Modular Synthesis of Thermosensitive P(NIPAAm-co -HEMA)/β -CD Based Hydrogels via Click Chemistry

2008 ◽  
Vol 30 (3) ◽  
pp. 157-164 ◽  
Author(s):  
Xiao-Ding Xu ◽  
Chang-Sheng Chen ◽  
Bo Lu ◽  
Zong-Chun Wang ◽  
Si-Xue Cheng ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Modular Synthesis

Modular synthesis of glycopolymers with well-defined sugar units in the side chain via Ugi reaction and click chemistry: hetero vs. homo

2016 ◽  
Vol 7 (25) ◽  
pp. 4263-4271 ◽  
Author(s):  
Lulu Xue ◽  
Xinhong Xiong ◽  
Kui Chen ◽  
Yafei Luan ◽  
Gaojian Chen ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Ugi Reaction ◽  
Side Chain ◽  
Click Reactions ◽  
Modular Synthesis

Modularized glycopolymers were prepared via Ugi and click reactions, and used as models to investigate their binding abilities.

Accelerated SuFEx Click Chemistry For Modular Synthesis

2021 ◽  
Author(s):  
Christopher J. Smedley ◽  
Joshua A. Homer ◽  
Timothy L. Gialelis ◽  
Andrew S. Barrow ◽  
Rebecca A. Koelln ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Modular Synthesis

Modular synthesis of photocleavable peptides using click chemistry

2012 ◽  
Vol 53 (15) ◽  
pp. 1933-1935 ◽  
Author(s):  
Joshua A. Baccile ◽  
Mark A. Morrell ◽  
Ross M. Falotico ◽  
Brandon T. Milliken ◽  
Daniel L. Drew ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Modular Synthesis

scholarly journals Modular synthesis of biologically active phosphatidic acid probes using click chemistry

2009 ◽  
Vol 5 (9) ◽  
pp. 962 ◽  
Author(s):  
Matthew D. Smith ◽  
Christopher G. Sudhahar ◽  
Denghuang Gong ◽  
Robert V. Stahelin ◽  
Michael D. Best
Keyword(s):  
Phosphatidic Acid ◽  
Click Chemistry ◽  
Biologically Active ◽  
Modular Synthesis

scholarly journals Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Anlian Zhu ◽  
Xin Li ◽  
Lili Bai ◽  
Gongming Zhu ◽  
Yuanyang Guo ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Click Chemistry ◽  
Binding Affinity ◽  
Nicotinamide Adenine Dinucleotide ◽  
Liquid System ◽  
Molecular Tools ◽  
Adp Ribosylation ◽  
Modular Synthesis ◽  
Protein Partners ◽  
High Binding Affinity

Abstract The α-type ADP-ribosylated peptides represent a class of important molecular tools in the field of protein ADP-ribosylation, however, they are difficult to access because of their inherent complicated structures and the lack of effective synthetic tools. In this paper, we present a biomimetic α-selective ribosylation reaction to synthesize a key intermediate, α-ADP-ribosyl azide, directly from native β-nicotinamide adenine dinucleotide in a clean ionic liquid system. This reaction in tandem with click chemistry then offers a two-step modular synthesis of α-ADP-ribosylated peptides. These syntheses can be performed open air in eppendorf tubes, without the need for specialized instruments or training. Importantly, we demonstrate that the synthesized α-ADP-ribosylated peptides show high binding affinity and desirable stability for enriching protein partners, and reactivity in post-stage poly ADP-ribosylations. Owing to their simple chemistry and multidimensional bio-applications, the presented methods may provide a powerful platform to produce general molecular tools for the study of protein ADP-ribosylation.

Sign in / Sign up

Export Citation Format

Share Document