Photopolymerized Injectable RGD-Modified Fumarated Poly(ethylene glycol) Diglycidyl Ether Hydrogels for Cell Growth

2008 ◽  
Vol 8 (9) ◽  
pp. 852-862 ◽  
Author(s):  
Z. Seden Akdemir ◽  
Handan Akçakaya ◽  
M. Vezir Kahraman ◽  
Taşkın Ceyhan ◽  
Nilhan Kayaman-Apohan ◽  
...  
Keyword(s):  
Cell Growth ◽  
Ethylene Glycol ◽  
Diglycidyl Ether ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Synthesis of Network Polymers by Means of Addition Reactions of Multifunctional-Amine and Poly(ethylene glycol) Diglycidyl Ether or Diacrylate Compounds

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2047
Author(s):  
Naofumi Naga ◽  
Mitsusuke Sato ◽  
Kensuke Mori ◽  
Hassan Nageh ◽  
Tamaki Nakano
Keyword(s):  
Ethylene Glycol ◽  
Room Temperature ◽  
Addition Reaction ◽  
Monomer Concentration ◽  
Diglycidyl Ether ◽  
Porous Polymers ◽  
Addition Reactions ◽  
Poly Ethylene Glycol ◽  
Network Polymers ◽  
Poly Ethylene

Addition reactions of multi-functional amine, polyethylene imine (PEI) or diethylenetriamine (DETA), and poly(ethylene glycol) diglycidyl ether (PEGDE) or poly(ethylene glycol) diacrylate (PEGDA), have been investigated to obtain network polymers in H2O, dimethyl sulfoxide (DMSO), and ethanol (EtOH). Ring opening addition reaction of the multi-functional amine and PEGDE in H2O at room temperature or in DMSO at 90 °C using triphenylphosphine as a catalyst yielded gels. Aza-Michael addition reaction of the multi-functional amine and PEGDA in DMSO or EtOH at room temperature also yielded corresponding gels. Compression test of the gels obtained with PEI showed higher Young’s modulus than those with DETA. The reactions of the multi-functional amine and low molecular weight PEGDA in EtOH under the specific conditions yielded porous polymers induced by phase separation during the network formation. The morphology of the porous polymers could be controlled by the reaction conditions, especially monomer concentration and feed ratio of the multi-functional amine to PEGDA of the reaction system. The porous structure was formed by connected spheres or a co-continuous monolithic structure. The porous polymers were unbreakable by compression, and their Young’s modulus increased with the increase in the monomer concentration of the reaction systems. The porous polymers absorbed various solvents derived from high affinity between the polyethylene glycol units in the network structure and the solvents.

scholarly journals Toxicity Assessment of a Single Dose of Poly(ethylene glycol) Diglycidyl Ether (PEGDE) Administered Subcutaneously in Mice

Toxics ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 354
Author(s):  
Do-Hyun Kim ◽  
Jong-Hyeon Han ◽  
Hyuk-Cheol Kwon ◽  
Su-Jin Lim ◽  
Seo-Gu Han ◽  
...  
Keyword(s):  
Body Weight ◽  
Ethylene Glycol ◽  
Feed Intake ◽  
Diglycidyl Ether ◽  
Organ Weight ◽  
The Body ◽  
The Other ◽  
Poly Ethylene Glycol ◽  
Weight Variation ◽  
Poly Ethylene

Poly(ethylene glycol) diglycidyl ether (PEGDE) is widely used to cross-link polymers, particularly in the pharmaceutical and biomaterial sectors. However, the subcutaneous toxicity of PEGDE has not yet been assessed. PEGDE samples (500–40,000 μg/mouse) were subcutaneously injected into the paraspinal dorsum of BALB/c male mice. Cage-side observations were carried out with measurement of organ weight, body weight variation, and feed intake, as well as histopathological characterization on day 28 post-exposure. Mice that received 40,000 μg of PEGDE showed severe toxic response and had to be euthanized. Subcutaneous injection of PEGDE did not alter feed intake and organ weight; however, the body weight variation of mice injected with 20,000 μg of PEGDE was significantly lower than that of the other groups. Exposure to 10,000 and 20,000 μg of PEGDE induced epidermal ulcer formation and hair loss. The histology of skin tissue in mice administered with 20,000 μg of PEGDE showed re-epithelialized or unhealed wounds. However, the liver, spleen, and kidneys were histologically normal. Collectively, PEGDE, particularly above 10,000 μg/mouse, caused subcutaneous toxicity with ulceration, but no toxicity in the other organs. These results may indicate the optimal concentration of subcutaneously injected PEGDE.

Activation of pine kraft lignin by Fenton-type oxidation for cross-linking with oligo(oxyethylene) diglycidyl ether

Holzforschung ◽  
2011 ◽  
Vol 65 (3) ◽  
Author(s):  
Lars Passauer ◽  
Klaus Fischer ◽  
Falk Liebner
Keyword(s):  
Ethylene Glycol ◽  
Water Sorption ◽  
Structural Changes ◽  
Kraft Lignin ◽  
Diglycidyl Ether ◽  
Fenton Oxidation ◽  
Cross Linking ◽  
Ferrous Chloride ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Abstract Mechanically stable hydrogels featuring water absorption capacities of up to 75 gH2O ggel -1 can be obtained by cross-linking of activated technical lignins with poly(ethylene) glycol diglycidyl ether under strong alkaline conditions. Fenton oxidation prior to cross-linking by hydrogen peroxide and catalytic amounts of ferrous chloride has been found to be superior to an alkaline H2O2 pre-treatment with respect to gel formation, water sorption, and rheological properties of the resulting oligo(oxyethylene) lignin gels. Purified pine kraft lignin undergoes in the course of Fenton oxidation hydroxylation of both aliphatic and aromatic moieties. This is the main reason for the enhanced cross-linking density obtained after treatment with poly(ethylene) glycol diglycidyl ether. The oxidative changes have been demonstrated by principal component analysis of Curie point pyrograms, wet chemical methods, FT-IR, and 31P NMR spectroscopy. Cleavage of side-chains, radical 5,5′-coupling of phenylpropane units, formation of carbonyl and carboxyl groups, and cleavage of aromatic rings were observed. These structural changes may increase or decrease the water sorption capability of the cross-linked products.

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