 ◽  
Vol 280 ◽  
pp. 20-30 ◽  
Author(s):  
Hae-Yong Seok ◽  
N. Sanoj Rejinold ◽  
Kamali Manickavasagam Lekshmi ◽  
Kondareddy Cherukula ◽  
In-Kyu Park ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
In Vivo Evaluation ◽  
Cd44 Targeting

scholarly journals Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers

2019 ◽  
Vol 8 (9) ◽  
pp. 1486 ◽  
Author(s):  
Barbara De Angelis ◽  
Margarida Fernandes Lopes Morais D’Autilio ◽  
Fabrizio Orlandi ◽  
Giampiero Pepe ◽  
Simone Garcovich ◽  
...  
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
Platelet Rich Plasma ◽  
Combined Treatment ◽  
Skin Grafting ◽  
Control Group ◽  
In Vivo Evaluation ◽  
Chronic Ulcers

Chronic ulcers are characterized by loss of substance without a normal tendency towards spontaneous healing. The Wound Bed Preparation Guideline advises that after diagnosis, the expert should correct the biological state of the ulcer micro-environment based on TIME principles (Tissue, Infection, Moisture balance, Epidermal). There are many ways to treat such ulcers, for example through use of advanced dressings, negative pressure, surgical toilets, dermal substitutes, autologous skin grafting, and free or local flaps. In vitro and in vivo pre-clinical models hold widely acknowledged potential yet complex limitations. Tissue bioengineering could be an ideal approach to foster innovative strategies in wound healing. Our observational study reports on an in vitro and in vivo evaluation of a bio-functionalized scaffold composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) used in 182 patients affected by chronic ulcers (diabetic and vascular), comparing the results with a control group of 182 patients treated with traditional dressings (HA alone). After 30 days the patients who had undergone the combined treatment (PRP + HA), showed 96.8% ± 1.5% re-epithelialization, as compared to 78.4% ± 4.4% in the control group (HA only). Within 80 days, they had 98.4% ± 1.3% re-epithelialization as compared to 87.8% ± 4.1% in the control group (HA only; p < 0.05). No local recurrence was observed during the follow-up period. PRP + HA treatment showed stronger regenerative potential in terms of epidermal proliferation and dermal renewal compared with HA alone.

Hyaluronic acid-quercetin conjugate micelles: Synthesis, characterization, in vitro and in vivo evaluation

2014 ◽  
Vol 123 ◽  
pp. 778-786 ◽  
Author(s):  
Xin Pang ◽  
Zhen Lu ◽  
Hongliang Du ◽  
Xiaoye Yang ◽  
Guangxi Zhai
Keyword(s):  
Hyaluronic Acid ◽  
In Vivo Evaluation

scholarly journals Wound healing activity of curcumin conjugated to hyaluronic acid: in vitro and in vivo evaluation

2017 ◽  
Vol 46 (5) ◽  
pp. 1009-1017 ◽  
Author(s):  
Mrinalini Sharma ◽  
Khageswar Sahu ◽  
Surya Prakash Singh ◽  
Beena Jain
Keyword(s):  
Wound Healing ◽  
Hyaluronic Acid ◽  
In Vivo Evaluation ◽  
Wound Healing Activity

Hyaluronic acid based micelle for articular delivery of triamcinolone, preparation, in vitro and in vivo evaluation

2015 ◽  
Vol 489 (1-2) ◽  
pp. 218-225 ◽  
Author(s):  
Ebrahim Saadat ◽  
Naeeme Shakor ◽  
Mehdi Gholami ◽  
Farid A. Dorkoosh
Keyword(s):  
Hyaluronic Acid ◽  
In Vivo Evaluation

Synthesis and optimization of a novel polymeric micelle based on hyaluronic acid and phospholipids for delivery of paclitaxel, in vitro and in-vivo evaluation

2014 ◽  
Vol 475 (1-2) ◽  
pp. 163-173 ◽  
Author(s):  
Ebrahim Saadat ◽  
Mohsen Amini ◽  
Mohammad Reza Khoshayand ◽  
Rassoul Dinarvand ◽  
Farid A. Dorkoosh
Keyword(s):  
Hyaluronic Acid ◽  
Polymeric Micelle ◽  
In Vivo Evaluation

Budesonide nanocrystal-loaded hyaluronic acid microparticles for inhalation: In vitro and in vivo evaluation

2018 ◽  
Vol 181 ◽  
pp. 1143-1152 ◽  
Author(s):  
Tingting Liu ◽  
Meihua Han ◽  
Fang Tian ◽  
Dongmei Cun ◽  
Jukka Rantanen ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
In Vivo Evaluation

Co-delivery of timolol and hyaluronic acid from semi-circular ring-implanted contact lenses for the treatment of glaucoma: in vitro and in vivo evaluation

2018 ◽  
Vol 6 (6) ◽  
pp. 1580-1591 ◽  
Author(s):  
Ankita R. Desai ◽  
Furqan A. Maulvi ◽  
Mihir M. Pandya ◽  
Ketan M. Ranch ◽  
Bhavin A. Vyas ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Contact Lenses ◽  
Controlled Drug Release ◽  
Circular Ring ◽  
In Vivo Evaluation

Controlled drug release from semi-circular drug-loaded ring-implanted contact lenses.

scholarly journals Correction: In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups

RSC Advances ◽  
2017 ◽  
Vol 7 (48) ◽  
pp. 30049-30050
Author(s):  
Zhihong Zhu ◽  
Dongyang Li ◽  
Yuenan Li ◽  
Xinggang Yang ◽  
Weisan Pan
Keyword(s):  
Hyaluronic Acid ◽  
Targeted Delivery ◽  
Amphiphilic Copolymers ◽  
In Vivo Evaluation

Correction for ‘In vitro–in vivo evaluation of hyaluronic acid-based amphiphilic copolymers for tumour targeted delivery: the role of hydrophobic groups’ by Zhihong Zhu et al., RSC Adv., 2017, 7, 23942–23953.

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