A Smart Drug Delivery System from Charge-Conversion Polymer-Drug Conjugate for Enhancing Tumor Therapy and Tunable Drug Release

2014 ◽  
Vol 14 (4) ◽  
pp. 485-490 ◽  
Author(s):  
Hailong Huang ◽  
Yapeng Li ◽  
Zongpeng Sa ◽  
Yuan Sun ◽  
Yuzhen Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Therapy ◽  
Drug Conjugate ◽  
Smart Drug ◽  
Smart Drug Delivery

Novel Thioacetal-Bridged Hollow Mesoporous Organosilica Nanoparticles with ROS-Responsive Biodegradability for Smart Drug Delivery

NANO ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. 1950141 ◽  
Author(s):  
Zeyang Lin ◽  
Long Xu ◽  
Jianfeng Zhang ◽  
Zhou Li ◽  
Jinshun Zhao
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Drug Release ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Organosilica ◽  
Smart Drug ◽  
Smart Drug Delivery

Intelligent, efficient silica nanoparticles for drug delivery system in cancer therapy have a great application potential, but the biodegradability of silica nanoparticles becomes an intractable hindrance. In this work, novel reactive oxygen species (ROS)-responsive hollow mesoporous organosilica nanoparticles (HMONs) coated with polydopamine (PDA) biofilm and amino-terminated methoxy poly(ethylene glycol) (mPEG-NH[Formula: see text] were synthesized and applied in the smart drug delivery system (HMONs@PDA-mPEG) for the delivery of doxorubicin (DOX). The nanostructures and morphologies of nanoparticles were characterized by Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), N2 adsorption/desorption, dynamic light scattering (DLS) and thermogravimetric analysis. Based on the “chemical homology” mechanism, physiologically active thioacetal-bridged silsesquioxane was molecularly incorporated into the framework of silica nanoparticles to form ROS-responsive HMONs, which was verified by the in vitro degradation experiment. The in vitro drug release profiles showed a synergistically pH-dependent and ROS-responsive drug release effect. MTT assay toward A549 cells demonstrated that drug carriers had a biocompatibility, and DOX-loaded nanoparticles (DNs) presented a concentration-dependent and time-dependent cell growth inhibition effect. In summary, the novel ROS-responsive HMONs@PDA-mPEG had a promising application as a smart drug delivery system in biomedical field.

Diatom mediated smart drug delivery system

2021 ◽  
Vol 63 ◽  
pp. 102433
Author(s):  
Sakshi Phogat ◽  
Abhishek Saxena ◽  
Neha Kapoor ◽  
Charu Aggarwal ◽  
Archana Tiwari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Erratum: Corrigendum: Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Peipei Xu ◽  
Huaqin Zuo ◽  
Bing Chen ◽  
Ruju Wang ◽  
Arsalan Ahmed ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

Glucose-Responsive Microspheres as a Smart Drug Delivery System for Controlled Release of Insulin

2019 ◽  
Vol 45 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Jiaojiao Yu ◽  
Qiongyan Wang ◽  
Haofan Liu ◽  
Xiaosong Shan ◽  
Ziyan Pang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals DENDRITIC POLY(L-GLUTAMIC ACID) BASED SMART DRUG DELIVERY SYSTEM

2011 ◽  
Vol 011 (8) ◽  
pp. 845-852
Author(s):  
Chao JIANG ◽  
Mingming SHENG ◽  
Bin HE ◽  
Gang WANG ◽  
Yao WU ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glutamic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery
Sign in / Sign up

Export Citation Format

Share Document