scholarly journals Tissue Inhibitor of Metalloproteinase 3 Deficiency Disrupts the Hepatocyte E‐Cadherin/β‐Catenin Complex and Induces Cell Death in Liver Ischemia/Reperfusion Injury

2019 ◽  
Vol 26 (1) ◽  
pp. 113-126
Author(s):  
Takehiro Fujii ◽  
Sergio Duarte ◽  
Eudora Lee ◽  
Bibo Ke ◽  
Ronald W. Busuttil ◽  
...  
Keyword(s):  
Cell Death ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Liver Ischemia ◽  
Tissue Inhibitor ◽  
E Cadherin

scholarly journals Autophagy and Liver Ischemia-Reperfusion Injury

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Raffaele Cursio ◽  
Pascal Colosetti ◽  
Jean Gugenheim
Keyword(s):  
Cell Death ◽  
Hemorrhagic Shock ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Current Knowledge ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Main Mode ◽  
Patient Morbidity ◽  
Diseased Liver

Liver ischemia-reperfusion (I-R) injury occurs during liver resection, liver transplantation, and hemorrhagic shock. The main mode of liver cell death after warm and/or cold liver I-R is necrosis, but other modes of cell death, as apoptosis and autophagy, are also involved. Autophagy is an intracellular self-digesting pathway responsible for removal of long-lived proteins, damaged organelles, and malformed proteins during biosynthesis by lysosomes. Autophagy is found in normal and diseased liver. Although depending on the type of ischemia, warm and/or cold, the dynamic process of liver I-R results mainly in adenosine triphosphate depletion and in production of reactive oxygen species (ROS), leads to both, a local ischemic insult and an acute inflammatory-mediated reperfusion injury, and results finally in cell death. This process can induce liver dysfunction and can increase patient morbidity and mortality after liver surgery and hemorrhagic shock. Whether autophagy protects from or promotes liver injury following warm and/or cold I-R remains to be elucidated. The present review aims to summarize the current knowledge in liver I-R injury focusing on both the beneficial and the detrimental effects of liver autophagy following warm and/or cold liver I-R.

scholarly journals Imbalance Between Tissue Inhibitor of Metalloproteinase-4 and Matrix Metalloproteinases During Acute Myoctardial Ischemia-Reperfusion Injury

Circulation ◽  
2003 ◽  
Vol 107 (19) ◽  
pp. 2487-2492 ◽  
Author(s):  
Costas J. Schulze ◽  
Wenjie Wang ◽  
Wilma L. Suarez-Pinzon ◽  
Jolanta Sawicka ◽  
Grzegorz Sawicki ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor

Ischemic Preconditioning Prevents Apoptotic Cell Death and Necrosis in Early and Intermediate Phases of Liver Ischemia-Reperfusion Injury in Rats

2006 ◽  
Vol 19 (4) ◽  
pp. 229-236 ◽  
Author(s):  
Claudemiro Quireze ◽  
Edna Frasson de Souza Montero ◽  
Regina Maria Cubero Leitão ◽  
Yara Juliano ◽  
Djalma José Fagundes ◽  
...  
Keyword(s):  
Cell Death ◽  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Apoptotic Cell ◽  
Ischemia Reperfusion ◽  
Apoptotic Cell Death ◽  
Liver Ischemia ◽  
Intermediate Phases

Glutathione protects mitochondrion and alleviates liver ischemia-reperfusion injury in rats

2015 ◽  
Vol 36 (12) ◽  
pp. 1300
Author(s):  
Lin-lin CAI ◽  
Hai-long FU ◽  
Qing-qing ZHANG ◽  
Yong-hua LI ◽  
Qiu-feng ZHU ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia

Arrb1 Ameliorates Liver Ischemia/Reperfusion Injury Via Interacting with TRAF6 in Hepatocytes

2019 ◽  
Author(s):  
Xiaoliang Xu ◽  
Zechuan Zhang ◽  
Yijun Lu ◽  
Qikai Sun ◽  
Yang Liu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia

Beneficial effects of natural compounds on experimental liver ischemia-reperfusion injury

2021 ◽  
Author(s):  
Camila Dossi ◽  
Romina Vargas ◽  
Rodrigo Valenzuela ◽  
Luis Videla
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Natural Compounds ◽  
Liver Ischemia ◽  
Hepatic Surgery ◽  
Beneficial Effects ◽  
Underlying Mechanisms ◽  
Experimental Liver

Liver ischemia-reperfusion injury (IRI) is a phenomenon inherent to hepatic surgery that severely compromises the organ functionality, whose underlying mechanisms involve cellular and molecular interrelated processes leading to the development...

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