scholarly journals Effect of Silk Protein Processing on Drug Delivery from Silk Films

2013 ◽  
Vol 13 (3) ◽  
pp. 311-320 ◽  
Author(s):  
Eleanor M. Pritchard ◽  
Xiao Hu ◽  
Violet Finley ◽  
Catherine K. Kuo ◽  
David L. Kaplan
Keyword(s):  
Drug Delivery ◽  
Protein Processing ◽  
Silk Protein ◽  
Silk Films

scholarly journals Air-Spun Silk-Based Micro-/Nanofibers and Thin Films for Drug Delivery

2021 ◽  
Vol 22 (17) ◽  
pp. 9588
Author(s):  
Christopher R. Gough ◽  
Xiao Hu
Keyword(s):  
Drug Delivery ◽  
Protein Structure ◽  
High Efficiency ◽  
Volume Ratio ◽  
High Porosity ◽  
Scanning Calorimetry ◽  
Fiber Network ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Silk Films

Micro-/nanofibers have shown high promise as drug delivery vehicles due to their high porosity and surface-area-to-volume ratio. The current study utilizes air-spraying, a novel fiber fabrication technique, to create silk micro-/nanofibers without the need for a high voltage power source. Air-spraying was used to create silk fibrous mats embedded with several model drugs with high efficiency. In order to compare the effect of biomaterial geometry on the release of the model drugs, silk films were also created and characterized. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and a drug release study were performed on both fiber and film samples to study how the model drugs interact with the protein structure. FTIR analysis showed that while drugs could interact with the protein structure of porous silk fibers, they could not interact with the flat geometry of silk films. As a result, fibers could protect select model drugs from thermal degradation and slow their release from the fiber network with more control than the silk films. A trend was also revealed where hydrophobic drugs were better protected and had a slower release than hydrophilic drugs. The results suggest that the physical and chemical properties of drugs and protein-based biomaterials are important for creating drug delivery vehicles with tailored release profiles and that fibers provide better tunability than films do.

scholarly journals Engineered Spider Silk Protein-Based Composites for Drug Delivery

2013 ◽  
Vol 13 (10) ◽  
pp. 1431-1437 ◽  
Author(s):  
John G. Hardy ◽  
Aldo Leal-Egaña ◽  
Thomas R. Scheibel
Keyword(s):  
Drug Delivery ◽  
Spider Silk ◽  
Silk Protein ◽  
Spider Silk Protein

Silk protein nanospheres for paclitaxel/doxorubicin synergistic drug delivery

2016 ◽  
Vol 12 (2) ◽  
pp. 554
Author(s):  
Wenhua Yang ◽  
Zhengzhong Shao ◽  
Xin Chen
Keyword(s):  
Drug Delivery ◽  
Silk Protein

Silk protein-based nanomaterials in drug delivery and biomedical applications

2021 ◽  
pp. 447-463
Author(s):  
Chowdhury Mobaswar Hossain ◽  
Dishari Dutta ◽  
Riddhi Vichare ◽  
Manas R. Biswal ◽  
Kazi Asraf Ali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Silk Protein

scholarly journals Characterization and Evaluation of Silk Protein Hydrogels for Drug Delivery

2006 ◽  
Vol 54 (2) ◽  
pp. 156-162 ◽  
Author(s):  
Jia-You Fang ◽  
Jyh-Ping Chen ◽  
Yann-Lii Leu ◽  
Hsin-Yuan Wang
Keyword(s):  
Drug Delivery ◽  
Silk Protein ◽  
Protein Hydrogels

Water-based preparation of spider silk films as drug delivery matrices

2015 ◽  
Vol 213 ◽  
pp. 134-141 ◽  
Author(s):  
Elisa Agostini ◽  
Gerhard Winter ◽  
Julia Engert
Keyword(s):  
Drug Delivery ◽  
Spider Silk ◽  
Water Based ◽  
Silk Films
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