Poly(2-vinyl pyridine)-block-Poly(ethylene oxide) Featuring a Furan Group at the Block Junction-Synthesis and Functionalization

2014 ◽  
Vol 35 (9) ◽  
pp. 916-921 ◽  
Author(s):  
Tobias Rudolph ◽  
Markus J. Barthel ◽  
Florian Kretschmer ◽  
Ulrich Mansfeld ◽  
Stephanie Hoeppener ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Vinyl Pyridine ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Crystallization and Physical Ageing of Poly (2-vinyl pyridine)-b -poly(ethylene oxide) Diblock Copolymers

2010 ◽  
Vol 287 (1) ◽  
pp. 101-106 ◽  
Author(s):  
Miguel Córdova ◽  
Arnaldo T. Lorenzo ◽  
Alejandro J. Müller ◽  
Panagiota Fragouli ◽  
Hermis Iatrou ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Diblock Copolymers ◽  
Physical Ageing ◽  
Vinyl Pyridine ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

scholarly journals Drug Delivery System Based on pH-Sensitive Biocompatible Poly(2-vinyl pyridine)-b-poly(ethylene oxide) Nanomicelles Loaded with Curcumin and 5-Fluorouracil

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1450 ◽  
Author(s):  
Camelia-Elena Iurciuc-Tincu ◽  
Monica Stamate Cretan ◽  
Violeta Purcar ◽  
Marcel Popa ◽  
Oana Maria Daraba ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Ethylene Oxide ◽  
Ph Sensitive ◽  
Hydrophobic Drugs ◽  
Practical Utilization ◽  
Vinyl Pyridine ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Smart polymeric micelles (PMs) are of practical interest as nanocarriers for the encapsulation and controlled release of hydrophobic drugs. Two hydrophobic drugs, naturally-based curcumin (Cur) and synthetic 5-fluorouracil (5-FU), were loaded into the PMs formed by a well-defined pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP90-b-PEO398) block copolymer. The influence of the drug loading on the micellar sizes was investigated by dynamic light scattering (DLS) and it appears that the size of the PMs increases from around 60 to 100 nm when Cur is loaded. On the contrary, the loading of the 5-FU has a smaller effect on the micellar sizes. This difference can be attributed to higher molar mass of Cur with respect to 5-FU but also to higher loading efficiency of Cur, 6.4%, compared to that of 5-FU, 5.8%. In vitro drug release was studied at pH 2, 6.8, and 7.4, and it was observed that the pH controls the release of both drugs. At pH 2, where the P2VP sequences from the “frozen-in” micellar core are protonated, the drug release efficiencies exceed 90%. Moreover, it was demonstrated, by in vitro assays, that these PMs are hemocompatible and biocompatible. Furthermore, the PMs protect the Cur against the photo-degradation, whereas the non-ionic PEO corona limits the adsorption of bovine serum albumin (BSA) protein on the surface. This study demonstrates that these pH-sensitive PMs are suitable for practical utilization as human-safe and smart, injectable drug delivery systems.

Blends of PEO in Poly(ethylene oxide)∕Poly(2-vinyl pyridine)-b-poly(ethylene oxide)

2010 ◽  
Author(s):  
E. Araneda ◽  
L. Gargallo ◽  
A. Leiva ◽  
N. Hadjichristidis ◽  
I. Mondragon ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Vinyl Pyridine ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Conductivities of Poly (Ethylene Oxide) and Poly (2-Vinyl Pyridine) Blend

1996 ◽  
Vol 33 (3) ◽  
pp. 247-259 ◽  
Author(s):  
Min-Hui Cui ◽  
Dong-Hua Cheng ◽  
Jun-She Guo ◽  
Hong-Quan Xie
Keyword(s):  
Ethylene Oxide ◽  
Vinyl Pyridine ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Crystallization behavior of PEO in blends of poly(ethylene oxide)/poly(2-vinyl pyridine)-b -(ethylene oxide) block copolymer

2011 ◽  
Vol 52 (5) ◽  
pp. 1128-1136 ◽  
Author(s):  
Emilio Araneda ◽  
Angel Leiva ◽  
Ligia Gargallo ◽  
Nikos Hadjichristidis ◽  
Iñaki Mondragon ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Oxide ◽  
Crystallization Behavior ◽  
Vinyl Pyridine ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

The Structure of Radiation Cross-Linked Poly (ethylene oxide) Gels

1971 ◽  
Vol 29 ◽  
pp. 76-77
Author(s):  
C. E. Cluthe ◽  
G. G. Cocks
Keyword(s):  
Molecular Weight ◽  
Ethylene Oxide ◽  
Parallel Plate ◽  
Average Molecular Weight ◽  
Radical Reaction ◽  
Free Radical Reaction ◽  
Nitrogen Gas ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene ◽  
Initial Viscosity

Aqueous solutions of a 1 weight-per cent poly (ethylene oxide) (PEO) were degassed under vacuum, transferred to a parallel plate viscometer under a nitrogen gas blanket, and exposed to Co60 gamma radiation. The Co60 source was rated at 4000 curies, and the dose ratewas 3.8x105 rads/hr. The poly (ethylene oxide) employed in the irradiations had an initial viscosity average molecular weight of 2.1 x 106.The solutions were gelled by a free radical reaction with dosages ranging from 5x104 rads to 4.8x106 rads.

Preparation of Organized Mesoporous Silica from Sodium Metasilicate Solutions in Alkaline Medium Using Nonionic Surfactants

2003 ◽  
Vol 68 (10) ◽  
pp. 2019-2031 ◽  
Author(s):  
Markéta Zukalová ◽  
Jiří Rathouský ◽  
Arnošt Zukal
Keyword(s):  
Mesoporous Silica ◽  
Ethylene Oxide ◽  
Sodium Metasilicate ◽  
Spherical Particles ◽  
Structure Directing Agent ◽  
Inorganic Species ◽  
Poly Ethylene Oxide ◽  
Acidic Conditions ◽  
Poly Ethylene ◽  
Hydrolysis Of

A new procedure has been developed, which is based on homogeneous precipitation of organized mesoporous silica from an aqueous solution of sodium metasilicate and a nonionic poly(ethylene oxide) surfactant serving as a structure-directing agent. The decrease in pH, which induces the polycondensation of silica, is achieved by hydrolysis of ethyl acetate. Owing to the complexation of Na+ cations by poly(ethylene oxide) segments, assembling of the mesostructure appears to occur under electrostatic control by the S0Na+I- pathway, where S0 and I- are surfactant and inorganic species, respectively. As the complexation of Na+ cations causes extended conformation of poly(ethylene oxide) segments, the pore size and pore volume of organized mesoporous silica increase in comparison with materials prepared under neutral or acidic conditions. The assembling of particles can be fully separated from their solidification, which results in the formation of highly regular spherical particles of mesoporous silica.

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