Outcomes of Liver Transplant for Adults With Wilson’s Disease

2020 ◽  
Vol 26 (4) ◽  
pp. 507-516 ◽  
Author(s):  
Alberto Ferrarese ◽  
Maria Cristina Morelli ◽  
Paola Carrai ◽  
Martina Milana ◽  
Mario Angelico ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Wilson’S Disease ◽  
Wilson's Disease

Predictive Factors for Survival in Children Receiving Liver Transplants for Wilson’s Disease: A Cohort Study Using European Liver Transplant Registry Data

2018 ◽  
Vol 24 (9) ◽  
pp. 1186-1198 ◽  
Author(s):  
Eva-Doreen Pfister ◽  
André Karch ◽  
René Adam ◽  
Wojciech G. Polak ◽  
Vincent Karam ◽  
...  
Keyword(s):  
Cohort Study ◽  
Liver Transplant ◽  
Predictive Factors ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Registry Data ◽  
Liver Transplants ◽  
Transplant Registry

scholarly journals Fulminant Wilson’s Disease Managed with Plasmapheresis as a Bridge to Liver Transplant

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Talal Hilal ◽  
R. Scott Morehead
Keyword(s):  
Liver Failure ◽  
Liver Transplant ◽  
Wilson’S Disease ◽  
Acne Vulgaris ◽  
Wilson's Disease ◽  
Serum Copper ◽  
Adjunctive Treatment ◽  
Fulminant Liver Failure ◽  
Parenchymal Liver ◽  
Pathologic Processes

New-onset jaundice can be a manifestation of multiple pathologic processes including hemolysis, parenchymal liver disease, and cholestasis; the differential diagnosis is broad and requires a systematic approach. We report a case of a patient who presented with jaundice after starting minocycline for the treatment of acne vulgaris and rapidly developed fulminant liver failure found to be due to Wilson’s disease. She also manifested severe Coomb’s negative hemolytic anemia and renal failure secondary to hepatorenal syndrome. As a bridge to liver transplant, she was successfully treated with plasmapheresis to decrease serum copper in addition to hemodialysis for acidosis and hyperkalemia. She was able to receive a liver and made a full recovery. The case highlights the use of plasmapheresis as an adjunctive treatment modality in cases of fulminant liver failure due to Wilson’s disease.

A biopsychosocial approach to liver transplant evaluation in two patients with Wilson's disease

2011 ◽  
Vol 16 (3) ◽  
pp. 268-275 ◽  
Author(s):  
Abbe G. Boeka ◽  
Andrea C. Solomon ◽  
Kristine Lokken ◽  
Brendan M. McGuire ◽  
J. Steve Bynon
Keyword(s):  
Liver Transplant ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Biopsychosocial Approach ◽  
Transplant Evaluation

Perspectives of Wilson’s disease treatment

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Agnieszka Antos ◽  
Tomasz Litwin ◽  
Marta Skowrońska ◽  
Iwona Kurkowska-Jastrzębska ◽  
Anna Członkowska
Keyword(s):  
Gene Therapy ◽  
Literature Review ◽  
Liver Transplant ◽  
Digestive Tract ◽  
Wilson’S Disease ◽  
Neurodegenerative Disorder ◽  
Wilson's Disease ◽  
Copper Accumulation ◽  
Disease Treatment ◽  
Secondary Damage

Objectives. Wilson’s disease (WD) is a genetic, neurodegenerative disorder caused by copper metabolism disturbances with subsequent pathological copper accumulation in organs and tissues (mainly liver and brain) with their secondary damage and clinical symptoms related to affected organs. The treatment of the disease is based on medications leading to negative body copper balance, i.e. (1) decreasing absorption of copper from the digestive tract (zinc salts); (2) increasing the copper excretion with urine (chelators: d-penicillamine, trientine, dimercaprol); and (3) liver transplant in specific clinical situations (acute liver failure, liver cirrhosis decompensation despite treatment). The article aims to review the available literature concerning the current research directions in WD treatment. Literature review. During the space of last years, intensive research into the new treatment of WD has started, including: (1) new pharmacological agents (modified thermostable trientine, trientine with delivery system to central nervous system, molybdenum salts, methanobactin, and others); (2) gene therapy; and (3) cells therapy (hepatocytes transplant). We conducted a targeted literature review of PubMed articles written in English, using the following search terms: “Wilson’s disease,” “treatment perspectives,” and “gene therapy.” Reviews, original articles, randomised controlled trials, meta-analyses, book chapters, and abstracts published up to April 2021 were included. Below, we present a narrative synthesis of the extracted data. Conclusions. Currently, chelators, medications decreasing absorption of copper from the digestive tract, and liver transplant are the treatment methods recommended by international societies as a WD treatment. Among the studies on new therapies for WD, the research with tetrathiomolybdate bis-choline is the most advanced and promising. Great hope can be associated with gene therapy.

Mania in a Patient with Wilson’s Disease Awaiting Liver Transplant

2008 ◽  
Vol 20 (4) ◽  
pp. 501-502 ◽  
Author(s):  
Sunny T. Varghese ◽  
Dinesh Narayanan ◽  
Deepa Dinesh
Keyword(s):  
Liver Transplant ◽  
Wilson’S Disease ◽  
Wilson's Disease

scholarly journals When Push Comes to Shove! Emergency ABO-Incompatible Pediatric Living Donor Liver Transplant for Acute Wilson’s Disease

2021 ◽  
Author(s):  
Somashekara Hosaagrahara Ramakrishna ◽  
Mohan Babu Kasala ◽  
Karnan Perumal ◽  
Selvakumar Malleeswaran ◽  
Rajanikanth V. Patcha ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Living Donor ◽  
Wilson’S Disease ◽  
Wilson's Disease ◽  
Donor Liver ◽  
Living Donor Liver Transplant ◽  
Donor Liver Transplant

Massive hepatic haemosiderosis in Wilson's disease

2000 ◽  
Vol 37 (2) ◽  
pp. 187-189 ◽  
Author(s):  
P Luca ◽  
L Demelia ◽  
S Lecca ◽  
R Ambu ◽  
G Faa
Keyword(s):  
Wilson’S Disease ◽  
Wilson's Disease
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