Risk analysis of ischemic-type biliary lesions after liver transplant using octogenarian donors

2016 ◽  
Vol 22 (10) ◽  
pp. 1443-1444
Author(s):  
Mikel Gastaca ◽  
Mikel Guerra ◽  
Patricia Ruiz ◽  
Alberto Ventoso ◽  
Andrés Valdivieso ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Liver Transplant ◽  
Ischemic Type Biliary Lesions

scholarly journals Risk analysis of ischemic-type biliary lesions after liver transplant using octogenarian donors

2016 ◽  
Vol 22 (5) ◽  
pp. 588-598 ◽  
Author(s):  
Davide Ghinolfi ◽  
Paolo De Simone ◽  
Quirino Lai ◽  
Daniele Pezzati ◽  
Laura Coletti ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Liver Transplant ◽  
Ischemic Type Biliary Lesions

scholarly journals Risk analysis of ischemic-type biliary lesions after liver transplant using octogenarian donors

2016 ◽  
Vol 22 (9) ◽  
pp. 1301-1302 ◽  
Author(s):  
Michel Rayar ◽  
Giovanni Battista Levi Sandri ◽  
Caterina Cusumano ◽  
Pauline Houssel-Debry ◽  
Christophe Camus ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Liver Transplant ◽  
Ischemic Type Biliary Lesions

scholarly journals Mortality on the UNOS Waitlist for Patients with Autoimmune Liver Disease

2020 ◽  
Vol 9 (2) ◽  
pp. 319
Author(s):  
Jaspreet S. Suri ◽  
Christopher J. Danford ◽  
Vilas Patwardhan ◽  
Alan Bonder
Keyword(s):  
Liver Disease ◽  
Risk Analysis ◽  
Liver Transplant ◽  
Autoimmune Hepatitis ◽  
Competing Risk ◽  
Clinical Deterioration ◽  
Primary Biliary Cholangitis ◽  
Competing Risk Analysis ◽  
Subdistribution Hazard ◽  
Similar Risk

Background: Outcomes on the liver transplant waitlist can vary by etiology. Our aim is to investigate differences in waitlist mortality of autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) using the United Network for Organ Sharing (UNOS) database. Methods: We identified patients who were listed for liver transplantation from 1987 to 2016 with a primary diagnosis of AIH, PBC, or PSC. We excluded patients with overlap syndromes, acute hepatic necrosis, missing data, and those who were children. The primary outcome was death or removal from the waitlist due to clinical deterioration. We compared waitlist survival using competing risk analysis. Results: Between 1987 and 2016, there were 7412 patients listed for liver transplant due to AIH, 8119 for PBC, and 10,901 for PSC. Patients with AIH were younger, more likely to be diabetic, and had higher listing model for end-stage liver disease (MELD) scores compared to PBC and PSC patients. Patients with PBC and AIH were more likely to be removed from the waitlist due to death or clinical deterioration. On competing risk analysis, AIH patients had a similar risk of being removed from the waitlist compared to those with PBC (subdistribution hazard ratio (SHR) 0.94, 95% CI 0.85–1.03) and higher risk of removal compared to those with PSC (SHR 0.8, 95% CI 0.72 to 0.89). Conclusion: Autoimmune hepatitis carries a similar risk of waitlist removal to PBC and a higher risk than PSC. The etiology of this disparity is not entirely clear and deserves further investigation.

New Onset Diabetes and Impaired Fasting Glucose After Liver Transplant: Risk Analysis and the Impact of Tacrolimus Dose

2014 ◽  
Vol 12 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Kamran Bagheri Lankarani ◽  
◽  
Ahad Eshraghian ◽  
Saman Nikeghbalian ◽  
Parisa Janghorban ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Liver Transplant ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Onset Diabetes ◽  
The Impact ◽  
Tacrolimus Dose ◽  
New Onset

scholarly journals A model including sarcopenia surpasses the MELD score in predicting waiting list mortality in cirrhotic liver transplant candidates: A competing risk analysis in a national cohort

2018 ◽  
Vol 68 (4) ◽  
pp. 707-714 ◽  
Author(s):  
Jeroen Laurens Ad van Vugt ◽  
Louise Johanna Maria Alferink ◽  
Stefan Buettner ◽  
Marcia Patricia Gaspersz ◽  
Daphne Bot ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Liver Transplant ◽  
Meld Score ◽  
Cirrhotic Liver ◽  
Waiting List ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
National Cohort ◽  
Transplant Candidates

scholarly journals Waitlist Mortality and Posttransplant Outcomes in African Americans with Autoimmune Liver Diseases

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
John Paul Nsubuga ◽  
Daniela Goyes ◽  
Hirsh D. Trivedi ◽  
Esli Medina-Morales ◽  
Vilas Patwardhan ◽  
...  
Keyword(s):  
African Americans ◽  
Risk Analysis ◽  
Liver Transplant ◽  
Graft Survival ◽  
Liver Diseases ◽  
Cox Regression ◽  
Survival Rates ◽  
Competing Risk ◽  
Competing Risk Analysis ◽  
Autoimmune Liver Diseases

Background. Liver transplantation is indicated in end-stage liver disease due to autoimmune diseases. The liver allocation system can be affected by disparities such as decreased liver transplant referrals for racial minorities, especially African Americans that negatively impact the pre- and posttransplant outcomes. Aim. To determine differences in waitlist survival and posttransplant graft survival rates between African American and Caucasian patients with autoimmune liver diseases. Study. The United Network for Organ Sharing database was used to identify all patients with autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis who underwent liver transplant from 1988 to 2019. We compared waitlist survival and posttransplant graft survival between Caucasians and African Americans using Kaplan–Meier curves and Cox regression models. We also evaluated the cumulative incidence of death or delisting for deterioration and posttransplant incidence of death and retransplantation using competing risk analysis. Results. African Americans were more likely to be removed from the waitlist for death or clinical deterioration (subdistribution hazard ratio (SHR) 1.26, 95% CI 1–1.58, P = 0.046 ) using competing risk analysis. On multivariate Cox regression analysis, there was no difference in posttransplant graft survival among the two groups (hazard ratio (HR) 1.10, 95% CI 0.98–1.23, P = 0.081 ). Conclusions. Despite the current efforts to reduce racial disparities, we found that African Americans are more likely to die on the waitlist for liver transplant and are less likely to be transplanted, with no differences in graft survival rates. The persistence of healthcare disparities continues to negatively impact African Americans.

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