scholarly journals Hydrophilic (AB) n Segmented Copolymers for Melt Extrusion‐Based Additive Manufacturing

2020 ◽  
pp. 2000265
Author(s):  
Jannik Mechau ◽  
Andreas Frank ◽  
Ezgi Bakirci ◽  
Simon Gumbel ◽  
Tomasz Jungst ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Melt Extrusion ◽  
Segmented Copolymers

scholarly journals Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion

2017 ◽  
Vol 33 (2) ◽  
pp. 198-208 ◽  
Author(s):  
Casper Slots ◽  
Martin Bonde Jensen ◽  
Nicholas Ditzel ◽  
Martin A.B. Hedegaard ◽  
Søren Wiatr Borg ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Melt Extrusion

scholarly journals Melt‐Extrusion‐Based Additive Manufacturing of Transparent Fused Silica Glass (Adv. Sci. 23/2021)

2021 ◽  
Vol 8 (23) ◽  
pp. 2170159
Author(s):  
Markus Mader ◽  
Leonhard Hambitzer ◽  
Phillip Schlautmann ◽  
Sophie Jenne ◽  
Christian Greiner ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Silica Glass ◽  
Fused Silica ◽  
Melt Extrusion ◽  
Fused Silica Glass

Quadruple Hydrogen Bonding Supramolecular Elastomers for Melt Extrusion Additive Manufacturing

2020 ◽  
Vol 12 (28) ◽  
pp. 32006-32016 ◽  
Author(s):  
Xi Chen ◽  
Callie E. Zawaski ◽  
Glenn A. Spiering ◽  
Boer Liu ◽  
Christina M. Orsino ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Additive Manufacturing ◽  
Melt Extrusion ◽  
Quadruple Hydrogen Bonding

Processability of poly(vinyl alcohol) Based Filaments With Paracetamol Prepared by Hot-Melt Extrusion for Additive Manufacturing

2020 ◽  
Vol 109 (12) ◽  
pp. 3636-3644
Author(s):  
Joana Macedo ◽  
Aseel Samaro ◽  
Valérie Vanhoorne ◽  
Chris Vervaet ◽  
João F. Pinto
Keyword(s):  
Additive Manufacturing ◽  
Vinyl Alcohol ◽  
Hot Melt Extrusion ◽  
Poly Vinyl Alcohol ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals Coupling Additive Manufacturing with Hot Melt Extrusion Technologies to Validate a Ventilator-Associated Pneumonia Mouse Model

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 772
Author(s):  
Bahaa Shaqour ◽  
Juliana Aizawa ◽  
Clara Guarch-Pérez ◽  
Żaneta Górecka ◽  
Lars Christophersen ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Thermoplastic Polyurethane ◽  
Hot Melt Extrusion ◽  
Polymeric Matrix ◽  
Ventilator Associated Pneumonia ◽  
Melt Extrusion ◽  
Good Thermal Stability ◽  
Hot Melt

Additive manufacturing is widely used to produce highly complex structures. Moreover, this technology has proven its superiority in producing tools which can be used in different applications. We designed and produced an extrusion nozzle that allowed us to hot melt extrude drug-loaded tubes. The tubes were an essential part of a new mouse ventilator-associated pneumonia (VAP) model. Ciprofloxacin (CPX) was selected for its expected activity against the pathogen Staphylococcus aureus and ease of incorporation into thermoplastic polyurethane (TPU). TPU was selected as the carrier polymer for its biocompatibility and use in a variety of medical devices such as tubing and catheters. The effect of loading CPX within the TPU polymeric matrix and the physicochemical properties of the produced tubes were investigated. CPX showed good thermal stability and in vitro activity in preventing S. aureus biofilm formation after loading within the tube’s polymeric matrix. Moreover, the produced tubes showed anti-infective efficacy in vivo. The produced tubes, which were extruded via our novel nozzle, were vital for the validation of our mouse VAP model. This model can be adopted to investigate other antibacterial and antibiofilm compounds incorporated in polymeric tubes using hot melt extrusion.

scholarly journals Effect of Highly Loaded Nanohydroxyapatite Composite Scaffolds Prepared via Melt Extrusion Additive Manufacturing on the Osteogenic Differentiation of Human Mesenchymal Stromal Cells

2021 ◽  
Author(s):  
María Cámara-Torres ◽  
Ravi Sinha ◽  
Alberto Sanchez ◽  
Pamela Habibovic ◽  
Alessandro Patelli ◽  
...  
Keyword(s):  
Additive Manufacturing ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Matrix Composition ◽  
Osteogenic Potential ◽  
Great Promise ◽  
Melt Extrusion ◽  
Human Mesenchymal Stromal Cells ◽  
Highly Loaded

AbstractThe field of bone tissue engineering seeks to mimic the bone extracellular matrix composition, balancing the organic and inorganic components. In this regard, additive manufacturing (AM) of highly loaded polymer-calcium phosphate (CaP) composites holds great promise towards the design of bioactive scaffolds. Yet, the biological performance of such scaffolds is still poorly characterized. In this study, melt extrusion AM (ME-AM) was used to fabricate poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT)-nanohydroxyapatite (nHA) scaffolds with up to 45 wt% nHA, which presented significantly enhanced compressive mechanical properties, to evaluate their in vitro osteogenic potential as a function of nHA content. While osteogenic gene upregulation and matrix mineralization were observed on all scaffold types when cultured in osteogenic media, human mesenchymal stromal cells did not present an explicitly clear osteogenic phenotype, within the evaluated timeframe, in basic media cultures (i.e. without osteogenic factors). Yet, due to the adsorption of calcium and inorganic phosphate ions from cell culture media and simulated body fluid, the formation of a CaP layer was observed on PEOT/PBT-nHA 45 wt% scaffolds, which is hypothesized to account for their osteoinductivity in the long term in vitro, and osteoconductivity in vivo.

A review of melt extrusion additive manufacturing processes: I. Process design and modeling

2014 ◽  
Vol 20 (3) ◽  
pp. 192-204 ◽  
Author(s):  
Brian N. Turner ◽  
Robert Strong ◽  
Scott A. Gold
Keyword(s):  
Systematic Review ◽  
Additive Manufacturing ◽  
Rapid Prototyping ◽  
Process Design ◽  
Fused Deposition Modeling ◽  
Process Models ◽  
Melt Extrusion ◽  
Content Type ◽  
Fused Deposition ◽  
Deposition Modeling

Purpose – The purpose of this paper is to systematically and critically review the literature related to process design and modeling of fused deposition modeling (FDM) and similar extrusion-based additive manufacturing (AM) or rapid prototyping processes. Design/methodology/approach – A systematic review of the literature focusing on process design and mathematical process modeling was carried out. Findings – FDM and similar processes are among the most widely used rapid prototyping processes with growing application in finished part manufacturing. Key elements of the typical processes, including the material feed mechanism, liquefier and print nozzle; the build surface and environment; and approaches to part finishing are described. Approaches to estimating the motor torque and power required to achieve a desired filament feed rate are presented. Models of required heat flux, shear on the melt and pressure drop in the liquefier are reviewed. On leaving the print nozzle, die swelling and bead cooling are considered. Approaches to modeling the spread of a deposited road of material and the bonding of polymer roads to one another are also reviewed. Originality/value – To date, no other systematic review of process design and modeling research related to melt extrusion AM has been published. Understanding and improving process models will be key to improving system process controls, as well as enabling the development of advanced engineering material feedstocks for FDM processes.

Additive Manufacturing of Poly(propylene) by Means of Melt Extrusion

2016 ◽  
Vol 301 (12) ◽  
pp. 1482-1493 ◽  
Author(s):  
Sebastian Hertle ◽  
Maximilian Drexler ◽  
Dietmar Drummer
Keyword(s):  
Additive Manufacturing ◽  
Melt Extrusion ◽  
Poly Propylene
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