Amphiphilic Poly(D,L-lactic acid)/Poly(ethylene glycol)/Poly(D,L-lactic acid) Nanogels for Controlled Release of Hydrophobic Drugs

2006 ◽  
Vol 6 (10) ◽  
pp. 846-854 ◽  
Author(s):  
Wen-Chuan Lee ◽  
Yuan-Chung Li ◽  
I-Ming Chu
Keyword(s):  
Lactic Acid ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Hydrophobic Drugs ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(ethylene glycol) Methacrylate/Dimethacrylate Hydrogels for Controlled Release of Hydrophobic Drugs

2008 ◽  
Vol 21 (4) ◽  
pp. 1281-1288 ◽  
Author(s):  
Jackie A. DiRamio ◽  
William S. Kisaalita ◽  
George F. Majetich ◽  
Joel M. Shimkus
Keyword(s):  
Controlled Release ◽  
Ethylene Glycol ◽  
Hydrophobic Drugs ◽  
Poly Ethylene Glycol ◽  
Glycol Methacrylate ◽  
Poly Ethylene

scholarly journals Instantaneous Degelling Thermoresponsive Hydrogel

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 169
Author(s):  
Noam Y. Steinman ◽  
Abraham J. Domb
Keyword(s):  
Lactic Acid ◽  
Controlled Release ◽  
Ethylene Glycol ◽  
Disulfide Bonds ◽  
Hydrolytic Degradation ◽  
Poly Lactic Acid ◽  
Hydrolytic Cleavage ◽  
Poly Ethylene Glycol ◽  
Thermoresponsive Polymer ◽  
Poly Ethylene

Responsive polymeric hydrogels have found wide application in the clinic as injectable, biocompatible, and biodegradable materials capable of controlled release of therapeutics. In this article, we introduce a thermoresponsive polymer hydrogel bearing covalent disulfide bonds. The cold aqueous polymer solution forms a hydrogel upon heating to physiological temperatures and undergoes slow degradation by hydrolytic cleavage of ester bonds. The disulfide functionality allows for immediate reductive cleavage of the redox-sensitive bond embedded within the polymer structure, affording the option of instantaneous hydrogel collapse. Poly (ethylene glycol)-b-poly (lactic acid)-S-S-poly (lactic acid)-b-poly (ethylene glycol) (PEG-PLA-SS-PLA-PEG) copolymer was synthesized by grafting PEG to PLA-SS-PLA via urethane linkages. The aqueous solution of the resultant copolymer was a free-flowing solution at ambient temperatures and formed a hydrogel above 32 °C. The immediate collapsibility of the hydrogel was displayed via reaction with NaBH4 as a relatively strong reducing agent, yet stability was displayed even in glutathione solution, in which the polymer degraded slowly by hydrolytic degradation. The polymeric hydrogel is capable of either long-term or immediate degradation and thus represents an attractive candidate as a biocompatible material for the controlled release of drugs.

Controlled Release Behaviors of Ketoprofen from Matrix Polymer of Chitosan and poly(ethylene glycol)

2013 ◽  
Vol 813 ◽  
pp. 399-402
Author(s):  
Chimsook Thitipha ◽  
Thitiphan Chimsook
Keyword(s):  
Particle Size ◽  
Controlled Release ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Diffusion Method ◽  
Poly Ethylene Glycol ◽  
Matrix Polymer ◽  
Percentage Yield ◽  
Poly Ethylene ◽  
Composition Ratios

The aim of present work was to prepare floating microsphere of ketoprofen using matrix polymer of chitosan and poly (ethylene glycol) by solvent diffusion method. The floating microsphere of ketoprofen was prepared from matrix polymer of chitosan and poly (ethylene glycol) with various composition ratios and evaluated such as particle size, drug compatibility and drug release of microspheres. The scanning electron microscopy of microspheres confirmed their hollow structures with smooth surface. Formulation CPK 4 to CPK 6 exhibited the best controlled release pattern in ketoprofen. The concentration and size of poly (ethylene-glycol) affected the particle size, percentage yield and drug release of microspheres.

The effect of poly(ethylene glycol) as plasticizer in blends of poly(lactic acid) and poly(butylene succinate)

2015 ◽  
Vol 133 (8) ◽  
pp. n/a-n/a ◽  
Author(s):  
Weraporn Pivsa-Art ◽  
Kazunori Fujii ◽  
Keiichiro Nomura ◽  
Yuji Aso ◽  
Hitomi Ohara ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Butylene Succinate ◽  
Poly Ethylene

scholarly journals Modeling of the Degradation of Poly(ethylene glycol)-co-(lactic acid)-dimethacrylate Hydrogels

2017 ◽  
Vol 50 (14) ◽  
pp. 5527-5538 ◽  
Author(s):  
Vincent E. G. Diederich ◽  
Thomas Villiger ◽  
Giuseppe Storti ◽  
Marco Lattuada
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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