Force Spectroscopy of Individual Stimulus-Responsive Poly(ferrocenyldimethylsilane) Chains: Towards a Redox-Driven Macromolecular Motor

2006 ◽  
Vol 27 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Shan Zou ◽  
Mark A. Hempenius ◽  
Holger Schönherr ◽  
G. Julius Vancso
Keyword(s):  
Force Spectroscopy ◽  
Individual Stimulus ◽  
Stimulus Responsive

Polypeptide-Solvent Interactions Measured by Single Molecule Force Spectroscopy

2005 ◽  
Vol 898 ◽  
Author(s):  
Alexei Valiaev ◽  
Dong Woo Lim ◽  
Ashutosh Chilkoti ◽  
Scott Schmidler ◽  
Stefan Zauscher
Keyword(s):  
Single Molecule ◽  
Chemical Properties ◽  
Force Spectroscopy ◽  
Hydrophobic Hydration ◽  
Peptide Sequence ◽  
Segment Length ◽  
Single Molecule Force Spectroscopy ◽  
Single Molecule Level ◽  
Solvent Quality ◽  
Stimulus Responsive

AbstractStimulus-responsive biomolecules have attracted a large research interest because of their potential application in various areas such as drug delivery, actuators and sensing devices at the nanoscale. Using single-molecule force spectroscopy (SMFS) we studied elastin-like polypeptides (ELPs). These stimulus-responsive polypeptides undergo an inverse temperature transition, accompanied by a large conformational change, when the solvent quality is changed by increasing the temperature or by addition of salt. Understanding the relationship between peptide sequence and mechanisms of force generation can provide a route to engineer ELPs with desirable mechano-chemical properties. Here we studied the effect of solvent quality and type of guest residue on the mechanical properties of ELPs on the single-molecule level. We used a statistical approach to estimate polymer elasticity parameters from model fits to the data. With this approach we were able to resolve small changes in the Kuhn segment length distributions associated with different molecular architectures. We then show that these mechanical differences likely arise from differences in the hydrophobic hydration of sidegoups, in line with recent predictions from molecular dynamics simulations.

scholarly journals Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 725
Author(s):  
Yuseon Shin ◽  
Patihul Husni ◽  
Kioh Kang ◽  
Dayoon Lee ◽  
Sehwa Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Design ◽  
Solid Tumors ◽  
Tumor Targeting ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Efficacy And Safety ◽  
Stimulus Responsive ◽  
External Signals

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

Dysfunction of endothelial cells exposed to nanomaterials assessed by atomic force spectroscopy

Micron ◽  
2021 ◽  
Vol 145 ◽  
pp. 103062
Author(s):  
Agnieszka Maria Kolodziejczyk ◽  
Paulina Sokolowska ◽  
Aleksandra Zimon ◽  
Magdalena Grala ◽  
Marcin Rosowski ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Force Spectroscopy ◽  
Atomic Force Spectroscopy ◽  
Atomic Force

scholarly journals Single Molecule Force Spectroscopy of Siloxanes

2021 ◽  
Vol 714 (3) ◽  
pp. 032023
Author(s):  
Ling Chen ◽  
Liya Yang ◽  
Chunxia Wang ◽  
Ting Zhu
Keyword(s):  
Single Molecule ◽  
Force Spectroscopy ◽  
Single Molecule Force Spectroscopy

scholarly journals Determination of the molar mass of surface-grafted weak polyelectrolyte brushes using force spectroscopy

Polymer ◽  
2015 ◽  
Vol 67 ◽  
pp. 111-117 ◽  
Author(s):  
Ateyyah AL-Baradi ◽  
Michael R. Tomlinson ◽  
Zhenyu J. Zhang ◽  
Mark Geoghegan
Keyword(s):  
Molar Mass ◽  
Force Spectroscopy ◽  
Polyelectrolyte Brushes
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