Size-Dependent Self-Assembly of Anisotropic Silica-Coated Hybrid Nanoparticles

2015 ◽  
Vol 216 (21) ◽  
pp. 2070-2079 ◽  
Author(s):  
Diego Estupiñán ◽  
Markus B. Bannwarth ◽  
Katharina Landfester ◽  
Daniel Crespy
Keyword(s):  
Self Assembly ◽  
Hybrid Nanoparticles ◽  
Size Dependent

scholarly journals Dual Targeting of Cancer Cells and MMPs with Self-Assembly Hybrid Nanoparticles for Combination Therapy in Combating Cancer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 1990
Author(s):  
Kai Zhang ◽  
Jingjing Li ◽  
Xiaofei Xin ◽  
Xiaoqing Du ◽  
Di Zhao ◽  
...  
Keyword(s):  
T Cells ◽  
Cancer Cells ◽  
Self Assembly ◽  
Chemotherapeutic Agents ◽  
Hybrid Nanoparticles ◽  
Control Group ◽  
Hyperthermia Treatment ◽  
Immune Modulators ◽  
Dual Targeting

The co-delivery of chemotherapeutic agents and immune modulators to their targets remains to be a great challenge for nanocarriers. Here, we developed a hybrid thermosensitive nanoparticle (TMNP) which could co-deliver paclitaxel-loaded transferrin (PTX@TF) and marimastat-loaded thermosensitive liposomes (MMST/LTSLs) for the dual targeting of cancer cells and the microenvironment. TMNPs could rapidly release the two payloads triggered by the hyperthermia treatment at the site of tumor. The released PTX@TF entered cancer cells via transferrin-receptor-mediated endocytosis and inhibited the survival of tumor cells. MMST was intelligently employed as an immunomodulator to improve immunotherapy by inhibiting matrix metalloproteinases to reduce chemokine degradation and recruit T cells. The TMNPs promoted the tumor infiltration of CD3+ T cells by 2-fold, including memory/effector CD8+ T cells (4.2-fold) and CD4+ (1.7-fold), but not regulatory T cells. Our in vivo anti-tumor experiment suggested that TMNPs possessed the highest tumor growth inhibitory rate (80.86%) compared with the control group. We demonstrated that the nanoplatform could effectively inhibit the growth of tumors and enhance T cell recruitment through the co-delivery of paclitaxel and marimastat, which could be a promising strategy for the combination of chemotherapy and immunotherapy for cancer treatment.

Size-Dependent Separation of Colloidal Particles In Two-Dimensional Convective Self-Assembly

Langmuir ◽  
1995 ◽  
Vol 11 (8) ◽  
pp. 2975-2978 ◽  
Author(s):  
Mariko Yamaki ◽  
Junichi Higo ◽  
Kuniaki Nagayama
Keyword(s):  
Self Assembly ◽  
Colloidal Particles ◽  
Two Dimensional ◽  
Size Dependent

Paclitaxel-induced formation of 3D nanocrystal superlattices within injectable protein-based hybrid nanoparticles

2018 ◽  
Vol 54 (82) ◽  
pp. 11586-11589
Author(s):  
Jeong Yu Lee ◽  
Ho Yeon Son ◽  
Jae Chul Park ◽  
Jongnam Park ◽  
Yoon Sung Nam
Keyword(s):  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Self Assembly ◽  
Three Dimensional ◽  
Superparamagnetic Iron Oxide ◽  
Hybrid Nanoparticles ◽  
Nanocrystal Superlattices

Self-assembly of monodisperse superparamagnetic iron oxide nanocrystals into a close-packed, three-dimensional (3D) superlattice is designed within cross-linked protein-based nanoparticles composed of human serum albumin and polyethylene glycol.

scholarly journals Size-dependent thermodynamic structural selection in colloidal crystallization

2019 ◽  
Vol 5 (9) ◽  
pp. eaaw5912 ◽  
Author(s):  
Evan Pretti ◽  
Hasan Zerze ◽  
Minseok Song ◽  
Yajun Ding ◽  
Runfang Mao ◽  
...  
Keyword(s):  
Self Assembly ◽  
Colloidal Particles ◽  
Size Dependence ◽  
Fluid Phase ◽  
Two Dimensions ◽  
Size Dependent ◽  
Colloidal Crystallization ◽  
Kinetic Effects ◽  
Physical Phenomena ◽  
Surrounding Fluid

Nucleation and growth of crystalline phases play an important role in a variety of physical phenomena, ranging from freezing of liquids to assembly of colloidal particles. Understanding these processes in the context of colloidal crystallization is of great importance for predicting and controlling the structures produced. In many systems, crystallites that nucleate have structures differing from those expected from bulk equilibrium thermodynamic considerations, and this is often attributed to kinetic effects. In this work, we consider the self-assembly of a binary mixture of colloids in two dimensions, which exhibits a structural transformation from a non–close-packed to a close-packed lattice during crystal growth. We show that this transformation is thermodynamically driven, resulting from size dependence of the relative free energy between the two structures. We demonstrate that structural selection can be entirely thermodynamic, in contrast to previously considered effects involving growth kinetics or interaction with the surrounding fluid phase.

Synthesis of Self-Assembly Au Nano-Particles Based on Sodium Citrate-Tannin Reduction Method

2011 ◽  
Vol 311-313 ◽  
pp. 461-465
Author(s):  
Dau Chung Wang ◽  
Shinn Hwa Chen ◽  
Gen You Chen ◽  
Ken Yen Chen ◽  
Cheng Hsien Tsai
Keyword(s):  
Particle Size ◽  
Self Assembly ◽  
Reduction Method ◽  
Low Cost ◽  
Trisodium Citrate ◽  
Nano Particles ◽  
Size Dependent ◽  
Biological Toxicity ◽  
The One ◽  
Au Nano Particles

Recently, self-assembly synthesis of metal nano-particles has attracted great interest due to its unique size dependent properties. In this study, an easy synthesis would be developed to form Au nano-particles which are without toxicity. The Au particles could be applied in biological and biological toxicity experiments. Some phenomena could be discovered in this paper. First, the concentration ratio of Au and trisodium citrate would be adjusted to control the Au nano-particles size. And the particle size is limited because of the size dependent energy would be discovered in this paper. The minimum particle size is also found. The one phase liquid reduction method is easy and without toxicity, it is low-cost, high-throughput, and suitable to be applied in biological and biological toxicity studies.

scholarly journals Size-dependent self-assembly of submicron/nano beads–protein conjugates for construction of a protein nanoarray

2009 ◽  
Vol 29 (8) ◽  
pp. 2459-2463 ◽  
Author(s):  
Tremaine B. Powell ◽  
Phat L. Tran ◽  
Keesung Kim ◽  
Jeong-Yeol Yoon
Keyword(s):  
Self Assembly ◽  
Protein Conjugates ◽  
Size Dependent

scholarly journals Self-assembly and plasmon-enhanced ultrafast magnetization of Ag–Co hybrid nanoparticles

2014 ◽  
Vol 4 (8) ◽  
pp. 1564 ◽  
Author(s):  
Katsura Ikemiya ◽  
Kuniaki Konishi ◽  
Eiko Fujii ◽  
Toshihiro Kogure ◽  
Makoto Kuwata-Gonokami ◽  
...  
Keyword(s):  
Self Assembly ◽  
Hybrid Nanoparticles ◽  
Ultrafast Magnetization

Polymer-inorganic hybrid nanoparticles of various morphologies via polymerization-induced self assembly and sol–gel chemistry

2016 ◽  
Vol 7 (43) ◽  
pp. 6575-6585 ◽  
Author(s):  
Guo Hui Teo ◽  
Rhiannon P. Kuchel ◽  
Per B. Zetterlund ◽  
Stuart C. Thickett
Keyword(s):  
Self Assembly ◽  
Sol Gel ◽  
Hybrid Nanoparticles ◽  
Inorganic Hybrid ◽  
Silica Hybrid

The preparation of polymer-silica hybrid nanoparticles of various morphologies is reported.

Biphasic Self-Assembly Pathways and Size-Dependent Photophysical Properties of Perylene Bisimide Dye Aggregates

2013 ◽  
Vol 135 (50) ◽  
pp. 18722-18725 ◽  
Author(s):  
Franziska Fennel ◽  
Steffen Wolter ◽  
Zengqi Xie ◽  
Per-Arno Plötz ◽  
Oliver Kühn ◽  
...  
Keyword(s):  
Self Assembly ◽  
Photophysical Properties ◽  
Perylene Bisimide ◽  
Size Dependent ◽  
Assembly Pathways
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