Hyperbranched Bisphosphonate‐Functional Polymers via Self‐Condensing Vinyl Polymerization and Postpolymerization Multicomponent Reactions

2020 ◽  
pp. 2000578
Author(s):  
Patricia R. Calvo ◽  
Chelsea A. Sparks ◽  
Justin Hochberg ◽  
Kenneth B. Wagener ◽  
Brent S. Sumerlin
Keyword(s):  
Multicomponent Reactions ◽  
Functional Polymers ◽  
Vinyl Polymerization

SuFExable Polymers with Helical Structures Derived from Thionyl Tetrafluoride (SOF4)

2019 ◽  
Author(s):  
Suhua Li ◽  
Gencheng Li ◽  
Bing Gao ◽  
Sidharam P. Pujari ◽  
Xiaoyan Chen ◽  
...  
Keyword(s):  
Functional Polymers ◽  
Polymer Chains ◽  
New Materials ◽  
Helical Structures ◽  
Polymer Backbone ◽  
Silyl Ethers ◽  
Helical Polymer ◽  
Key Characteristics ◽  
Post Modification ◽  
Individual Polymer

The first SuFEx click chemistry synthesis of SOF<sub>4</sub>-derived copolymers based upon the polymerization of bis(iminosulfur oxydifluorides) and bis(aryl silyl ethers) is described. This novel class of SuFEx polymer presents two key characteristics: First, the newly created [-N=S(=O)F-O-] polymer backbone linkages are themselves SuFExable and primed to undergo further high-yielding and precise SuFEx-based post-modification with phenols or amines to yield branched functional polymers. Second, studies of individual polymer chains of several of these new materials indicate the presence of helical polymer structures, which itself suggests a preferential approach of new monomers onto the growing polymer chain upon the formation of the stereogenic linking moiety.

Reactivity of Barbituric, Thiobarbituric Acids and Their Related Analogues: Synthesis of Substituted and Heterocycles-based Pyrimidines

2020 ◽  
Vol 24 (14) ◽  
pp. 1610-1642 ◽  
Author(s):  
Ahmed El-Mekabaty ◽  
Hassan A. Etman ◽  
Ahmed Mosbah ◽  
Ahmed A. Fadda
Keyword(s):  
Xanthine Oxidase ◽  
Multicomponent Reactions ◽  
Biological Activities ◽  
Present Review ◽  
Urease Inhibitors ◽  
Effective Catalyst ◽  
Inhibitory Activities ◽  
Catalyst Reusability ◽  
High Yields ◽  
Nano Catalysts

Barbituric, thiobarbituric acids and their related analogs are reactive synthons for the synthesis of drugs and biologically, and pharmaceutically active pyrimidines. The present review aimed to summarize the recent advances in the synthesis of different alkylsubstituted, fused cycles, spiro-, and binary heterocycles incorporated pyrimidine skeleton based on barbituric derivatives. In this sequence, the eco-friendly techniques under catalytic conditions were used for the diverse types of multicomponent reactions under different conditions for the synthesis of various types of heterocycles. Nano-catalysts are efficient for the synthesis of these compounds in high yields and effective catalyst reusability. The compounds are potent antibacterial, cytotoxic, xanthine oxidase inhibitory activities, and attend as urease inhibitors. The projected mechanisms for the synthesis of pyranopyrimidines, benzochromenopyrimidines, chromeno-pyranopyrimidines, spiroxyindoles, oxospiro-tricyclic furopyrimidines, pyrimidine-based monoand bicyclic pyridines were discussed. The potent and diverse biological activities for instance, antioxidant, antibacterial, cytotoxic, and xanthine oxidase inhibitory activities, as well as urease inhibitors, are specified.

Microwave Assisted Organic Synthesis: Cross Coupling and Multicomponent Reactions

2013 ◽  
Vol 17 (5) ◽  
pp. 474-490 ◽  
Author(s):  
Amit Kumar Gupta ◽  
Neetu Singh ◽  
Krishna Nand Singh
Keyword(s):  
Organic Synthesis ◽  
Multicomponent Reactions ◽  
Cross Coupling ◽  
Microwave Assisted

Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

2013 ◽  
Vol 16 (10) ◽  
pp. 788-790
Author(s):  
Zinatossadat Hossaini ◽  
Samereh Seyfi ◽  
Faramarz Rostami-Charati ◽  
Mehdi Ghambarian
Keyword(s):  
Multicomponent Reactions ◽  
Efficient Synthesis ◽  
One Pot ◽  
Imidazole Derivatives ◽  
New Class

Multicomponent Reactions in Antimitotic Drug Discovery

2014 ◽  
Vol 14 (20) ◽  
pp. 2209-2230 ◽  
Author(s):  
Angel Cores ◽  
Carlos Carbajales ◽  
Alberto Coelho
Keyword(s):  
Drug Discovery ◽  
Multicomponent Reactions ◽  
Antimitotic Drug

Recent Advances in the Synthesis of Pyrazole Derivatives Using Multicomponent Reactions

2017 ◽  
Vol 14 (5) ◽  
Author(s):  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda ◽  
Kranthi Kumar Gangu ◽  
Surya N. Maddila
Keyword(s):  
Multicomponent Reactions ◽  
Pyrazole Derivatives ◽  
Recent Advances

An Overview on Steroids and Microwave Energy in Multi-Component Reactions towards the Synthesis of Novel Hybrid Molecules

2020 ◽  
Vol 17 (8) ◽  
pp. 594-609
Author(s):  
Preetismita Borah ◽  
Vhatkar Dattatraya Shivling ◽  
Bimal Krishna Banik ◽  
Biswa Mohan Sahoo
Keyword(s):  
Energy Consumption ◽  
Multicomponent Reactions ◽  
Biological Activities ◽  
Vital Role ◽  
Microwave Energy ◽  
Biosynthetic Pathways ◽  
Chemical Transformations ◽  
Carbon Carbon Bond ◽  
Hybrid Molecules ◽  
Time Required

In recent years, hybrid systems are gaining considerable attention owing to their various biological applications in drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exist a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by nature through mixed biosynthetic pathways such as, a) integration of the different biosynthetic pathways or b) Carbon- Carbon bond formation between different components derived through different biosynthetic pathways. Multicomponent reactions are a great way to generate efficient libraries of hybrid compounds with high diversity. Throughout the scientific history, the most common factors developing technologies are less energy consumption and avoiding the use of hazardous reagents. In this case, microwave energy plays a vital role in chemical transformations since it involves two very essential criteria of synthesis, minimizing energy consumption required for heating and time required for the reaction. This review summarizes the use of microwave energy in the synthesis of steroidal and non-steroidal hybrid molecules and the use of multicomponent reactions.

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