Mass spectrometry-based proteomics: The road to lung cancer biomarker discovery

2012 ◽  
Vol 32 (2) ◽  
pp. 129-142 ◽  
Author(s):  
Paola Indovina ◽  
Eleonora Marcelli ◽  
Francesca Pentimalli ◽  
Piero Tanganelli ◽  
Giulio Tarro ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Lung Cancer ◽  
Biomarker Discovery ◽  
Cancer Biomarker ◽  
The Road ◽  
Lung Cancer Biomarker

scholarly journals Application of Novel Methods for Non-Small Cell Lung Cancer (Nsclc) Biomarker Discovery

2013 ◽  
Vol 13 (1) ◽  
pp. 13-16
Author(s):  
Artjoms Spaks ◽  
Ainis Pirtnieks ◽  
Jelena Grusina-Ujumaza ◽  
Jazeps Basko ◽  
Dainis Krievins
Keyword(s):  
Lung Cancer ◽  
Postoperative Complications ◽  
Biomarker Discovery ◽  
Cancer Biomarker ◽  
Morbidity Rate ◽  
Control Group ◽  
New Approach ◽  
Lung Cancer Biomarker ◽  
Biomarker Research ◽  
Experimental Group

Summary Introduction. Research in NSCLC biomarker field and application of new methods is essential as it is promising strategy to reduce cancer mortality. Aim of the study. The aim of the study was to develop new approach for lung cancer biomarker research and introduce novel method into surgical practice, verifying method’s safety and evaluate intraoperative and postoperative complications. Materials and methods. 50 patients with early stage NSCLC undergoing lobectomy were randomized into two groups - experimental (n = 25) and control group (n = 25). In experimental group at the time of thoracotomy and resection of the lung, paired blood samples were obtained from the lobar pulmonary vein draining lung segment containing tumor and from the peripheral vein which represents the systemic circulation. Safety of the procedure and its influence on surgery was evaluated. Results. New approach for lung cancer biomarker research was developed. Injuries of major anatomical structures as pulmonary blood vessels, bronchi, trachea and pericardium due to blood sample collection were not observed. There was no difference in hospital stay and chest tube drainage duration. There were no perioperative deaths in both groups. Morbidity rate in experimental group was similar to control group. Conclusions. Application of new method for developing multimodal lung cancer model is safe and does not increase the risk of intraoperative and postoperative complications.

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