Covalent Chitosan‐Cellulose Hydrogels via Schiff‐Base Reaction Containing Macromolecular Microgels for pH‐Sensitive Drug Delivery and Wound Dressing

2019 ◽  
Vol 220 (23) ◽  
pp. 1900399 ◽  
Author(s):  
Shoukang Du ◽  
Xiaojin Chen ◽  
Xiaofei Chen ◽  
Shengke Li ◽  
Guoliang Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Wound Dressing ◽  
Ph Sensitive

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

Preparation of PH-sensitive drug delivery nanoparticles (PEG-Schiff base-Doxorubicin)

2020 ◽  
Vol 1 (1) ◽  
pp. 127-134
Author(s):  
Jiabo Lan ◽  
Junru Shen ◽  
Linjie Dai ◽  
Tangxuan Wen ◽  
Xiaoheng Zou
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Ph Sensitive

pH-sensitive polymers for drug delivery

2012 ◽  
Vol 20 (3) ◽  
pp. 224-233 ◽  
Author(s):  
Kang Moo Huh ◽  
Han Chang Kang ◽  
Young Ju Lee ◽  
You Han Bae
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive

scholarly journals Recent Progress in Polysaccharide Aerogels: Their Synthesis, Application, and Future Outlook

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1347
Author(s):  
Arbanah Muhammad ◽  
Dabin Lee ◽  
Yonghun Shin ◽  
Juhyun Park
Keyword(s):  
Drug Delivery ◽  
Supercritical Co2 ◽  
Wound Dressing ◽  
Freeze Drying ◽  
Recent Progress ◽  
Present Review ◽  
Porous Structures ◽  
Air Filtration ◽  
Future Outlook ◽  
Synthetic Process

Porous polysaccharides have recently attracted attention due to their porosity, abundance, and excellent properties such as sustainability and biocompatibility, thereby resulting in their numerous applications. Recent years have seen a rise in the number of studies on the utilization of polysaccharides such as cellulose, chitosan, chitin, and starch as aerogels due to their unique performance for the fabrication of porous structures. The present review explores recent progress in porous polysaccharides, particularly cellulose and chitosan, including their synthesis, application, and future outlook. Since the synthetic process is an important aspect of aerogel formation, particularly during the drying step, the process is reviewed in some detail, and a comparison is drawn between the supercritical CO2 and freeze drying processes in order to understand the aerogel formation of porous polysaccharides. Finally, the current applications of polysaccharide aerogels in drug delivery, wastewater, wound dressing, and air filtration are explored, and the limitations and outlook of the porous aerogels are discussed with respect to their future commercialization.

Synthesis of Poly(ε-caprolactone) Diacrylate for Micelle-Cross-Linked Sodium AMPS Hydrogel for Use as Controlled Drug Delivery Wound Dressing

2021 ◽  
Author(s):  
Amlika Rungrod ◽  
Apichaya Kapanya ◽  
Winita Punyodom ◽  
Robert Molloy ◽  
Jomkhwan Meerak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Dressing ◽  
Controlled Drug Delivery

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading

pH-sensitive polyion complex micelles for tunable intracellular drug delivery

2015 ◽  
Vol 213 ◽  
pp. e55
Author(s):  
Jinjin Chen ◽  
Ying Zhang ◽  
Jianxun Ding ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Intracellular Drug Delivery ◽  
Complex Micelles

К‐carrageenan/Na‐alginate wound dressing with sustainable drug delivery properties

2021 ◽  
Author(s):  
Hesham M. Fahmy ◽  
Amal A. Aly ◽  
Shymaa M. Sayed ◽  
Ashraf Abou‐Okeil
Keyword(s):  
Drug Delivery ◽  
Wound Dressing
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