Identification of a Glypican-3-Binding Peptide for In Vivo Non-Invasive Human Hepatocellular Carcinoma Detection

2016 ◽  
Vol 17 (4) ◽  
pp. 1600335 ◽  
Author(s):  
Zainen Qin ◽  
Jingjing Wang ◽  
Ye Wang ◽  
Guohao Wang ◽  
Xiangyu Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma ◽  
Binding Peptide ◽  
Non Invasive

Radiolabelled monoclonal antibodies against alpha-fetoprotein for in vivo localization of human hepatocellular carcinoma by immunotomoscintigraphy

1987 ◽  
Vol 13 (8) ◽  
pp. 385-390 ◽  
Author(s):  
Jean-Fran�ois Bergmann ◽  
Jean-Denis Lumbroso ◽  
Luc Manil ◽  
Jean-Claude Saccavini ◽  
Philippe Rougier ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Monoclonal Antibodies ◽  
Alpha Fetoprotein ◽  
Human Hepatocellular Carcinoma ◽  
Radiolabelled Monoclonal Antibodies

scholarly journals Accumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yang Yang ◽  
Qi Mei
Keyword(s):  
Hepatocellular Carcinoma ◽  
Small Rna ◽  
Human Hepatocellular Carcinoma ◽  
Cell Behaviors ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Different Types ◽  
Cell Cycle Inhibition ◽  
Xenograft Mice

AGO2 (Argonaute RISC Catalytic Component 2) plays an important role in small RNA-guided gene silencing processes. It has been implied in tumorigenesis of different types of tumors. In this study, we found that AGO2 expression was remarkably increased in human hepatocellular carcinoma (HCC) tissues when compared with adjacent noncancerous tissues. High expression of AGO2 was associated with poor prognosis in HCC patients. The CRISPR/Cas9-mediated knockout of AGO2 in SMMC-7721 cells inhibited cell proliferation and induced significant G1 phase arrest of cell cycle. Inhibition of cell migration was also observed in SMMC-7721 AGO2-/- cells. In vivo experiments showed that tumors grew slower in nude mice transplanted with AGO2-/- cells than in SMMC-7721 cell-derived xenograft mice. Microarray analysis and western blot analysis revealed that AGO2 depletion decreased expression of Survivin, Vimentin, and Snail. Overexpression of AGO2 in SMMC-7721 and Huh-7 cells could reverse the knockout-induced inhibition effects on either cell behaviors or expression of Survivin, Vimentin, and Snail Therefore, our data demonstrated that AGO2 might facilitate HCC tumorigenesis and metastasis through modulating expression of Survivin, Vimentin, and Snail.

510 Inhibition of cyclooxygenase-2 suppresses the growth of human hepatocellular carcinoma implants in vivo

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 405-405
Author(s):  
M KERN ◽  
M SCHONEWEISS ◽  
D SAHI ◽  
M BAHLO ◽  
A HAUGG ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cyclooxygenase 2 ◽  
Human Hepatocellular Carcinoma

Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo

2009 ◽  
Vol 286 (2) ◽  
pp. 223-231 ◽  
Author(s):  
Zhang Zhang ◽  
Shuo Wang ◽  
Hong Qiu ◽  
Chaohui Duan ◽  
Kan Ding ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Human Hepatocellular Carcinoma ◽  
Hepatocellular Carcinoma Cells ◽  
Human Hepatocellular Carcinoma Cells

In vivo imaging of hepatocellular carcinoma using a glypican-3-binding peptide based probe

2017 ◽  
Author(s):  
Qi Zhang ◽  
Zhihao Han ◽  
Wancun Zhang ◽  
Zhiyu Qian ◽  
Yueqing Gu
Keyword(s):  
Hepatocellular Carcinoma ◽  
In Vivo Imaging ◽  
Binding Peptide

scholarly journals BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma

Oncogene ◽  
2007 ◽  
Vol 27 (9) ◽  
pp. 1208-1217 ◽  
Author(s):  
B C-L Chan ◽  
A K-K Ching ◽  
K-F To ◽  
J C-K Leung ◽  
S Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma ◽  
Antiapoptotic Protein
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