scholarly journals Efficient Intracellular siRNA Delivery by Ethyleneimine-Modified Amphiphilic Macromolecules

2011 ◽  
Vol 11 (9) ◽  
pp. 1192-1200 ◽  
Author(s):  
Sarah M. Sparks ◽  
Carolyn L. Waite ◽  
Alexander M. Harmon ◽  
Leora M. Nusblat ◽  
Charles M. Roth ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Amphiphilic Macromolecules

Polymersomes-mediated siRNA delivery for states of hormone excess

2013 ◽  
pp. 1-1
Author(s):  
Georgia Bakirtzi ◽  
Giuseppe Battaglia ◽  
Giuseppe Battaglia ◽  
John Price Newell
Keyword(s):  
Sirna Delivery

Lipid-based siRNA Delivery Systems

2012 ◽  
Vol 39 (5) ◽  
pp. 396-401 ◽  
Author(s):  
Wen-Juan DONG ◽  
Yin-Jian ZHOU ◽  
Wei LIANG
Keyword(s):  
Sirna Delivery ◽  
Delivery Systems

Multifunctional Superparamagnetic Nanoparticles: From Synthesis to siRNA Delivery

2017 ◽  
Vol 23 (16) ◽  
Author(s):  
Sanam Arami ◽  
Majid Mahdavi ◽  
Mohammad Reza Rashidi ◽  
Marziyeh Fathi ◽  
Mohammad Saeid Hejazi ◽  
...  
Keyword(s):  
Sirna Delivery ◽  
Superparamagnetic Nanoparticles

Stimuli-Responsive Nanoparticles for siRNA Delivery

2015 ◽  
Vol 21 (29) ◽  
pp. 4131-4144 ◽  
Author(s):  
Josimar Eloy ◽  
Raquel Petrilli ◽  
Renata Lopez ◽  
Robert Lee
Keyword(s):  
Sirna Delivery ◽  
Stimuli Responsive

Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers

2018 ◽  
Vol 24 (16) ◽  
pp. 1788-1800 ◽  
Author(s):  
Kye-Soo Cho ◽  
Seo-Jin Hong ◽  
Min-Hye Ahn ◽  
Sukdeb Pal ◽  
Pill-Hoon Choung ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Delivery System ◽  
Targeted Delivery ◽  
Sirna Delivery ◽  
Public Health Issue ◽  
Magic Bullet ◽  
Bodily Fluids ◽  
Low Cytotoxicity ◽  
Genetic And Environmental Factors ◽  
Sirna Delivery System

Background: Cancer poses a major public health issue, is linked with high mortality rates across the world, and shows a strong interplay between genetic and environmental factors. To date, common therapeutics, including chemotherapy, immunotherapy, and radiotherapy, have made significant contributions to cancer treatment, although diverse obstacles for achieving the permanent “magic bullet” cure have remained. Recently, various anticancer therapeutic agents designed to overcome the limitations of these conventional cancer treatments have received considerable attention. One of these promising and novel agents is the siRNA delivery system; however, poor cellular uptake and altered siRNA stability in physiological environments have limited its use in clinical trials. Therefore, developing the ideal siRNA delivery system with low cytotoxicity, improved siRNA stability in the body’s circulation, and prevention of its rapid clearance from bodily fluids, is rapidly emerging as an innovative therapeutic strategy to combat cancer. Moreover, active targeting using ligand moieties which bind to over-expressed receptors on the surface of cancer cells would enhance the therapeutic efficiency of siRNA. Conclusion: In this review, we provide 1) an overview of the non-viral carrier associated with siRNA delivery for cancer treatment, and 2) a description of the five major cancer-targeting ligands.

Nanostructured Hyaluronic Acid-based Materials for the Delivery of siRNA

2018 ◽  
Vol 24 (23) ◽  
pp. 2678-2691 ◽  
Author(s):  
Keval Shah ◽  
Sunita Chawla ◽  
Anuradha Gadeval ◽  
Goutham Reddy ◽  
Rahul Maheshwari ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Rna Interference ◽  
Sirna Delivery ◽  
Treatment Strategies ◽  
Aqueous Solubility ◽  
Micro Rna ◽  
Target Space ◽  
Significant Progress ◽  
Gene Therapies ◽  
Future Potential

Background: The search for the effective treatment strategies to combat a disease that is characterized by abnormal cell growth and known as cancer is still required to reach its destiny. To address the problem, recently several gene therapies based on novel RNA interference (RNAi) have been proposed such as siRNA, micro RNA, shRNA, etc. out of which, siRNAs (silencing RNA) promises to show significant progress in pharmacotherapy, including considerable expansion of the druggable target space and the possibility of treating cancer. Methods: This review aims to uncover the hyaluronic acid (HA) and HA-hybridized nanoplatforms for siRNA delivery systems with a particular focus on the discussion of available reports while addressing the future potential of HA-based treatment strategies. Results: HA modified siRNA delivery, as promised, provided better targeting potential in many types of cancers. In addition, it was able to modify the release of siRNA as well. Toxicity of HA is well mentioned however, the loophole is yet to be filled by exploring various remedies for overcoming toxicity. Conclusion: To overcome the problems associated with these emerging genetic tools, investigators have employed glycosaminoglycan HA-based biopolymers. This biopolymer offers a variety of properties such as biodegradability, biocompatibility, aqueous solubility, viscoelasticity, and non-immunogenicity.

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