Multiple Hydrogen Bonds–Reinforced Hydrogels with High Strength, Shape Memory, and Adsorption Anti‐Inflammatory Molecules

2020 ◽  
Vol 41 (14) ◽  
pp. 2000202 ◽  
Author(s):  
Xuefeng Li ◽  
Xueyin Peng ◽  
Rongzhe Li ◽  
Yikun Zhang ◽  
Zuifang Liu ◽  
...  
Keyword(s):  
Hydrogen Bonds ◽  
Shape Memory ◽  
High Strength ◽  
Anti Inflammatory ◽  
Inflammatory Molecules ◽  
Multiple Hydrogen Bonds

High Strength Multifunctional Multiwalled Hydrogel Tubes: Ion-Triggered Shape Memory, Antibacterial, and Anti-inflammatory Efficacies

2015 ◽  
Vol 7 (30) ◽  
pp. 16865-16872 ◽  
Author(s):  
Bing Xu ◽  
Yongmao Li ◽  
Fei Gao ◽  
Xinyun Zhai ◽  
Mengge Sun ◽  
...  
Keyword(s):  
Shape Memory ◽  
High Strength ◽  
Anti Inflammatory

Tunable “soft and stiff”, self-healing, recyclable, thermadapt shape memory biomass polymers based on multiple hydrogen bonds and dynamic imine bonds

2019 ◽  
Vol 7 (21) ◽  
pp. 13400-13410 ◽  
Author(s):  
Fei Song ◽  
Zhaoshuang Li ◽  
Puyou Jia ◽  
Meng Zhang ◽  
Caiying Bo ◽  
...  
Keyword(s):  
Hydrogen Bonds ◽  
Shape Memory ◽  
Self Healing ◽  
Healing Efficiency ◽  
Multiple Hydrogen Bonds

We synthesized “thermadapt” biomass polymers with shape memory, ultrahigh stretchability or rigidity, remarkable self-healing efficiency, recyclability, and reusable adhesiveness.

scholarly journals Lactobacillus acidophilus LA5 improves saturated fat-induced obesity mouse model through the enhanced intestinal Akkermansia muciniphila

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Thunnicha Ondee ◽  
Krit Pongpirul ◽  
Peerapat Visitchanakun ◽  
Wilasinee Saisorn ◽  
Suthicha Kanacharoen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Lactobacillus Acidophilus ◽  
Hepg2 Cells ◽  
Saturated Fat ◽  
Liver Weight ◽  
Gram Negative ◽  
Fecal Microbiome ◽  
Akkermansia Muciniphila ◽  
Anti Inflammatory ◽  
Inflammatory Molecules

AbstractObesity, a major healthcare problem worldwide, induces metabolic endotoxemia through the gut translocation of lipopolysaccharides (LPS), a major cell wall component of Gram-negative bacteria, causing a chronic inflammatory state. A combination of several probiotics including Lactobacillus acidophilus 5 (LA5), a potent lactic acid-producing bacterium, has previously been shown to attenuate obesity. However, data on the correlation between a single administration of LA5 versus microbiota alteration might be helpful for the probiotic adjustment. LA5 was administered daily together with a high-fat diet (HFD) for 8 weeks in mice. Furthermore, the condition media of LA5 was also tested in a hepatocyte cell-line (HepG2 cells). Accordingly, LA5 attenuated obesity in mice as demonstrated by weight reduction, regional fat accumulation, lipidemia, liver injury (liver weight, lipid compositions, and liver enzyme), gut permeability defect, endotoxemia, and serum cytokines. Unsurprisingly, LA5 improved these parameters and acidified fecal pH leads to the attenuation of fecal dysbiosis. The fecal microbiome analysis in obese mice with or without LA5 indicated; (i) decreased Bacteroidetes (Gram-negative anaerobes that predominate in non-healthy conditions), (ii) reduced total fecal Gram-negative bacterial burdens (the sources of gut LPS), (iii) enhanced Firmicutes (Gram-positive bacteria with potential benefits) and (iv) increased Verrucomycobia, especially Akkermansia muciniphila, a bacterium with the anti-obesity property. With LA5 administration, A. muciniphila in the colon were more than 2,000 folds higher than the regular diet mice as determined by 16S rRNA. Besides, LA5 produced anti-inflammatory molecules with a similar molecular weight to LPS that reduced cytokine production in LPS-activated HepG2 cells. In conclusion, LA5 attenuated obesity through (i) gut dysbiosis attenuation, partly through the promotion of A. muciniphila (probiotics with the difficulty in preparation processes), (ii) reduced endotoxemia, and (iii) possibly decreased liver injury by producing the anti-inflammatory molecules.

scholarly journals Experimental Study and Modeling of the Fatigue Fracture of High-Strength FeMnSi-based Shape Memory Alloy

2020 ◽  
Vol 28 ◽  
pp. 2110-2117
Author(s):  
Fedor S. Belyaev ◽  
Margarita E. Evard ◽  
Eugeny S. Ostropiko ◽  
Aleksandr E. Volkov
Keyword(s):  
Experimental Study ◽  
Shape Memory Alloy ◽  
Shape Memory ◽  
Fatigue Fracture ◽  
High Strength

scholarly journals Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 991
Author(s):  
Melanie S. Matos ◽  
José D. Anastácio ◽  
Cláudia Nunes dos Santos
Keyword(s):  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Physiological State ◽  
Plant Secondary Metabolites ◽  
Inflammatory Pathways ◽  
Inflammatory State ◽  
Anti Inflammatory ◽  
Inflammatory Molecules

Inflammation is a crucial and complex process that reestablishes the physiological state after a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to chronic inflammation and causing tissue damage. Sesquiterpene lactones (SLs) are composed of a large and diverse group of highly bioactive plant secondary metabolites, characterized by a 15-carbon backbone structure. In recent years, the interest in SLs has risen due to their vast array of biological activities beneficial for human health. The anti-inflammatory potential of these compounds results from their ability to target and inhibit various key pro-inflammatory molecules enrolled in diverse inflammatory pathways, and prevent or reduce the inflammatory damage on tissues. Research on the anti-inflammatory mechanisms of SLs has thrived over the last years, and numerous compounds from diverse plants have been studied, using in silico, in vitro, and in vivo assays. Besides their anti-inflammatory potential, their cytotoxicity, structure–activity relationships, and pharmacokinetics have been investigated. This review aims to gather the most relevant results and insights concerning the anti-inflammatory potential of SL-rich extracts and pure SLs, focusing on their effects in different inflammatory pathways and on different molecular players.

Self-healing, pH-sensitive and shape memory hydrogels based on acylhydrazone and hydrogen bonds

2021 ◽  
pp. 110838
Author(s):  
Liyuan Qiao ◽  
Chengde Liu ◽  
Cheng Liu ◽  
Lishuai Zong ◽  
Hongjian Gu ◽  
...  
Keyword(s):  
Hydrogen Bonds ◽  
Shape Memory ◽  
Ph Sensitive ◽  
Self Healing

Martensitic transformations γ-ɛ (α) and the shape-memory effect in aging high-strength manganese austenitic steels

2008 ◽  
Vol 106 (6) ◽  
pp. 630-640 ◽  
Author(s):  
V. V. Sagaradze ◽  
V. I. Voronin ◽  
Yu. I. Filippov ◽  
V. A. Kazantsev ◽  
M. L. Mukhin ◽  
...  
Keyword(s):  
Shape Memory ◽  
Shape Memory Effect ◽  
Memory Effect ◽  
High Strength ◽  
Martensitic Transformations ◽  
Austenitic Steels

Effects of aging on the shape memory and superelasticity behavior of ultra-high strength Ni 54 Ti 46 alloys under compression

2016 ◽  
Vol 678 ◽  
pp. 93-100 ◽  
Author(s):  
I. Kaya ◽  
H. Tobe ◽  
H.E. Karaca ◽  
B. Basaran ◽  
M. Nagasako ◽  
...  
Keyword(s):  
Shape Memory ◽  
High Strength ◽  
Effects Of Aging

scholarly journals Towards understanding of delignification of grassy and woody biomass in cholinium-based ionic liquids

2021 ◽  
Author(s):  
Mood Mohan ◽  
Hemant Choudhary ◽  
Anthe George ◽  
Blake A. Simmons ◽  
Kenneth Sale ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Ionic Liquids ◽  
Hydrogen Bonds ◽  
Molecular Dynamics Simulations ◽  
Woody Biomass ◽  
Dissolution Mechanism ◽  
Dynamics Simulations ◽  
Multiple Hydrogen Bonds

Herein we report the dissolution mechanism of lignin in cholinium-based ionic liquids by molecular dynamics simulations. Multiple hydrogen bonds, longer HB lifetimes, and higher pKa of [Ch][Lys] makes it a better solvent for lignin than acidic ILs.

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