scholarly journals Phosphatase and tensin homolog-β-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury

2017 ◽  
Vol 23 (6) ◽  
pp. 813-825 ◽  
Author(s):  
Qiang Zhu ◽  
Changyong Li ◽  
Kunpeng Wang ◽  
Shi Yue ◽  
Longfeng Jiang ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Reperfusion Injury ◽  
Mouse Liver ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Phosphatase And Tensin Homolog ◽  
Tensin Homolog

scholarly journals ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

Hepatology ◽  
2013 ◽  
Vol 58 (1) ◽  
pp. 351-362 ◽  
Author(s):  
Naoko Kamo ◽  
Bibo Ke ◽  
Amir A. Ghaffari ◽  
Xiu-da Shen ◽  
Ronald W. Busuttil ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Caspase 1

scholarly journals Netrin-1 reduces lung ischemia-reperfusion injury by increasing the proportion of regulatory T cells

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092641
Author(s):  
Zhili Chen ◽  
Yuxi Chen ◽  
Jue Zhou ◽  
Yong Li ◽  
Changyao Gong ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
T Cells ◽  
Regulatory T Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Axonal Guidance ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Treg Depletion

Objective Inflammation is the primary mechanism of lung ischemia-reperfusion injury (LIRI) and neurologic factors can regulate inflammatory immune responses. Netrin-1 is an axonal guidance molecule, but whether Netrin-1 plays a role in LIRI remains unclear. Methods A mouse model of LIRI was established. Immunohistochemistry was used to detect expression of Netrin-1 and to enumerate macrophages and T cells in lung tissue. The proportion of regulatory T cells (Tregs) was assessed by flow cytometry. Levels of apoptosis were assessed by terminal deoxynucleotidyl transferase dUTP nick end staining. Results Numbers of macrophages and T cells in the lung tissues of mice with LIRI were elevated, while expression of netrin-1 was significantly decreased. Flow cytometry showed that the proportion of Tregs in mice with LIRI was significantly decreased. The proportion of Tregs among lymphocytes was positively correlated with netrin-1 expression. In vitro experiments showed that netrin-1 promoted an increase in Treg proportion through the A2b receptor. Animal experiments showed that netrin-1 could inhibit apoptosis and reduce T cell and macrophage infiltration by increasing the proportion of Tregs, ultimately reducing LIRI. Treg depletion using an anti-CD25 monoclonal antibody blocked the effects of netrin-1. Conclusion Netrin-1 reduced LIRI by increasing the proportion of Tregs.

Regulatory T cells contribute to rosuvastatin-induced cardioprotection against ischemia-reperfusion injury

2013 ◽  
Vol 24 (4) ◽  
pp. 334-341 ◽  
Author(s):  
Dan Ke ◽  
Jun Fang ◽  
Lin Fan ◽  
Zhaoyang Chen ◽  
Lianglong Chen
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion
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