scholarly journals Protective role of normothermic machine perfusion during reduced-size liver transplantation in pigs

2016 ◽  
Vol 22 (7) ◽  
pp. 968-978 ◽  
Author(s):  
Zhi-Bin Zhang ◽  
Wei Gao ◽  
Yuan Shi ◽  
Lei Liu ◽  
Ning Ma ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Protective Role ◽  
Machine Perfusion ◽  
Normothermic Machine Perfusion

The role of normothermic machine perfusion in liver transplantation

2020 ◽  
Vol 82 ◽  
pp. 52-60 ◽  
Author(s):  
Paulo N. Martins ◽  
Julianna E. Buchwald ◽  
Hynek Mergental ◽  
Luciano Vargas ◽  
Cristiano Quintini
Keyword(s):  
Liver Transplantation ◽  
Machine Perfusion ◽  
Normothermic Machine Perfusion

Recent advances in liver transplantation

2021 ◽  
pp. flgastro-2020-101425
Author(s):  
N Thomas Burke ◽  
James B Maurice ◽  
David Nasralla ◽  
Jonathan Potts ◽  
Rachel Westbrook
Keyword(s):  
Liver Transplantation ◽  
Survival Rates ◽  
Machine Perfusion ◽  
Allocation System ◽  
Life Saving ◽  
Opt Out ◽  
Normothermic Machine Perfusion ◽  
Marginal Grafts ◽  
Legislative Changes ◽  
The Uk

Liver transplant is a life-saving treatment with 1-year and 5-year survival rates of 90% and 70%, respectively. However, organ demand continues to exceed supply, such that many patients will die waiting for an available organ. This article reviews for the general gastroenterologist the latest developments in the field to reduce waiting list mortality and maximise utilisation of available organs. The main areas covered include legislative changes in organ donation and the new ‘opt-out’ systems being rolled out in the UK, normothermic machine perfusion to optimise marginal grafts, a new national allocation system to maximise benefit from each organ and developments in patient ‘prehabilitation’ before listing. Current areas of research interest, such as immunosuppression withdrawal, are also summarised.

scholarly journals Machine Perfusion: Cold versus Warm, versus Neither. Update on Clinical Trials

2020 ◽  
Vol 40 (03) ◽  
pp. 264-281 ◽  
Author(s):  
E. Bonaccorsi-Riani ◽  
I.M.A. Brüggenwirth ◽  
J.E. Buchwald ◽  
S. Iesari ◽  
P.N. Martins
Keyword(s):  
Liver Transplantation ◽  
Clinical Trials ◽  
Ex Situ ◽  
Machine Perfusion ◽  
Correct Trial ◽  
Gold Standard Method ◽  
Liver Preservation ◽  
Mature Phase ◽  
Normothermic Machine Perfusion ◽  
Human Livers

AbstractMachine perfusion (MP) preservation is potentially one of the most significant improvements in the field of liver transplantation in the last 20 years, and it has been considered a promising strategy for improved preservation and ex situ evaluation of extended criteria donor (ECD) organs. However, MP preservation adds significant cost and logistical considerations to liver transplantation. MP protocols are mainly classified according to the perfusion temperature with hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) being the two categories most studied so far. After extensive preclinical work, MP entered the clinical setting, and there are now several studies that demonstrated feasibility and safety. However, because of the limited quality of clinical trials, there is no compelling evidence of superiority in preservation quality, and liver MP is still considered experimental in most countries. MP preservation is moving to a more mature phase, where ongoing and future studies will bring new evidence in order to confirm their superiority in terms of clinical outcomes, organ utilization, and cost-effectiveness. Here, we present an overview of all preclinical MP studies using discarded human livers and liver MP clinical trials, and discuss their results. We describe the different perfusion protocols, pitfalls in MP study design, and provide future perspectives. Recent trials in liver MP have revealed unique challenges beyond those seen in most clinical studies. Randomized trials, correct trial design, and interpretation of data are essential to generate the data necessary to prove if MP will be the new gold standard method of liver preservation.

Protective Role of the Portocaval Shunt in Liver Transplantation

2020 ◽  
Vol 52 (5) ◽  
pp. 1455-1458
Author(s):  
Laura Tortolero ◽  
Javier Nuño ◽  
Adolfo Buenadicha ◽  
Luis Gajate ◽  
Ana Serrano ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Protective Role ◽  
Portocaval Shunt

Protective Role of the L-Arginine-Nitric Oxide Synthase Pathway on Preservation Injury after Rat Liver Transplantation

2001 ◽  
Vol 25 (3) ◽  
pp. 142-147 ◽  
Author(s):  
David A. Geller ◽  
Stanley H. Chia ◽  
Yoshihito Takahashi ◽  
Gautam P. Yagnik ◽  
George Tsoulfas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Transplantation ◽  
Nitric Oxide Synthase ◽  
Rat Liver ◽  
Protective Role ◽  
Rat Liver Transplantation ◽  
Preservation Injury ◽  
Oxide Synthase

scholarly journals First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion

2015 ◽  
Vol 22 (1) ◽  
pp. 120-124 ◽  
Author(s):  
Thamara Perera ◽  
Hynek Mergental ◽  
Barney Stephenson ◽  
Garrett R. Roll ◽  
Hentie Cilliers ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Human Liver ◽  
Machine Perfusion ◽  
Normothermic Machine Perfusion

scholarly journals Role of hypothermic machine perfusion in liver transplantation

2014 ◽  
Vol 28 (6) ◽  
pp. 677-689 ◽  
Author(s):  
Andrea Schlegel ◽  
Philipp Dutkowski
Keyword(s):  
Liver Transplantation ◽  
Machine Perfusion ◽  
Hypothermic Machine Perfusion

Role of Vasodilation during Normothermic Machine Perfusion of DCD Porcine Livers

2014 ◽  
Vol 37 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Ahmed Nassar ◽  
Qiang Liu ◽  
Kevin Farias ◽  
Giuseppe D'Amico ◽  
Laura Buccini ◽  
...  
Keyword(s):  
Machine Perfusion ◽  
Normothermic Machine Perfusion
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