Differential Impact of Extended Criteria Donors After Brain Death or Circulatory Death in Adult Liver Transplantation

2020 ◽  
Vol 26 (12) ◽  
pp. 1603-1617 ◽  
Author(s):  
Keval Pandya ◽  
Vinay Sastry ◽  
Mara T. Panlilio ◽  
Terry C. F. Yip ◽  
Shirin Salimi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Brain Death ◽  
Differential Impact ◽  
Adult Liver ◽  
Extended Criteria Donors ◽  
Circulatory Death

scholarly journals Outcomes of Adult Liver Transplantation from Donation After Brain Death Followed by Circulatory Death in China

2018 ◽  
Vol 23 ◽  
pp. 285-291 ◽  
Author(s):  
Jiabin Zhang ◽  
Hui Ren ◽  
Yanling Sun ◽  
Zhijie Li ◽  
Hongbo Wang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Brain Death ◽  
Adult Liver ◽  
Donation After Brain Death ◽  
Circulatory Death

scholarly journals Mass Spectrometry Based Metabolomics Comparison of Liver Grafts from Donors after Circulatory Death (DCD) and Donors after Brain Death (DBD) Used in Human Orthotopic Liver Transplantation

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165884 ◽  
Author(s):  
Olga Hrydziuszko ◽  
M. Thamara P. R. Perera ◽  
Richard Laing ◽  
Jennifer Kirwan ◽  
Michael A. Silva ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liver Transplantation ◽  
Brain Death ◽  
Orthotopic Liver Transplantation ◽  
Circulatory Death

scholarly journals “Liver Transplantation for Hepatocellular Carcinoma using Grafts from Uncontrolled Circulatory Death Donation Versus Brain Death Donation” 

2021 ◽  
Author(s):  
Anisa Nutu ◽  
Iago Justo ◽  
Alberto Marcacuzco ◽  
Óscar Caso ◽  
Alejandro Manrique ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Brain Death ◽  
Graft Survival ◽  
Patient Survival ◽  
Similar Patient ◽  
Serum Alpha Fetoprotein ◽  
Recipient Age ◽  
Hcc Recurrence ◽  
Circulatory Death

Abstract Controversy exists regarding whether the rate of hepatocellular carcinoma (HCC) recurrence after orthotopic liver transplantation (OLT) differs when using livers from donation after controlled circulatory death (DCD) versus livers from donation after brain death (DBD). The aim of this cohort study was to analyze rates of HCC recurrence, patient survival, and graft survival after OLT for HCC, comparing recipients of DBD livers (n=103) with recipients of uncontrolled DCD livers (uDCD; n=41). No significant differences in tumor size, tumor number, serum alpha-fetoprotein, proportion of patients within Milan criteria, or pre-OLT bridging therapies were identified between groups, although the waitlist period was significantly shorter in the uDCD group (p=0.04). HCC recurrence was similar between groups. Patient survival was similar between groups, but graft survival was lower in the uDCD group. Multivariate analysis identified recipient age (p=0.03), pre-OLT bridging therapy (p=0.02), and HCC recurrence (p=0.04) as independent risk factors for patient survival and pre-OLT transarterial chemoembolization (p=0.04) as the single risk factor for HCC recurrence. In conclusion, similar patient survival and lower graft survival were observed in the uDCD group. However, the use of uDCD livers appears to be justified due to shorter waitlist time and similar HCC recurrence in both groups.

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