Novel Poly(vinyl alcohol)/Chitosan/Modified Graphene Oxide Biocomposite for Wound Dressing Application

2020 ◽  
Vol 20 (3) ◽  
pp. 1900385 ◽  
Author(s):  
Siyao Chen ◽  
He Wang ◽  
Zhiwen Jian ◽  
Guoxia Fei ◽  
Wei Qian ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Poly Vinyl Alcohol ◽  
Modified Graphene Oxide ◽  
Modified Graphene

Surface modified graphene oxide/poly(vinyl alcohol) composite for enhanced hydrogen gas barrier film

2016 ◽  
Vol 50 ◽  
pp. 49-56 ◽  
Author(s):  
Hongyu Liu ◽  
Parthasarathi Bandyopadhyay ◽  
Nam Hoon Kim ◽  
Bongho Moon ◽  
Joong Hee Lee
Keyword(s):  
Graphene Oxide ◽  
Vinyl Alcohol ◽  
Hydrogen Gas ◽  
Poly Vinyl Alcohol ◽  
Gas Barrier ◽  
Modified Graphene Oxide ◽  
Surface Modified ◽  
Modified Graphene ◽  
Barrier Film

Biocompatible electrospinning poly(vinyl alcohol) nanofibres embedded with graphene-based derivatives with enhanced conductivity, mechanical strength and thermal stability

RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56373-56384 ◽  
Author(s):  
Yuan-Hsiang Yu ◽  
Chih-Chieh Chan ◽  
Yu-Chia Lai ◽  
Yan-Yu Lin ◽  
Ying-Chieh Huang ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Graphene Oxide ◽  
Mechanical Strength ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Modified Graphene Oxide ◽  
Electrospun Nanofibres ◽  
Modified Graphene ◽  
Enhanced Conductivity

Biocompatible poly(vinyl alcohol) nanocomposite electrospun nanofibres embedded with glycine-modified graphene oxide and nanogold-deposited graphene oxide with substantially enhanced conductivity, mechanical strength, and thermal stability.

Polyurethane-modified graphene oxide composite bilayer wound dressing with long-lasting antibacterial effect

2020 ◽  
Vol 111 ◽  
pp. 110833 ◽  
Author(s):  
Zhiwen Jian ◽  
He Wang ◽  
Menglong Liu ◽  
Siyao Chen ◽  
Zhanhua Wang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Wound Dressing ◽  
Antibacterial Effect ◽  
Oxide Composite ◽  
Modified Graphene Oxide ◽  
Modified Graphene

scholarly journals Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded dopmine-modified graphene oxide

2021 ◽  
Author(s):  
Chuan Fu ◽  
Zhiping Qi ◽  
Chengliang Zhao ◽  
Wenlai Kong ◽  
Hongru Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Antimicrobial Peptides ◽  
Wound Dressing ◽  
Skin Wound ◽  
Nanocomposite Membrane ◽  
Modified Graphene Oxide ◽  
Repair Ability ◽  
Modified Graphene ◽  
Dressing Materials

Abstract Skin wound healing is a complicated and lengthy process, which is influenced by multiple factors and need a suitable cellular micro-environment. For skin wound, wound dressings remain a cornerstone of dermatologic therapy at present. The dressing material can create an effective protective environment for the wound, and the interactions between the dressing and the wound has a great impact on the wound healing efficiency. An ideal wound dressing materials should have good biocompatibility, moisturizing property, antibacterial property and mechanical strength, and can effectively prevent wound infection and promote wound healing. In this study, in order to design wound dressing materials endowed with excellent antibacterial and tissue repair properties, we attempted to load antimicrobial peptides onto dopmine-modified graphene oxide (PDA@GO) using lysozyme (ly) as a model drug. Then, functionalized GO was used to the surface modification of arginine-modified chitosan (CS-Arg) membrane. To evaluate the potential of the prepared nanocomposite membrane in wound dressing application, the surface morphology, hydrophilic, mechanical properties, antimicrobial activity, and cytocompatibility of the resulting nanocomposite membrane were analyzed. The results revealed that prepared nanocomposite membrane exhibited excellent hydrophilic, mechanical strength and antimicrobial activity, which can effectively promote cell growth and adhesion. In particular, using PDA@GO as drug carrier can effectively maintain the activity of antimicrobial peptides, and can maximize the antibacterial properties of the nanocomposite membrane. Finally, we used rat full-thickness wound models to observe wound healing, and the surface interactions between the prepared nanocomposite membrane and the wound. The results indicates that nanocomposite membrane can obviouly accelerated wound closure, and the wounds showed reduced inflammation, improved angiogenesis and accelerated re-epithelialization. Therefore, incorporation of antimicrobial peptides -functionalize graphene oxide (ly-PDA@GO) into CS-Arg membrane was a viable strategy for fabricating excellent wound dressing. Together, this study not only prepared a wound dressing with excellent tissue repair ability, but also provided a novel idea for the development of graphene oxide-based antibacterial dressing.

scholarly journals Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded polydopamine-modified graphene oxide

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Chuan Fu ◽  
Zhiping Qi ◽  
Chengliang Zhao ◽  
Weijian Kong ◽  
Hongru Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Antimicrobial Peptides ◽  
Wound Dressing ◽  
Skin Wound ◽  
Nanocomposite Membrane ◽  
Modified Graphene Oxide ◽  
Repair Ability ◽  
Modified Graphene ◽  
Dressing Materials

AbstractSkin wound healing is a complicated and lengthy process, which is influenced by multiple factors and need a suitable cellular micro-environment. For skin wound, wound dressings remain a cornerstone of dermatologic therapy at present. The dressing material can create an effective protective environment for the wound, and the interactions between the dressing and the wound has a great impact on the wound healing efficiency. An ideal wound dressing materials should have good biocompatibility, moisturizing property, antibacterial property and mechanical strength, and can effectively prevent wound infection and promote wound healing. In this study, in order to design wound dressing materials endowed with excellent antibacterial and tissue repair properties, we attempted to load antimicrobial peptides onto dopmine-modified graphene oxide (PDA@GO) using lysozyme (ly) as a model drug. Then, functionalized GO was used to the surface modification of arginine-modified chitosan (CS-Arg) membrane. To evaluate the potential of the prepared nanocomposite membrane in wound dressing application, the surface morphology, hydrophilic, mechanical properties, antimicrobial activity, and cytocompatibility of the resulting nanocomposite membrane were analyzed. The results revealed that prepared nanocomposite membrane exhibited excellent hydrophilic, mechanical strength and antimicrobial activity, which can effectively promote cell growth and adhesion. In particular, using PDA@GO as drug carrier can effectively maintain the activity of antimicrobial peptides, and can maximize the antibacterial properties of the nanocomposite membrane. Finally, we used rat full-thickness wound models to observe wound healing, and the surface interactions between the prepared nanocomposite membrane and the wound. The results indicated that nanocomposite membrane can obviously accelerated wound closure, and the wounds showed reduced inflammation, improved angiogenesis and accelerated re-epithelialization. Therefore, incorporation of antimicrobial peptides-functionalize graphene oxide (ly-PDA@GO) into CS-Arg membrane was a viable strategy for fabricating excellent wound dressing. Together, this study not only prepared a wound dressing with excellent tissue repair ability, but also provided a novel idea for the development of graphene oxide-based antibacterial dressing.

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