Domino liver transplantation for familial amyloid polyneuropathy

1998 ◽  
Vol 4 (3) ◽  
pp. 236-238 ◽  
Author(s):  
Alan W. Hemming ◽  
Mark S. Cattral ◽  
Ravi S. Chari ◽  
Paul D. Greig ◽  
Leslie B. Lilly ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Familial Amyloid Polyneuropathy ◽  
Amyloid Polyneuropathy ◽  
Domino Liver Transplantation

Domino Liver Transplantation: A Practical Option in the Face of the Organ Shortage

2003 ◽  
Vol 13 (2) ◽  
pp. 151-153
Author(s):  
Maria T. Carrera ◽  
Eileen Heanue Bogue ◽  
Thomas D. Schiano
Keyword(s):  
Liver Transplantation ◽  
Genetic Defect ◽  
Familial Amyloid Polyneuropathy ◽  
Definitive Treatment ◽  
Mutant Form ◽  
Organ Shortage ◽  
Explanted Liver ◽  
Amyloid Polyneuropathy ◽  
Domino Liver Transplantation

This case study describes a domino liver transplantation in which a patient with familial amyloid polyneuropathy received a cadaveric liver, and the explanted liver was in turn transplanted into a second recipient. Familial amyloid polyneuropathy is an autosomal dominant inherited disease associated with a mutant form of the protein transthyretin. Liver transplantation is the only definitive treatment for this disease. Transplantation removes the source of mutant transthyretin, halts the progression of this otherwise fatal disease, and significantly palliates many underlying symptoms. This case study illustrates that domino transplantation is a practical option to provide a liver transplant for a patient with this disease and a second listed patient from a single cadaveric liver organ, thus alleviating the organ donor shortage. Transplantation offers the only cure for the genetic defect that causes familial amyloid polyneuropathy, appears to result in subjective and objective improvement in neurological function, and eliminates the mortality associated with the disease. A signed informed consent was provided for publication of this case study.

Domino liver transplantation as a cause of acquired familial amyloid polyneuropathy

Amyloid ◽  
2014 ◽  
Vol 21 (2) ◽  
pp. 136-137 ◽  
Author(s):  
Mohamed M. Abdelfatah ◽  
Suzanne R. Hayman ◽  
Morie A. Gertz
Keyword(s):  
Liver Transplantation ◽  
Familial Amyloid Polyneuropathy ◽  
Amyloid Polyneuropathy ◽  
Domino Liver Transplantation

scholarly journals FAMILIAL AMYLOID POLYNEUROPATHY DOMINO LIVER TRANSPLANTATION: WHAT DID WE DO RIGHT?

2020 ◽  
Vol 104 (S3) ◽  
pp. S58-S59
Author(s):  
Ahmad Karadagi ◽  
Viktor Renneus Guthrie ◽  
Felicia Kjaernet ◽  
Antonio Romano ◽  
Bo-Göran Ericzon ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Familial Amyloid Polyneuropathy ◽  
Amyloid Polyneuropathy ◽  
Domino Liver Transplantation
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