Biodegradable Glutaraldehyde-crosslinked Casein Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats

2011 ◽  
Vol 11 (7) ◽  
pp. 914-926 ◽  
Author(s):  
Walter Wang ◽  
Jia-Horng Lin ◽  
Chin-Chuan Tsai ◽  
Hao-Che Chuang ◽  
Chien-Yi Ho ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Adult Rats

Regenerative potential of silk conduits in repair of peripheral nerve injury in adult rats

Biomaterials ◽  
2012 ◽  
Vol 33 (1) ◽  
pp. 59-71 ◽  
Author(s):  
W. Huang ◽  
R. Begum ◽  
T. Barber ◽  
V. Ibba ◽  
N.C.H. Tee ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Adult Rats

scholarly journals Biodegradable Bisvinyl Sulfonemethyl-crosslinked Gelatin Conduit Promotes Regeneration after Peripheral Nerve Injury in Adult Rats

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chien-Hsin Ko ◽  
Ming-You Shie ◽  
Jia-Horng Lin ◽  
Yi-Wen Chen ◽  
Chun-Hsu Yao ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Adult Rats

Survival and regeneration of cutaneous and muscular afferent neurons after peripheral nerve injury in adult rats

2007 ◽  
Vol 186 (2) ◽  
pp. 315-323 ◽  
Author(s):  
Dag Welin ◽  
Liudmila N. Novikova ◽  
Mikael Wiberg ◽  
Jan-Olof Kellerth ◽  
Lev N. Novikov
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Afferent Neurons ◽  
Adult Rats

Biodegradable fibrin conduit promotes long-term regeneration after peripheral nerve injury in adult rats

2010 ◽  
Vol 63 (11) ◽  
pp. 1893-1899 ◽  
Author(s):  
Jonas Pettersson ◽  
Daniel Kalbermatten ◽  
Aleksandra McGrath ◽  
Liudmila N. Novikova
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Adult Rats

Melatonin attenuates neuronal NADPH-d/NOS expression in the hypoglossal nucleus of adult rats following peripheral nerve injury

2000 ◽  
Vol 873 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Hung-Ming Chang ◽  
Eng-Ang Ling ◽  
June-Horng Lue ◽  
Chen-Yuan Wen ◽  
Jeng-Yung Shieh
Keyword(s):  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Hypoglossal Nucleus ◽  
Adult Rats

Age-Dependent Schwann Cell Phenotype Regulation Following Peripheral Nerve Injury

2017 ◽  
Vol 22 (04) ◽  
pp. 464-471 ◽  
Author(s):  
Wayne A. Chen ◽  
T. David Luo ◽  
Jonathan C. Barnwell ◽  
Thomas L. Smith ◽  
Zhongyu Li
Keyword(s):  
Young Adult ◽  
Schwann Cell ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Functional Recovery ◽  
Peripheral Nerve Injury ◽  
Adolescent And Young Adult ◽  
Post Injury ◽  
Adult Rats ◽  
Regulatory Factors

Background: Schwann cells are integral to the regenerative capacity of the peripheral nervous system, which declines after adolescence. The mechanisms underlying this decline are poorly understood. This study sought to compare the protein expression of Notch, c-Jun, and Krox-20 after nerve crush injury in adolescent and young adult rats. We hypothesized that these Schwann cell myelinating regulatory factors are down-regulated after nerve injury in an age-dependent fashion. Methods: Adolescent (2 months old) and young adult (12 months old) rats (n = 48) underwent sciatic nerve crush injury. Protein expression of Notch, c-Jun, and Krox-20 was quantified by Western blot analysis at 1, 3, and 7 days post-injury. Functional recovery was assessed in a separate group of animals (n = 8) by gait analysis (sciatic functional index) and electromyography (compound motor action potential) over an 8-week post-injury period. Results: Young adult rats demonstrated a trend of delayed onset of the dedifferentiating regulatory factors, Notch and c-Jun, corresponding to the delayed functional recovery observed in young adult rats compared to adolescent rats. Compound motor action potential area was significantly greater in adolescent rats relative to young adult rats, while amplitude and velocity trended toward statistical significance. Conclusions: The process of Schwann cell dedifferentiation following peripheral nerve injury shows different trends with age. These trends of delayed onset of key regulatory factors responsible for Schwann cell myelination may be one of many possible factors mediating the significant differences in functional recovery between adolescent and young adult rats following peripheral nerve injury.

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