Multicomponent Polymerization toward Cationic Polymers for Efficient Gene Delivery

2020 ◽  
pp. 2000464
Author(s):  
Nan Zheng ◽  
Daniel Kwesi Cudjoe ◽  
Wangze Song
Keyword(s):  
Gene Delivery ◽  
Cationic Polymers ◽  
Efficient Gene

scholarly journals Glycosylated Artificial Virus-Like Hybrid Vectors for Advanced Gene Delivery

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 243 ◽  
Author(s):  
Shashank Pinnapireddy ◽  
Mohamed Raafat El Assy ◽  
Patrick Schlote ◽  
Udo Bakowsky
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Transfection Efficiency ◽  
Viral Envelope ◽  
Specific Gene ◽  
Cationic Polymers ◽  
Hybrid Vectors ◽  
Efficient Gene ◽  
Delivery Vehicles ◽  
Viral Envelopes

The major obstacle facing efficient gene therapy is the development of reliable delivery vehicles, which are both nontoxic and biocompatible and possess efficient cell-specific gene delivery. Previously, hybrid delivery vehicles comprising anionic liposomes and cationic polymers have been used successfully for gene therapy. In this study, hybrid vectors based on glycosylated artificial viral envelopes (including two novel compositions mimicking HIV and HSV envelopes) and polyethylenimine were morphologically and physiologically characterised. Transfection studies showed that the hybrid vectors based on the control liposomes, and their glycosylated modifications, had significantly higher transfection rates compared to the polyplexes. Improvement in the transfection efficiency was observed with the glycosylated HIV- and HSV-mimicking hybrid vectors, which also showed a safe biocompatibility profile based on the cytotoxicity and haemocompatibility assays. These glycosylated artificial viral envelope-based hybrid vectors could be used as safe gene delivery systems with potential to become new compositions for efficient nonviral gene therapy.

Solely aqueous formulation of hydrophobic cationic polymers for efficient gene delivery

2021 ◽  
Vol 593 ◽  
pp. 120080
Author(s):  
Jana I. Solomun ◽  
Gizem Cinar ◽  
Prosper Mapfumo ◽  
Friederike Richter ◽  
Elisabeth Moek ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Polymers ◽  
Efficient Gene

Cross-linked polymers with fluorinated bridges for efficient gene delivery

2017 ◽  
Vol 5 (43) ◽  
pp. 8542-8553 ◽  
Author(s):  
Ya-Ping Xiao ◽  
Ji Zhang ◽  
Yan-Hong Liu ◽  
Zheng Huang ◽  
Bing Wang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cationic Polymers ◽  
Efficient Gene ◽  
New Strategy

A new strategy for the construction of fluorinated cationic polymers for gene delivery was introduced.

Polyplex: A Promising Gene Delivery System

2019 ◽  
Vol 12 (6) ◽  
pp. 4681-4686
Author(s):  
Rohan Aggarwal ◽  
Monika Targhotra ◽  
Bhumika Kumar ◽  
P.K Sahoo ◽  
Meenakshi K Chauhan
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
Delivery System ◽  
Viral Vectors ◽  
Gene Delivery System ◽  
Cationic Polymers ◽  
Therapeutic Application ◽  
Promising Alternative ◽  
Structure And Stability ◽  
The Past

In the past few years gene delivery system has gained a huge attention owing to its proved efficacy in several diseases especially in those caused by genetic and/oroncological malfunctioning. The effective gene delivery mainly depends on the carrier molecules that can ensure the safe and specific delivery of the nucleic acidmolecules. Viral vectors have been used for a longer period as the gene transfer vehicle. However, these viral vectors have potential immunological disadvantages that made them less preferred. Recently, non-viral vectors such as polyplexes have emerged as a promising alternative for viral vectors. Polyplexes are formed by conjugating a polymer with DNA and in maximum cases the cationic polymers are preferred over others. The structure and stability of the polyplexes depends on various factors. The ability of the polymer to condense the DNA mainly dictates the efficiency of the polyplex mediated transfection. In this review we are going to provide a framework for the synthesis and design of the polyplexes along with the structure and stability of the complexes pertaining to mechanism of action, characterization and therapeutic application, including polyethyleneimine mediated cytotoxicity as well as newer strategies for the generation of better polyplexes.

Amino acids functionalized dendrimers with nucleus accumulation for efficient gene delivery

2021 ◽  
pp. 120641
Author(s):  
Guoxin Tan ◽  
Jiayang Li ◽  
Dandan Liu ◽  
Hao Pan ◽  
Renfang Zhu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Gene Delivery ◽  
Efficient Gene

scholarly journals Carbon Dot Nanoparticles: Exploring the Potential Use for Gene Delivery in Ophthalmic Diseases

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 935
Author(s):  
Manas R. Biswal ◽  
Sofia Bhatia
Keyword(s):  
Gene Delivery ◽  
Therapeutic Option ◽  
Retinal Dystrophy ◽  
Retinal Cells ◽  
Adeno Associated Virus ◽  
Inherited Retinal Dystrophies ◽  
Retinal Dystrophies ◽  
Efficient Gene ◽  
New Type ◽  
Viral Nanoparticles

Ocular gene therapy offers significant potential for preventing retinal dystrophy in patients with inherited retinal dystrophies (IRD). Adeno-associated virus (AAV) based gene transfer is the most common and successful gene delivery approach to the eye. These days, many studies are using non-viral nanoparticles (NPs) as an alternative therapeutic option because of their unique properties and biocompatibility. Here, we discuss the potential of carbon dots (CDs), a new type of nanocarrier for gene delivery to the retinal cells. The unique physicochemical properties of CDs (such as optical, electronic, and catalytic) make them suitable for biosensing, imaging, drug, and gene delivery applications. Efficient gene delivery to the retinal cells using CDs depends on various factors, such as photoluminescence, quantum yield, biocompatibility, size, and shape. In this review, we focused on different approaches used to synthesize CDs, classify CDs, various pathways for the intake of gene-loaded carbon nanoparticles inside the cell, and multiple studies that worked on transferring nucleic acid in the eye using CDs.

Polyethylenimine-poly(amidoamine) dendrimer modified with l-arginines as an efficient gene delivery vector

2015 ◽  
Vol 23 (8) ◽  
pp. 726-733 ◽  
Author(s):  
Nan Young Ahn ◽  
Tae-Hun Kim ◽  
Su Jeong Song ◽  
Jeong-Mi Moon ◽  
Tai Hwan Ha ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Efficient Gene
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