Ionic Complexes of Biosynthetic Poly(malic acid) and Poly(glutamic acid) as Prospective Drug-Delivery Systems

2007 ◽  
Vol 7 (7) ◽  
pp. 897-906 ◽  
Author(s):  
Jose A. Portilla-Arias ◽  
Montserrat García-Alvarez ◽  
Antxon Martínez de Ilarduya ◽  
Sebastián Muñoz-Guerra
Keyword(s):  
Drug Delivery ◽  
Glutamic Acid ◽  
Malic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ionic Complexes

pH-responsive drug delivery systems based on clickable poly(L-glutamic acid)-grafted comb copolymers

2012 ◽  
Vol 20 (3) ◽  
pp. 292-301 ◽  
Author(s):  
Jianxun Ding ◽  
Chaoliang He ◽  
Chunsheng Xiao ◽  
Jie Chen ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Glutamic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Responsive

scholarly journals Comblike Ionic Complexes of Hyaluronic Acid and Alkanoylcholine Surfactants as a Platform for Drug Delivery Systems

2018 ◽  
Vol 19 (9) ◽  
pp. 3669-3681
Author(s):  
Ana Gamarra ◽  
Sebastián Muñoz-Guerra ◽  
Antxon Martínez de Ilarduya ◽  
Héloïse Thérien-Aubin ◽  
Katharina Landfester
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ionic Complexes

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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