Tunable pH-Sensitive Poly(β -amino ester)s Synthesized from Primary Amines and Diacrylates for Intracellular Drug Delivery

2012 ◽  
Vol 12 (10) ◽  
pp. 1375-1383 ◽  
Author(s):  
Wantong Song ◽  
Zhaohui Tang ◽  
Mingqiang Li ◽  
Shixian Lv ◽  
Haiyang Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Primary Amines ◽  
Amino Ester ◽  
Intracellular Drug Delivery

One-pot synthesis of pH-sensitive poly(RGD-co-β-amino ester)s for targeted intracellular drug delivery

2014 ◽  
Vol 5 (3) ◽  
pp. 844-853 ◽  
Author(s):  
Zeng-Ying Qiao ◽  
Sheng-Lin Qiao ◽  
Gang Fan ◽  
Yun-Shan Fan ◽  
Yu Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Amino Ester ◽  
One Pot ◽  
One Pot Synthesis ◽  
Intracellular Drug Delivery

pH-sensitive polyion complex micelles for tunable intracellular drug delivery

2015 ◽  
Vol 213 ◽  
pp. e55
Author(s):  
Jinjin Chen ◽  
Ying Zhang ◽  
Jianxun Ding ◽  
Chunsheng Xiao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Polyion Complex ◽  
Polyion Complex Micelles ◽  
Intracellular Drug Delivery ◽  
Complex Micelles

scholarly journals pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 952 ◽  
Author(s):  
Mengxue Zhou ◽  
Xingcai Zhang ◽  
Jin Xie ◽  
Rongxiang Qi ◽  
Huiru Lu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Ph Sensitive ◽  
Amino Ester ◽  
Stimuli Responsive ◽  
Glycoprotein P ◽  
Cell Internalization ◽  
Promising Tool ◽  
Intracellular Drug Delivery ◽  
Mcf 7

Multidrug resistance (MDR) remains an unmet challenge in chemotherapy. Stimuli-responsive nanocarriers emerge as a promising tool to overcome MDR. Herein, pH-sensitive poly(β-amino ester)s polymers (PHP)-based micellar nanoparticles were synthesized for enhanced doxorubicin (DOX) delivery in drug resistant breast cancer MCF-7/ADR cells. DOX-loaded PHP micelles showed rapid cell-internalization and lysosomal escape in MCF-7/ADR cells. The cytotoxicity assays showed relatively higher cell inhibition of DOX-loaded PHP micelles than that of free DOX against MCF-7/ADR cells. Further mechanistic studies showed that PHP micelles were able to inhibit P-glycoprotein (P-gp) activity by lowering mitochondrial membrane potentials and ATP levels. These results suggested that the enhanced antitumor effect might be attributed to PHP-mediated lysosomal escape and drug efflux inhibition. Therefore, PHP would be a promising pH-responsive nanocarrier for enhanced intracellular drug delivery and overcoming MDR in cancer cells.

pH-Sensitive nanoparticles as smart carriers for selective intracellular drug delivery to tumor

2018 ◽  
Vol 545 (1-2) ◽  
pp. 274-285 ◽  
Author(s):  
Xin-Xin Li ◽  
Jing Chen ◽  
Jian-Min Shen ◽  
Ran Zhuang ◽  
Shi-Qi Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Intracellular Drug Delivery

pH-sensitive pullulan-based nanoparticles for intracellular drug delivery

2014 ◽  
Vol 5 (2) ◽  
pp. 423-432 ◽  
Author(s):  
Yinsong Wang ◽  
Yang Liu ◽  
Yuanyuan Liu ◽  
Yan Wang ◽  
Jing Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Intracellular Drug Delivery
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