Self-Assembly Drug Delivery System Based on Programmable Dendritic Peptide Applied in Multidrug Resistance Tumor Therapy

2017 ◽  
Vol 38 (21) ◽  
pp. 1700490 ◽  
Author(s):  
Si Chen ◽  
Jin-Xuan Fan ◽  
Wen-Xiu Qiu ◽  
Li-Han Liu ◽  
Han Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multidrug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Tumor Therapy

scholarly journals Environment Responsive Metal–Organic Frameworks as Drug Delivery System for Tumor Therapy

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Chao Yan ◽  
Yue Jin ◽  
Chuanxiang Zhao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Tumor Therapy ◽  
Metal Organic Frameworks ◽  
Delivery Systems ◽  
Drug Uptake ◽  
High Concentration ◽  
Metal Organic

AbstractNanoparticles as drug delivery systems can alter the drugs' hydrophilicity to affect drug uptake and efflux in tissues. They prevent drugs from non-specifically binding with bio-macromolecules and enhance drug accumulation at the lesion sites, improving therapy effects and reducing unnecessary side effects. Metal–organic frameworks (MOFs), the typical nanoparticles, a class of crystalline porous materials via self-assembled organic linkers and metal ions, exhibit excellent biodegradability, pore shape and sizes, and finely tunable chemical composition. MOFs have a rigid molecular structure, and tunable pore size can improve the encapsulation drug's stability under harsh conditions. Besides, the surface of MOFs can be modified with small-molecule ligands and biomolecule, and binding with the biomarkers which is overexpressed on the surface of cancer cells. MOFs formulations for therapeutic have been developed to effectively respond to the unique tumor microenvironment (TEM), such as high H2O2 levels, hypoxia, and high concentration glutathione (GSH). Thus, MOFs as a drug delivery system should avoid drugs leaking during blood circulation and releasing at the lesion sites via a controlling manner. In this article, we will summary environment responsive MOFs as drug delivery systems for tumor therapy under different stimuli.

scholarly journals Nanoparticulate targeted drug delivery systems - A Review

2020 ◽  
Vol 11 (2) ◽  
pp. 2505-2518
Author(s):  
Sindhuja Devaraj ◽  
Ganesh GNK
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Developing System ◽  
General Method

Nanoparticulate drug delivery system are the rapidly developing system, and nanoparticles are present in the size range of 1-100nm. Nanoparticles composed of various thermal, electrical, and optical property. Nanoparticles offers the potential advantages over the traditional dosage forms it is ascribable to the properties of nanoparticles. Nanoparticulate drug delivery system ensures the site-specific delivery of a drug(Targeting drug delivery) and aids in improving the efficacy of the new as well as old drugs and has the potential in crossing the various physiological barriers and also improves the therapeutic index of the drugs and increases the patient compliance. The objectives of this review is to classify the nanoparticles based on the different groups, surface properties of nanoparticles, describe the strategies of drug targeting, the necessity of nanoparticles their general method of preparation, different methods used in characterization, self- assembly and mechanism of drug release in a systemic manner. The potential advantages and limitations of various nanoparticulate drug delivery systems are also discussed elaborately.

scholarly journals Reactive oxygen species and enzyme dual-responsive biocompatible drug delivery system for targeted tumor therapy

2020 ◽  
Vol 324 ◽  
pp. 330-340 ◽  
Author(s):  
Ning Zhao ◽  
Bingbing Ding ◽  
Ying Zhang ◽  
Jessica L. Klockow ◽  
Ken Lau ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Therapy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Dual Responsive

scholarly journals Injectable Drug Delivery System Based on in Situ Self‐Assembly of Liquid Star PEG‐PLGA

2020 ◽  
pp. 2000069
Author(s):  
Bat-Hen Eylon ◽  
Alona Shagan ◽  
Ayelet Shabtay-Orbach ◽  
Adi Gross ◽  
Boaz Mizrahi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Assembly ◽  
Injectable Drug

Self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system for bone repair materials

2017 ◽  
Vol 5 (12) ◽  
pp. 2245-2253 ◽  
Author(s):  
Yi-Xuan Chen ◽  
Rong Zhu ◽  
Zheng-liang Xu ◽  
Qin-Fei Ke ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Self Assembly ◽  
Bone Repair ◽  
Repair Materials ◽  
Double Hydroxide ◽  
First Time ◽  
Bone Repair Materials

The self-assembly of pifithrin-α-loaded layered double hydroxide/chitosan nanohybrid composites as a drug delivery system was demonstrated for the first time to improve the cytocompatibility and enhance the osteoinductivity for the treatment of bone defects.

Overcoming multidrug resistance by a combination of chemotherapy and photothermal therapy mediated by carbon nanohorns

2016 ◽  
Vol 4 (36) ◽  
pp. 6043-6051 ◽  
Author(s):  
Junling Wang ◽  
Ran Wang ◽  
Fangrong Zhang ◽  
Yajun Yin ◽  
Leixia Mei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multidrug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Photothermal Therapy ◽  
Carbon Nanohorns ◽  
P Glycoprotein ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

A targeted drug delivery system based on carbon nanohorns for targeting P-glycoprotein and delivering etoposide into cells to overcome multidrug resistance.

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