The New Horizon of Split‐Liver Transplantation: Ex Situ Liver Splitting During Hypothermic Oxygenated Machine Perfusion

2020 ◽  
Vol 26 (10) ◽  
pp. 1363-1367 ◽  
Author(s):  
Marco Spada ◽  
Roberta Angelico ◽  
Chiara Grimaldi ◽  
Paola Francalanci ◽  
Maria Cristina Saffioti ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ex Situ ◽  
Machine Perfusion ◽  
Split Liver Transplantation ◽  
Split Liver

scholarly journals Ex Situ Dual Hypothermic Oxygenated Machine Perfusion for Human Split Liver Transplantation

2021 ◽  
Vol 7 (3) ◽  
pp. e666
Author(s):  
Adam M. Thorne ◽  
Veerle Lantinga ◽  
Silke Bodewes ◽  
Ruben H. J. de Kleine ◽  
Maarten W. Nijkamp ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ex Situ ◽  
Machine Perfusion ◽  
Split Liver Transplantation ◽  
Split Liver

Results after Adult Ex Situ Split Liver Transplantation Since 1987 and the Influence of Biliary Complications

2012 ◽  
Vol 94 (10S) ◽  
pp. 403
Author(s):  
H. Schrem ◽  
L. Zachau ◽  
T. Lankisch ◽  
L. Kousoulas ◽  
H. Bektas ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Biliary Complications ◽  
Ex Situ ◽  
Split Liver Transplantation ◽  
Split Liver

Combination splitting using both in situ and ex situ techniques in triple split-liver transplantation of pigs

1998 ◽  
Vol 30 (7) ◽  
pp. 3223-3224 ◽  
Author(s):  
S Hayashi ◽  
T Nagasaka ◽  
T Kojima ◽  
Y Namii ◽  
A Katayama ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ex Situ ◽  
Split Liver Transplantation ◽  
Split Liver

scholarly journals Long-Term Results After Adult Ex Situ Split Liver Transplantation Since Its Introduction in 1987

2014 ◽  
Vol 38 (7) ◽  
pp. 1795-1806 ◽  
Author(s):  
Harald Schrem ◽  
Moritz Kleine ◽  
Tim Oliver Lankisch ◽  
Alexander Kaltenborn ◽  
Lampros Kousoulas ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ex Situ ◽  
Long Term Results ◽  
Split Liver Transplantation ◽  
Split Liver

scholarly journals Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia–reperfusion injury

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daisuke Ishii ◽  
Naoto Matsuno ◽  
Mikako Gochi ◽  
Hiroyoshi Iwata ◽  
Tatsuya Shonaka ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Autologous Blood ◽  
Graft Function ◽  
Machine Perfusion ◽  
Perfusion System ◽  
Split Liver Transplantation ◽  
Split Liver

AbstractThis study examined the efficacy of end-ischemic hypothermic oxygenated machine perfusion preservation (HOPE) using an originally developed machine perfusion system for split-liver transplantation. Porcine split-liver grafts were created via 75% liver resection after 10 min of warm ischemia. In Group 1, grafts were preserved by simple cold storage (CS) for 8 h (CS group; n = 4). In Group 2, grafts were preserved by simple CS for 6 h and end-ischemic HOPE for 2 h (HOPE group; n = 5). All grafts were evaluated using an isolated ex vivo reperfusion model with autologous blood for 2 h. Biochemical markers (aspartate aminotransferase and lactate dehydrogenase levels) were significantly better immediately after reperfusion in the HOPE group than in the CS group. Furthermore, the HOPE group had a better histological score. The levels of inflammatory cytokines (tumor necrosis factor-α, interferon-γ, interleukin-1β, and interleukin-10) were significantly lower after reperfusion in the HOPE group. Therefore, we concluded that end-ischemic HOPE for split-liver transplantation can aid in recovering the graft function and reducing ischemia–reperfusion injury. HOPE, using our originally developed machine perfusion system, is safe and can improve graft function while attenuating liver injury due to preservation.

scholarly journals Full-split liver transplantation. The first experience in Russian Federation

2021 ◽  
Vol 26 (1) ◽  
pp. 66-75
Author(s):  
S. E. Voskanyan ◽  
I. Yu. Kolyshev ◽  
M. V. Shabalin ◽  
A. I. Artemyev ◽  
V. S. Rudakov ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Deceased Donor ◽  
Treatment Method ◽  
Ex Situ ◽  
Biliary Leak ◽  
Team Members ◽  
Split Liver Transplantation ◽  
Split Liver ◽  
Points Of View ◽  
End Stage

Aim. To present the first successful full-split liver transplantation for two adults recipients in Russia.Materials and methods. The first successful full-split liver transplantation for two adults in ex situ way in Russia was made on 26th of September 2014 in the Burnasyan Federal Medical Biophysical Center of FMBA. The deceased donor was inside UNOS, Lee. The GRWR index in both recipients was near 1. The first recipient had been in a waiting list for 1 year, the second for 4 months. Both recipients had got liver cirrhosis in terminal stage.Results. The surgical procedure length was 650 and 660 min. The overall time of cold ischemia was 510 min. We observed a primary function of each graft. ISGLS B and Clavien-Dindo 3A biliary leak complications were observed in both recipients. Both patients were discharged after 33 and 34 days. Overall survival for this moment is 68 months.Conclusion. Full-split liver transplantation for two adults in ex situ way seems to be a complicated procedure both from the technical and organizing points of view. It demanding good mastership and coordination between surgical team members. At the same time, that treatment method has to be spread widely to improve treatment of patients with end-stage cirrhosis results.

A COMPARATIVE EVOLUTION OF EX-SITU AND IN-SITU SPLIT LIVER TRANSPLANTATION - THE PITTSBURGH EXPERIENCE

1999 ◽  
Vol 67 (7) ◽  
pp. S183 ◽  
Author(s):  
J Reyes ◽  
G M Mazareigos ◽  
R Sindhi ◽  
D Gerber ◽  
J Bueno ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ex Situ ◽  
Split Liver Transplantation ◽  
Split Liver ◽  
In Situ Split ◽  
Comparative Evolution

Split liver transplantation: split in-situ or ex-situ?

2000 ◽  
Vol 5 (2) ◽  
pp. 64-68 ◽  
Author(s):  
Xavier Rogiers ◽  
Stefan Topp ◽  
Dieter C. Broering
Keyword(s):  
Liver Transplantation ◽  
Ex Situ ◽  
Split Liver Transplantation ◽  
Split Liver

Hepatic vein reconstruction in ex situ split-liver transplantation

2002 ◽  
Vol 74 (7) ◽  
pp. 1018-1021 ◽  
Author(s):  
Huda M. Noujaim ◽  
Darius F. Mirza ◽  
David A. Mayer ◽  
Jean de Ville de Goyet
Keyword(s):  
Liver Transplantation ◽  
Hepatic Vein ◽  
Ex Situ ◽  
Split Liver Transplantation ◽  
Hepatic Vein Reconstruction ◽  
Split Liver

scholarly journals Combination splitting using both in situ and ex situ techniques in triple split liver transplantation in pigs

1998 ◽  
Vol 11 (6) ◽  
pp. 408-412 ◽  
Author(s):  
Shuji Hayashi ◽  
Takaharu Nagasaka ◽  
Taiki Kojinia ◽  
Yasushi Nainii ◽  
Akio Katayama ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ex Situ ◽  
Split Liver Transplantation ◽  
Split Liver
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