Thermal and Reactive Oxygen Species Dual‐Responsive OEGylated Polysulfides with Oxidation‐Tunable Lower Critical Solution Temperatures

2020 ◽  
Vol 41 (13) ◽  
pp. 2000206
Author(s):  
Runhai Chen ◽  
Zehong Xiang ◽  
Yu Xia ◽  
Zhifang Ma ◽  
Qiang Shi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive ◽  
Critical Solution Temperatures

scholarly journals Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy

2020 ◽  
Vol 324 ◽  
pp. 330-340 ◽  
Author(s):  
Ning Zhao ◽  
Bingbing Ding ◽  
Ying Zhang ◽  
Jessica L. Klockow ◽  
Ken Lau ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive

Synthesis of thermal and oxidation dual responsive polymers for reactive oxygen species (ROS)-triggered drug release

2015 ◽  
Vol 6 (5) ◽  
pp. 738-747 ◽  
Author(s):  
Chunsheng Xiao ◽  
Jianxun Ding ◽  
Lili Ma ◽  
Chenguang Yang ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Main Chain ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Responsive Polymers ◽  
Dual Responsive ◽  
Responsive Polymer ◽  
Triggered Drug Release

A PEG-based main chain thermo-responsive polymer with oxidation-triggerable thioether groups: synthesis, characterization and its use for ROS-responsive drug release.

Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy

2021 ◽  
Vol 123 ◽  
pp. 111956
Author(s):  
Liuhui Zhang ◽  
Shiqiang Zhang ◽  
Mengxiong Li ◽  
Yamei Li ◽  
Haiyun Xiong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive ◽  
Prostate Cancer Therapy

scholarly journals Dual-responsive nanoparticles release cargo upon exposure to matrix metalloproteinase and reactive oxygen species

2016 ◽  
Vol 52 (10) ◽  
pp. 2126-2128 ◽  
Author(s):  
Kevin B. Daniel ◽  
Cassandra E. Callmann ◽  
Nathan C. Gianneschi ◽  
Seth M. Cohen
Keyword(s):  
Reactive Oxygen Species ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Inflammatory Diseases ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive ◽  
Micellar Nanoparticles

Micellar nanoparticles were designed to be responsive to matrix metalloproteinases (MMPs) and reactive oxygen species (ROS), each of which is upregulated in the pathology of inflammatory diseases.

Mitochondria as a source of reactive oxygen species

2009 ◽  
pp. c3 ◽  
Author(s):  
Helena M. Cochemé ◽  
Michael P. Murphy
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species

Clinical aspects of reactive oxygen and nitrogen species

2004 ◽  
Vol 71 ◽  
pp. 121-133 ◽  
Author(s):  
Ascan Warnholtz ◽  
Maria Wendt ◽  
Michael August ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Vascular Tissue ◽  
Rapid Development ◽  
Reactive Oxygen ◽  
Clinical Aspects ◽  
No Production ◽  
Oxygen Species

Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia, and the subsequent decrease in vascular bioavailability of NO. Superoxide-producing enzymes involved in increased oxidative stress within vascular tissue include NAD(P)H-oxidase, xanthine oxidase and endothelial nitric oxide synthase in an uncoupled state. Recent studies indicate that endothelial dysfunction of peripheral and coronary resistance and conductance vessels represents a strong and independent risk factor for future cardiovascular events. Ways to reduce endothelial dysfunction include risk-factor modification and treatment with substances that have been shown to reduce oxidative stress and, simultaneously, to stimulate endothelial NO production, such as inhibitors of angiotensin-converting enzyme or the statins. In contrast, in conditions where increased production of reactive oxygen species, such as superoxide, in vascular tissue is established, treatment with NO, e.g. via administration of nitroglycerin, results in a rapid development of endothelial dysfunction, which may worsen the prognosis in patients with established coronary artery disease.

Fas ligand expression in rat kupffer cells in response to lipopolysaccharide is mediated by reactive oxygen species

2001 ◽  
Vol 120 (5) ◽  
pp. A361-A361
Author(s):  
K UCHIKURA ◽  
T WADA ◽  
Z SUN ◽  
S HOSHINO ◽  
G BULKLEY ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Kupffer Cells ◽  
Fas Ligand ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ligand Expression
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