One-Pot Preparation of Inert Well-Defined Polymers by RAFT Polymerization and In Situ End Group Transformation

2015 ◽  
Vol 36 (12) ◽  
pp. 1177-1183 ◽  
Author(s):  
Qilu Zhang ◽  
Lenny Voorhaar ◽  
Bruno G. De Geest ◽  
Richard Hoogenboom
Keyword(s):  
Raft Polymerization ◽  
One Pot ◽  
Group Transformation ◽  
End Group

A facile one pot strategy for the synthesis of well-defined polyacrylates from acrylic acid via RAFT polymerization

2014 ◽  
Vol 50 (25) ◽  
pp. 3331-3334 ◽  
Author(s):  
Qianbiao Li ◽  
Taisheng Wang ◽  
Jingwen Dai ◽  
Chao Ma ◽  
Bangkun Jin ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Raft Polymerization ◽  
Halogenated Compounds ◽  
One Pot ◽  
Hyperbranched Polyacrylates

Linear and hyperbranched polyacrylates were successfully synthesized by the combination of in situ esterification of acrylic acid with halogenated compounds promoted by 1,1,3,3-tetramethylguanidine (TMG) and RAFT polymerization.

A Novel One-Pot Procedure for the Fast and Efficient Conversion of RAFT Polymers into Hydroxy-Functional Polymers

2009 ◽  
Vol 62 (8) ◽  
pp. 806 ◽  
Author(s):  
Till Gruendling ◽  
Mathias Dietrich ◽  
Christopher Barner-Kowollik
Keyword(s):  
Elevated Temperatures ◽  
Raft Polymerization ◽  
Functional Polymers ◽  
Size Exclusion ◽  
One Pot ◽  
Reversible Addition ◽  
Exclusion Chromatography ◽  
Azo Initiator ◽  
Raft Polymers ◽  
End Group

We report on the successful quantitative transformation of methacrylate and acrylate-type polymers prepared by reversible addition–fragmentation chain transfer (RAFT) polymerization carrying a dithioester-end-group into hydroxy-functional polymers. The simple reaction procedure involves stirring a solution of the dithioester-capped polymer and an azo-initiator in tetrahydrofuran at elevated temperatures (T = 60°C) in the presence of air. This reaction quantitatively yields hydroperoxide functionalities that can be efficiently reduced to hydroxy groups in a one-pot procedure using triphenylphosphine. Size exclusion chromatography–electrospray mass spectrometry was employed to monitor the progress of the reaction. The new backbone-linked hydroxy group provides a versatile anchor for chemical end-group conversions and conjugation reactions with prepared RAFT polymers, which alleviates problems with the rather limited ability of the dithioester-end-group to undergo non-radical transformations.

Indium Bromide-catalyzed Unprecedented Hydrogenolysis: A Novel One-Pot Synthesis of Per-O-Acetylated β-carboxymethyl O and S-glycosides

2020 ◽  
Vol 24 (8) ◽  
pp. 900-908
Author(s):  
Ram Naresh Yadav ◽  
Amrendra K Singh ◽  
Bimal Banik
Keyword(s):  
Asymmetric Synthesis ◽  
Chiral Auxiliary ◽  
Bioactive Molecules ◽  
One Pot ◽  
Enantiomerically Pure ◽  
Stereoselective Glycosylation ◽  
One Pot Synthesis ◽  
Wide Range

Numerous O (oxa)- and S (thia)-glycosyl esters and their analogous glycosyl acids have been accomplished through stereoselective glycosylation of various peracetylated bromo sugar with benzyl glycolate using InBr3 as a glycosyl promotor followed by in situ hydrogenolysis of resulting glycosyl ester. A tandem glycosylating and hydrogenolytic activity of InBr3 has been successfully investigated in a one-pot procedure. The resulting synthetically valuable and virtually unexplored class of β-CMGL (glycosyl acids) could serve as an excellent potential chiral auxiliary in the asymmetric synthesis of a wide range of enantiomerically pure medicinally prevalent β-lactams and other bioactive molecules of diverse medicinal interest.

scholarly journals Aqueous one-pot synthesis of well-defined zwitterionic diblock copolymers by RAFT polymerization: an efficient and environmentally-friendly route to a useful dispersant for aqueous pigments

2021 ◽  
Vol 23 (3) ◽  
pp. 1248-1258
Author(s):  
Shannon M. North ◽  
Steven P. Armes
Keyword(s):  
Iron Oxide ◽  
Diblock Copolymers ◽  
Raft Polymerization ◽  
Environmentally Friendly ◽  
Iron Oxide Particles ◽  
One Pot ◽  
One Pot Synthesis ◽  
Highly Effective ◽  
Oxide Particles

An atom-efficient, wholly aqueous one-pot synthesis of zwitterionic diblock copolymers has been devised. Such copolymers can serve as highly effective aqueous dispersants for nano-sized transparent yellow iron oxide particles.

scholarly journals NIR responsive tumor vaccine in situ for photothermal ablation and chemotherapy to trigger robust antitumor immune responses

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Lirong Zhang ◽  
Jingjing Zhang ◽  
Lixia Xu ◽  
Zijian Zhuang ◽  
Jingjin Liu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Tumor Vaccine ◽  
Oxidative Polymerization ◽  
Delivery Mode ◽  
Tumor Treatment ◽  
One Pot ◽  
Photothermal Ablation ◽  
Prolonged Retention ◽  
The One

Abstract Background Therapeutic tumor vaccine (TTV) that induces tumor-specific immunity has enormous potentials in tumor treatment, but high heterogeneity and poor immunogenicity of tumor seriously impair its clinical efficacy. Herein, a novel NIR responsive tumor vaccine in situ (HA-PDA@IQ/DOX HG) was prepared by integrating hyaluronic acid functionalized polydopamine nanoparticles (HA-PDA NPs) with immune adjuvants (Imiquimod, IQ) and doxorubicin (DOX) into thermal-sensitive hydrogel. Results HA-PDA@IQ NPs with high photothermal conversion efficiency (41.2%) and T1-relaxation efficiency were using HA as stabilizer by the one-pot oxidative polymerization. Then, HA-PDA@IQ loaded DOX via π-π stacking and mixed with thermal-sensitive hydrogel to form the HA-PDA@IQ/DOX HG. The hydrogel-confined delivery mode endowed HA-PDA@IQ/DOX NPs with multiple photothermal ablation performance once injection upon NIR irradiation due to the prolonged retention in tumor site. More importantly, this mode enabled HA-PDA@IQ/DOX NPs to promote the DC maturation, memory T cells in lymphatic node as well as cytotoxic T lymphocytes in spleen. Conclusion Taken together, the HA-PDA@IQ/DOX HG could be served as a theranostic tumor vaccine for complete photothermal ablation to trigger robust antitumor immune responses.

scholarly journals Thermally-induced hyperbranching of bromine-containing polyesters by insertion of in situ generated chain-end carbenes

2021 ◽  
Author(s):  
Panos Bexis ◽  
Craig Bell ◽  
Maria Chiara Arno ◽  
Anthony Thomas ◽  
Andrew P Dove
Keyword(s):  
Thermally Induced ◽  
End Group

Hyperbranched, biodegradable PCL-based polymers are obtained through a random but invasive migration of an in-situ generated carbene end group which is unmasked via the thermolysis of its precursor diazirine moiety....

scholarly journals PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation

2021 ◽  
pp. 174751982098753
Author(s):  
Xiaofang Wu ◽  
Lei Zhou ◽  
Fangshao Li ◽  
Jing Xiao
Keyword(s):  
Acid Chloride ◽  
Bioactive Molecules ◽  
Mechanistic Studies ◽  
One Pot ◽  
Tert Butyl ◽  
Butyl Esters

A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.

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