Oleic Acid Constructed Supramolecular Hyperbranched Polysiloxane with Enhanced Fluorescence and Excellent Drug Delivery Ability

2021 ◽  
pp. 2100283
Author(s):  
Lihua Bai ◽  
Hongxia Yan ◽  
Liulong Guo ◽  
Miaomiao He ◽  
Tian Bai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Enhanced Fluorescence ◽  
Hyperbranched Polysiloxane

A TRANSDERMAL DRUG DELIVERY SYSTEM CONTAINING DEFERIOXAMINE MESYLATE FOR THE TREATMENT OF BETA-THALASSAEMIA MAJOR

2011 ◽  
Vol 23 (01) ◽  
pp. 29-35
Author(s):  
Chin-Hsiung Hsieh ◽  
Yuan-An Ku ◽  
Lien-Hua Chiu ◽  
Tai-Horng Young ◽  
Yi-You Huang
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Iron Overload ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Polysorbate 80 ◽  
Thalassaemia Major ◽  
Pressure Sensitive Adhesives ◽  
Pressure Sensitive

Patients with beta-thalassaemia major need blood transfusion frequently during their whole life. However, frequent transfusions will eventually lead to the accumulation of trivalent iron, resulting in iron overload. To reduce iron overload, patients are administered regularly with intravenous or subcutaneous infusion of deferioxamine mesylate (DFO). Nevertheless, high costs of medication, poor patient compliance, and side effects limit its use and patient's acceptance. To overcome such drawbacks, we developed a novel transdermal delivery system to administer the DFO instead of traditional injections. We assayed the feasibility of fabricating a transdermal DFO patch using the single-layer drug-in-adhesive drug delivery system. We used the pressure-sensitive adhesives and hydrogels as the drug reservoirs and studied the release profile of DFO from the transdermal patches in vitro. In order to enhance the transdermal delivery rate, chemical enhancers, polysorbate 80 and oleic acid, and physical enhancer, ultrasound, were incorporated into the monolith DFO patches. Experimental results showed that the combination of polysorbate 80 and oleic acid in the pressure-sensitive adhesives enhanced the penetration efficiency through nude mice skin. The pretreatment of nude mice skin with ultrasound temporally changed the diffusional resistance and facilitated DFO penetration through the skin. We expect that the new delivery system can enable the drug to penetrate through skin at a stable rate and reach the circulation system successfully, thus allowing the concentration of drug to achieve the therapeutic effect.

Novel Multifunctional Biocompatible Gelatin-Oleic Acid Conjugate: Self-Assembled Nanoparticles for Drug Delivery

2013 ◽  
Vol 9 (8) ◽  
pp. 1416-1431 ◽  
Author(s):  
Phuong Ha-Lien Tran ◽  
Thao Truong-Dinh Tran ◽  
Toi Van Vo ◽  
Chau Le-Ngoc Vo ◽  
Beom-Jin Lee
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Acid Conjugate ◽  
Self Assembled

scholarly journals Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase

Pharmaciana ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 267 ◽  
Author(s):  
Sani Ega Priani ◽  
Nurrayyan Nurrayyan ◽  
Fitrianti Darusman
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Drug Delivery System ◽  
Delivery System

High Fluorescent Hyperbranched Polysiloxane Containing β-Cyclodextrin for Cell Imaging and Drug Delivery

2019 ◽  
Vol 20 (11) ◽  
pp. 4230-4240 ◽  
Author(s):  
Lihua Bai ◽  
Hongxia Yan ◽  
Tian Bai ◽  
Yuanbo Feng ◽  
Yan Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Imaging ◽  
Hyperbranched Polysiloxane

scholarly journals Synthesis and Characterization of New Biocompatible Amino Amphiphilic Compounds Derived from Oleic Acid as Nanovectors for Drug Delivery

Proceedings ◽  
2019 ◽  
Vol 41 (1) ◽  
pp. 1
Author(s):  
Victoria Valdivia ◽  
Chiara Paggiaro ◽  
Inmaculada Fernández
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Aqueous Medium ◽  
Self Assembly ◽  
Tetraethylene Glycol ◽  
Synthetic Approach ◽  
Polar Head ◽  
Amphiphilic Molecules ◽  
Amphiphilic Compounds

Amphiphilic molecules have been actively explored as promising materials in the field of bio and nanotechnology. These molecules are constituted by a polar head and a lipophilic tail and in an aqueous medium are self-assemble to form different types of macromolecular structures such as micelles, monolayer vesicles, bars, sheets and tubes. In this work, a convergent synthetic approach for the synthesis of two new amphiphilic compounds based on a versatile amino polar head, a tetraethylene glycol spacer and a lipophilic tail derived from oleic acid has been developed. Subsequently, after a self-assembly process in aqueous medium, nanostructures as micelles have been obtained and characterized. Finally, a procedure for the inclusion of the highly lipophilic drug Dexamethasone has been carried out in order to study the ability of these micelles to act as nanovectors for drug delivery.

PENGARUH PERBEDAAN CHEMICAL PENETRATION ENHANCER PADA PENETRASI TRANSDERMAL PATCH PROMETAZIN HCL

2017 ◽  
Vol 2 (2) ◽  
pp. 208
Author(s):  
Dwi Nurahmanto
Keyword(s):  
Drug Delivery ◽  
Oleic Acid ◽  
Propylene Glycol ◽  
Transdermal Drug Delivery ◽  
Isopropyl Alcohol ◽  
Oral Absorption ◽  
Penetration Enhancers ◽  
Weight Variation ◽  
Transdermal Drug Delivery Systems

This research aims is to create a promethazine HCl patch transdermal drug delivery systems with the most excellent penetration. Transdermal drug delivery can be efficiently used for the active agents which undergo rapid first pass metabolism and oral absorption is often disrupted by nausea and vomiting, hence the transdermal patches of promethazine HCl were prepared by using different penetration enhancers,  propylene glycol, oleic acid and isopropyl alcohol. The prepared formulations were evaluated for thickness, weight variation, moisture content, drug content, morphology, and in vitro permeation studies. The patch morphology studies were performed by Scanning Electron Microscopy (SEM). The amount of promethazine HCl transfered by propylene glycol  25.77 ± 3.0396 ug, isopropil alcohol 25.758 ± 2.9022 ug and oleic acid 25.017 ± 8.1300 ug. The penetration of promethazine HCl patch with oleic acid enhancer, produce the highest penetration than isopropil alcohol and propylene glycol. there was no difference in penetration using propylene glycol and isopropyl alcohol. Oleic acid is the best enhancer for preparations patch containing promethazine HCl although the amount of promethazine HCl contained is the least. The whole formulations comply with the  patch dosage requirements

Synthesis of Gold Nanoflowers Encapsulated with Poly(N-isopropylacrylamide-co-acrylic acid) Hydrogels

2015 ◽  
Vol 15 (10) ◽  
pp. 7962-7965 ◽  
Author(s):  
Saet-Byeol Bae ◽  
Sang-Wh Lee
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Ascorbic Acid ◽  
Oleic Acid ◽  
Polymerization Reaction ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Monomer Ratio ◽  
Carboxylate Groups ◽  
Gold Nanoflowers

In this work, hydrogel-coated gold nanoflowers (AuNFs@hydrogel) were facilely prepared. First, gold nanoflowers (AuNFs) were synthesized by reducing gold acid with ascorbic acid in the presence of chitosan biopolymers, and the chitosan-mediated AuNFs were subsequently conjugated with oleic acid with carboxylate groups. Finally, the olefin-conjugated AuNFs were encapsulated with P(NIPAM-co-AAC) hydrogels via a radical polymerization reaction with co-monomer ratio of [NIPAM:AAc = 91:9 wt%]. The encapsulated hydrogels had a lower critical solution temperature (LCST) slightly above the physiological temperature and demonstrated a thermo-sensitive variation of particle size. The hydrogel-coated AuNFs can be utilized as a promising thermo-responsive drug delivery system with a unique optical property. As-prepared samples were characterized by DLS, SEM, TEM, UV-vis and Zeta potential meter.

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