What Role Should Acute‐on‐Chronic Liver Failure Play in Liver Transplant Prioritization? A Survey of US‐Based Transplant Providers

2020 ◽  
Vol 26 (12) ◽  
pp. 1658-1661 ◽  
Author(s):  
Jasmohan S. Bajaj ◽  
Elizabeth C. Verna
Keyword(s):  
Liver Failure ◽  
Liver Transplant ◽  
Chronic Liver ◽  
Chronic Liver Failure

Systematic review with meta-analysis: liver transplant provides survival benefit in patients with acute on chronic liver failure

2020 ◽  
Vol 52 (2) ◽  
pp. 222-232 ◽  
Author(s):  
Mohamed A. Abdallah ◽  
Muhammad Waleed ◽  
Matthew G. Bell ◽  
Morgan Nelson ◽  
Robert Wong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Failure ◽  
Liver Transplant ◽  
Survival Benefit ◽  
Meta Analysis ◽  
Chronic Liver ◽  
Chronic Liver Failure

Iso and Xeno Fetal Liver Transplant Therapy for the Treatment of Acute and Chronic Liver Failure in Rats

1994 ◽  
Vol 3 (1_suppl) ◽  
pp. 29-30 ◽  
Author(s):  
Masao Hagihara ◽  
Tatsuo Shimura ◽  
Kentarou∕ Takebe ◽  
Munkhbatø Batømunkh ◽  
Kimiyoshi Tsuji
Keyword(s):  
Liver Failure ◽  
Liver Transplant ◽  
Fetal Liver ◽  
Chronic Liver ◽  
Chronic Liver Failure

scholarly journals Longitudinal Renal Function in Liver Transplant Recipients With Acute-on-Chronic Liver Failure

2020 ◽  
Vol 11 (6) ◽  
pp. e00185
Author(s):  
Masahiko Yazawa ◽  
Benedict Maliakkal ◽  
Satheesh Nair ◽  
Pradeep S. B. Podila ◽  
Uchenna A. Agbim ◽  
...  
Keyword(s):  
Renal Function ◽  
Liver Failure ◽  
Liver Transplant ◽  
Chronic Liver ◽  
Transplant Recipients ◽  
Chronic Liver Failure ◽  
Liver Transplant Recipients

scholarly journals Pre and post-liver transplant outcome of cirrhotic patients with acute on chronic liver failure

Medicine ◽  
2020 ◽  
Vol 99 (44) ◽  
pp. e22419
Author(s):  
Speranta Iacob ◽  
Mihaela Ghioca ◽  
Irma Eva Csiki ◽  
Dana Tomescu ◽  
Gabriela Droc ◽  
...  
Keyword(s):  
Liver Failure ◽  
Liver Transplant ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Transplant Outcome ◽  
Cirrhotic Patients

scholarly journals Dynamic Prognostication in Transplant Candidates with Acute-on-Chronic Liver Failure

2020 ◽  
Vol 10 (4) ◽  
pp. 230
Author(s):  
Cheng-Yueh Lu ◽  
Chi-Ling Chen ◽  
Cheng-Maw Ho ◽  
Chih-Yang Hsiao ◽  
Yao-Ming Wu ◽  
...  
Keyword(s):  
Liver Failure ◽  
Liver Transplant ◽  
Protective Factor ◽  
Multivariable Analysis ◽  
Chronic Liver ◽  
Clinical Markers ◽  
Chronic Liver Failure ◽  
Live Donors ◽  
Severity Scores ◽  
Tertiary Center

We aimed to extensively investigate clinical markers that are sufficiently dynamic for prognosis of acute-on-chronic liver failure (ACLF). Defined by the Asian Pacific Association for the Study of the Liver (APASL) criteria, patients with ACLF on the liver transplant waitlist in a tertiary center were retrospectively reviewed. Laboratory results and severity scores at three time points (days 1, 7, and 14 after admission) were analyzed. From 2015 to 2019, 64 patients with ACLF were enrolled, of which 24 received a liver transplant from 22 live donors. The hospital mortality rate was 31% (8% for transplant; 45% for nontransplant groups), and the 3-month survival was crucial for determining long-term outcomes. The number of significant variables for mortality, and, specifically, the hazards of international normalized ratio of prothrombin time (INR) and APASL ACLF Research Consortium (AARC) score were increased within two weeks. In multivariable analysis, INR and AARC score (D-14) were associated with poor survival and liver transplant was a protective factor in all patients, while AARC score (D-14) was significant in the nontransplant group. AARC score at day 14 is an independent risk factor for mortality in ACLF. Liver transplant from live donors reversed poor outcomes in patients with ACLF in a timely manner.

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