Clay Nanotube/Poly(methyl methacrylate) Bone Cement Composites with Sustained Antibiotic Release

2012 ◽  
Vol 297 (7) ◽  
pp. 645-653 ◽  
Author(s):  
Wenbo Wei ◽  
Elshad Abdullayev ◽  
Anne Hollister ◽  
David Mills ◽  
Yuri M. Lvov
Keyword(s):  
Methyl Methacrylate ◽  
Bone Cement ◽  
Cement Composites ◽  
Poly Methyl Methacrylate ◽  
Antibiotic Release

scholarly journals Poly(methyl methacrylate) Bone Cement Composite Can Be Refilled with Antibiotics after Implantation in Femur or Soft Tissue

2021 ◽  
Vol 12 (1) ◽  
pp. 8
Author(s):  
Erika L. Cyphert ◽  
Ningjing Zhang ◽  
Dylan W. Marques ◽  
Greg D. Learn ◽  
Fang Zhang ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Soft Tissue ◽  
Methyl Methacrylate ◽  
Bone Cement ◽  
Muscle Tissue ◽  
Cement Composite ◽  
Poly Methyl Methacrylate ◽  
Intraosseous Infusion ◽  
Pmma Bone Cement ◽  
Antibiotic Release

While periprosthetic joint infections (PJIs) result in a small percentage of patients following arthroplasties, they are challenging to treat if they spread into bone and soft tissue. Treatment involves delivering antibiotics using poly(methyl methacrylate) (PMMA) bone cement. However, antibiotic release is insufficient for prolonged infections. Previous work demonstrated efficacy of incorporating insoluble cyclodextrin (CD) microparticles into PMMA to improve antibiotic release and allow for post-implantation drug refilling to occur in a tissue-mimicking model. To simulate how antibiotic refilling may be possible in more physiologically relevant models, this work investigated development of bone and muscle refilling models. The bone refilling model involved embedding PMMA-CD into rabbit femur and administering antibiotic via intraosseous infusion. Muscle tissue refilling model involved implanting PMMA-CD beads in bovine muscle tissue and administering antibiotic via tissue injection. Duration of antimicrobial activity of refilled PMMA-CD was evaluated. PMMA-CD composite in bone and muscle tissue models was capable of being refilled with antibiotics and resulted in prolonged antimicrobial activity. PMMA-CD provided sustained and on-demand antimicrobial activity without removal of implant if infection develops. Intraosseous infusion appeared to be a viable technique to enable refilling of PMMA-CD after implantation in bone, reporting for the first time the ability to refill PMMA in bone.

scholarly journals Influence of HRGO Nanoplatelets on Behaviour and Processing of PMMA Bone Cement for Surgery

Polymers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2027
Author(s):  
Jaime Orellana ◽  
Ynés Yohana Pastor ◽  
Fernando Calle ◽  
José Ygnacio Pastor
Keyword(s):  
Graphene Oxide ◽  
Methyl Methacrylate ◽  
Bone Cement ◽  
Reduced Graphene Oxide ◽  
Sintering Temperature ◽  
Structural Function ◽  
Mechanical And Thermal Properties ◽  
Poly Methyl Methacrylate ◽  
Pmma Bone Cement ◽  
Reduced Graphene

Bone cement, frequently based on poly (methyl methacrylate), is commonly used in different arthroplasty surgical procedures and its use is essential for prosthesis fixation. However, its manufacturing process reaches high temperatures (up to 120 °C), producing necrosis in the patients' surrounding tissues. To help avoid this problem, the addition of graphene could delay the polymerisation of the methyl methacrylate as it could, simultaneously, favour the optimisation of the composite material's properties. In this work, we address the effect of different percentages of highly reduced graphene oxide with different wt.% (0.10, 0.50, and 1.00) and surface densities (150, 300, 500, and 750 m2/g) on the physical, mechanical, and thermal properties of commercial poly (methyl methacrylate)-based bone cement and its processing. It was noted that a lower sintering temperature was achieved with this addition, making it less harmful to use in surgery and reducing its adverse effects. In contrast, the variation of the density of the materials did not introduce significant changes, which indicates that the addition of highly reduced graphene oxide would not significantly increase bone porosity. Lastly, the mechanical properties (strength, elastic modulus, and fracture toughness) were reduced by almost 20%. Nevertheless, their typical values are high enough that these new materials could still fulfil their structural function. In conclusion, this paper presents a way to control the sintering temperature, without significant degradation of the mechanical performance, by adding highly reduced graphene oxide so that local necrosis of bone cement based on poly (methyl methacrylate) used in surgery is avoided.

scholarly journals Hydroxyapatite Microspheres as an Additive to Enhance Radiopacity, Biocompatibility, and Osteoconductivity of Poly(methyl methacrylate) Bone Cement

Materials ◽  
2018 ◽  
Vol 11 (2) ◽  
pp. 258 ◽  
Author(s):  
In-Gu Kang ◽  
Cheon-Il Park ◽  
Hyun Lee ◽  
Hyoun-Ee Kim ◽  
Sung-Mi Lee
Keyword(s):  
Methyl Methacrylate ◽  
Bone Cement ◽  
Poly Methyl Methacrylate

Osteoconductive Amine-Functionalized Graphene–Poly(methyl methacrylate) Bone Cement Composite with Controlled Exothermic Polymerization

2017 ◽  
Vol 28 (9) ◽  
pp. 2254-2265 ◽  
Author(s):  
Rakesh Sharma ◽  
Govinda Kapusetti ◽  
Sayali Yashwant Bhong ◽  
Partha Roy ◽  
Santosh Kumar Singh ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Bone Cement ◽  
Cement Composite ◽  
Functionalized Graphene ◽  
Poly Methyl Methacrylate ◽  
Amine Functionalized

scholarly journals Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients

2020 ◽  
Vol 7 (1) ◽  
pp. 29-34
Author(s):  
Kefeng Luo ◽  
Guoqiang Jiang ◽  
Jinjin Zhu ◽  
Bin Lu ◽  
Jiye Lu ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Bone Cement ◽  
Vertebral Compression Fractures ◽  
Pure Pmma ◽  
Osteoporotic Vertebral Compression Fractures ◽  
Vertebral Height ◽  
Poly Methyl Methacrylate ◽  
Compression Fractures ◽  
Pmma Bone Cement ◽  
Mineralized Collagen

Abstract To examine the clinical effects of a new bone cement composed of poly(methyl methacrylate) (PMMA) and mineralized collagen (MC) compared with pure PMMA bone cement in treating osteoporotic vertebral compression fractures (OVCFs) in patients aged over 80. In all, 32 cases using pure PMMA bone cement and 31 cases using MC-modified PMMA (MC-PMMA) bone cement for OVCFs between June 2014 and March 2016 were screened as PMMA group and MC-PMMA group, respectively, with an average age of over 80. The operation duration, intraoperative blood loss, hospital stay, oswestry disability index (ODI), visual analogue scale (VAS), anterior vertebral height (AVH), intermediate vertebral height (IVH) and posterior vertebral height (PVH) of injured vertebrae, vertebral computed tomography value, re-fracture rate of adjacent vertebrae, correction rate of spinal kyphotic angle and wedge-shaped vertebra angle and surgical complications were compared between the two groups. In the early post-operative period, the VAS, ODI, AVH and IVH in MC-PMMA group were comparable to those in the traditional PMMA group. Moreover, the MC-PMMA group showed better effects compared with the PMMA group 12 months after surgery. Thus, this new bone cement has superior clinic effects in the long term.

Poly(methyl methacrylate) bone cement, its rise, growth, downfall and future

2020 ◽  
Author(s):  
Sanaz Soleymani Eil Bakhtiari ◽  
Hamid Reza Bakhsheshi‐Rad ◽  
Saeed Karbasi ◽  
Mohamadreza Tavakoli ◽  
Sayed Ali Hassanzadeh Tabrizi ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Bone Cement ◽  
Poly Methyl Methacrylate
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