Liver transplantation in short‐telomere‐mediated hepatopulmonary syndrome following bone marrow transplantion, using HCV positive allografts: a case series

2021 ◽  
Author(s):  
Abdul M. Oseini ◽  
James P. Hamilton ◽  
Muhammad Baraa Hammam ◽  
Ahyoung Kim ◽  
Kiyoko Oshima ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Liver Transplantation ◽  
Case Series ◽  
Hepatopulmonary Syndrome ◽  
Short Telomere

Successful liver transplantation in short telomere syndromes without bone marrow failure due to DKC1 mutation

2020 ◽  
Vol 24 (3) ◽  
Author(s):  
Rodrigo del Brío Castillo ◽  
Jacob Bleesing ◽  
Thomas McCormick ◽  
James E. Squires ◽  
George V. Mazariegos ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Liver Transplantation ◽  
Bone Marrow Failure ◽  
Short Telomere

scholarly journals The Successful Use of Inhaled Nitric Oxide in the Management of Severe Hepatopulmonary Syndrome after Orthotopic Liver Transplantation

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Joshua Santos ◽  
Philip Young ◽  
Igor Barjaktarevic ◽  
Catherine Lazar ◽  
Irawan Susanto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Transplantation ◽  
Postoperative Period ◽  
Animal Studies ◽  
Case Series ◽  
Hepatopulmonary Syndrome ◽  
Early Postoperative Period ◽  
Inhaled Nitric Oxide ◽  
Pulmonary Vasodilation ◽  
Refractory Life

Hepatopulmonary syndrome (HPS) is characterized by pulmonary vasodilation and subsequent hypoxemia in the setting of hepatic dysfunction. There is currently no pharmacologic intervention that has been shown to significantly affect outcomes and liver transplantation remains the mainstay of therapy. Unfortunately, patients undergoing liver transplantation are at high risk of significant hypoxemia and mortality in the early postoperative period. In the following case series, we present two cases of patients with severe HPS who underwent liver transplantation and experienced marked hypoxemia in the early postoperative period. In both cases, we successfully treated the patients with inhaled nitric oxide for their severe refractory life-threatening hypoxemia which led to immediate and dramatic improvements in their oxygenation. Although the use of inhaled nitric oxide in patients with HPS has been sporadically reported in pediatric literature and in animal studies, to our knowledge, our cases are the first recorded in adult patients.

Impact of hypoxemia on pediatric liver transplantation for hepatopulmonary syndrome

2021 ◽  
Author(s):  
Plínio Turine Neto ◽  
João Seda Neto ◽  
Eduardo Antunes Fonseca ◽  
Gilda Porta ◽  
Renata Pugliese ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatopulmonary Syndrome ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver

scholarly journals Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Jean-Philippe Hauzeur ◽  
Valérie Gangji
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Adult Stem Cells ◽  
Bone Marrow Aspirate ◽  
Direct Injection ◽  
Case Series ◽  
Autologous Bone Marrow ◽  
Bone Necrosis ◽  
Concentrated Bone Marrow ◽  
Made In

Nonunion fractures and aseptic bone necrosis are two pathological conditions having some impairment of the cellular part of the repair: a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies using stem cells. We made a review of the published human trials. Only autologous bone marrow aspirate implantation was until now used. In Nonunion, a direct injection—15 to 150 ml—was made in 4 case series studies. In another, the bone marrow aspirate was concentrated before injection. The results were good. In bone necrosis, only one level 1 study was published. The results at 24 months were positive in terms of reduction of the necrosis and appearance of collapse. In 3 case series studies, a treatment with concentrated bone marrow aspirates was deemed useful with good results in 76 to 96%. These results are interesting but need confirmation by controlled studies.

Immunosuppression and probiotics: are they effective and safe?

2015 ◽  
Vol 6 (6) ◽  
pp. 823-828 ◽  
Author(s):  
V. Stadlbauer
Keyword(s):  
Bone Marrow ◽  
Liver Transplantation ◽  
Liver Cirrhosis ◽  
Bone Marrow Transplantation ◽  
Probiotic Bacteria ◽  
Major Surgery ◽  
Efficacy And Safety ◽  
Immunosuppressed Patients ◽  
Patient Groups ◽  
Prophylaxis Of Infections

This opinion statement discusses indications, efficacy and safety of probiotics in immunosuppressed patients. The best evidence available is for the prophylaxis of infections in patients after liver transplantation and for patients with liver cirrhosis. For other organ transplantations and for bone marrow transplantation the efficacy of probiotic interventions has not been proven yet, but in these patient groups safety is a concern. Also in critically ill patients, the data on efficacy are inconclusive and safety is a concern. In HIV patients and patients after major surgery, probiotic bacteria seem to be safe since there are no associations with increased risks of side effects.

scholarly journals Return to Sports After Bone Marrow–Derived Cell Transplantation for Osteochondral Lesions of the Talus

Cartilage ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 80-87 ◽  
Author(s):  
Francesca Vannini ◽  
Marco Cavallo ◽  
Laura Ramponi ◽  
Francesco Castagnini ◽  
Simone Massimi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Transplantation ◽  
Case Series ◽  
Clinical Results ◽  
Osteochondral Lesions ◽  
Return To Sports ◽  
One Step ◽  
American Orthopaedic ◽  
Return To Activity

Objective Arthroscopic “one-step” technique based on bone marrow–derived cell transplantation (BMDCT) have achieved good results in repairing osteochondral lesions of the talus (OLT), overcoming important drawbacks of older techniques. It may be particularly adequate for the treatment of athletes in order to permit a safe and stable return to sports. The aim of this study was to report the results at 48 months of a series of athletes and the factors influencing the return to sports. Design Case series. A total of 140 athletes underwent a “one-step” BMDCT repair of OLT. All the patients had the cells harvested from the iliac crest, condensed and loaded on a scaffold, and then implanted. Patients were evaluated clinically by the American Orthopaedic Foot and Ankle Society (AOFAS) scores and Halasi score. Results AOFAS score improved from 58.7 ± 13.5 preoperatively to 90.6 ± 8.6 ( P < 0.005) at 24 months, and to 90.9 ± 10.7 at 48 months. Halasi score was 6.88 ± 1.8 preinjury, 4.08 ± 1.7 preoperatively, and 5.56 ± 2.0 at final follow-up. At the final follow-up, all the patients (beside 1 failure and 3 lost) were able to return to activity and 72.8% were able to resume sports at preinjury level. Conclusions “One-step” BMDCT repair of OLT had good clinical results that was durable over time in athletes, permitting a return to sports at preinjury level in the majority of patients. The preoperative presence of impingement and articular degeneration were the main negative prognostic factors.

Sign in / Sign up

Export Citation Format

Share Document